Direkte orale Antikoagulanzien – wichtige Unterschiede und Kerndaten

Abstract

Direct oral anticoagulants (DOAC) are alternatives to vitamin K antagonists for prophylaxis of stroke in non-valvular atrial fibrillation and prophylaxis and therapy of venous thromboembolism. Currently there is a choice between the four DOACs Apixaban, Dabigatran, Edoxaban and Rivaroxaban. Strategies for differential therapy regarding indications, dosing, costs, drug interactions and cautions concerning impaired renal function are discussed briefly.

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