Laryngorhinootologie 2016; 95(S 01): S155-S191
DOI: 10.1055/s-0041-108946
Originalarbeit
© Georg Thieme Verlag KG Stuttgart · New York

Evidenz- und Evidenzlücken der Tinnitustherapie

Evidence and Lack of Evidence in the Treatment of Tinnitus
G. Hesse
Further Information

Publication History

Publication Date:
29 April 2016 (online)

Zusammenfassung

Für die Behandlung von Ohrgeräuschen werden eine schier unübersichtliche Vielzahl von Verfahren erprobt und v. a. verkauft, leider nicht immer sachgerecht und evidenzbasiert untersucht. Eine kausale, den Tinnitus abschaltende Therapie gibt es nach wie vor nicht, ja eigentlich kann es sie nicht geben, hat man die verschiedenen Entstehungsmechanismen verstanden. Dennoch oder deshalb kehren im Verlauf der letzten Jahrzehnte wellen- und modeartig medizinische Interventionen wieder, die praktisch nie den Nachweis stabiler und belastbarer Behandlungserfolge erbringen können. In diesem Referat werden praktisch alle gängigen Therapieverfahren besprochen, gewürdigt und diskutiert und bezüglich vorliegender oder eben nicht bestehender Evidenz bewertet. Dabei sollte Evidenz neben der externen Evidenz durch Studien auch die interne Evidenz, d. h. die Erfahrung des Arztes und die Bedürfnisse des Patienten mit einbeziehen.

Während für praktisch alle direkten Verfahren, die entweder die Kochlea oder bestimmte Hirnregionen wie insbesondere den auditorischen Kortex stimulieren oder modulieren wollen, keine Evidenz besteht oder erreicht wird, so gibt es Therapieverfahren, die sich in der klinischen Praxis bewährt haben und die zumindest einen gewissen Evidenzgrad und v. a. auch nachweisbare Effektstärken generieren. Dazu gehören besonders Habituationstherapien und psychotherapeutische Verfahren, besonders wenn sie mit konkreten Maßnahmen zur Verbesserung der Hörwahrnehmung (Hörgeräte, CI, Hörtherapien) verknüpft werden.

Abstract

A broad variety of therapeutic regimen is proposed, introduced and sold against tinnitus, but most of these approaches lack scientific validation and evidence. Up to date a causal, tinnitus eliminating therapy is not available. Most probably this will not be possible at all, as the mechanism of tinnitus generation are multiple and include peripheral as well as central or cortical reactions. Like in fashion and design however, therapeutic medical interventions against tinnitus come in waves again and again over the last decades, without being able to prove lasting and scientifically evident effects.

This review presents, discusses and assesses almost all available therapies regarding their evidence. Evidence should include besides external evidence through publications and available data also internal evidence, e.g. including experience of the therapist and needs of the patients.

Almost all interventions that try to influence the inner ear or the auditory cortex either pharmaceutically or by direct stimulation or modulation do not reach evidence. However, there are procedures that have proven to be effective and show at least certain degrees of evidence with proven strength of effect. These are habituation therapies and psychotherapeutic interventions like cognitive behavioural therapy, especially when they are combined with concrete measures to improve auditory perception like hearing-aids, cochlear implants or hearing-therapy.

 
  • Literatur

  • 1 Pilgramm M, Kirchhoff D, Pfeil T et al. Wieviele Personen leiden in der Bundesrepublik Deutschland im Jahr 1998 am Symptom Tinnitus? Eine epidemiologische Untersuchung. In, 70 Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirugie. Aachen 1999
  • 2 Hesse G. Innenohrschwerhörigkeit. Stuttgart: Thieme; 2015
  • 3 Xu X, Bu X, Zhou L et al. An epidemiologic study of tinnitus in a population in jiangsu province, china. Journal of the American Academy of Audiology 2011; 22: 578-585
  • 4 Maes IH, Cima RF, Vlaeyen JW et al. Tinnitus: A Cost Study. Ear and hearing 2013; DOI: 10.1097/AUD.0b013e31827d113a.
  • 5 Lenarz T. Diagnostik und Therapie des Tinnitus. Laryngology Rhinology Otology 1998; 77: 54-60
  • 6 Hesse G. Newest therapeutic approaches for chronic tinnitus. HNO 2015; 63: 283-290
  • 7 Hesse G, Rienhoff NK, Laubert A. Ergebnisse stationärer Therapie bei Patienten mit chronisch komplexem Tinnitus. Laryngo-Rhino-Otology 2001; 80: 503-508
  • 8 Norena AJ. Revisiting the Cochlear and Central Mechanisms of Tinnitus and Therapeutic Approaches. Audiology & neuro-otology 2015; 20 (Suppl. 01) 53-59
  • 9 Hesse G, Schaaf H, Laubert A. Specific Findings in Distortion Product Otoacoustic Emissions and Growth Functions with Chronic Tinnitus. International Tinnitus Journal 2005; 11: 6-13
  • 10 Riga M, Papadas T, Werner JA et al. A Clinical Study of the Efferent Auditory System in Patients With Normal Hearing Who Have Acute Tinnitus. Otology & Neurotology 2007; 28: 185-190
  • 11 Engineer N, Rosellini W, Tyler R. Willingness to Accept and Pay for Implantable Tinnitus Treatments: A Survey. Neuromodulation: journal of the International Neuromodulation Society 2013; 16: 154-162
  • 12 Tyler R. Patient preferences and willingness to pay for tinnitus treatments. Journal of the American Academy of Audiology 2012; 23: 115-125
  • 13 Greimel KV. Alles nur Einbildung? Über die Wirkung von „Placebos“. In: Biesinger E, Iro H. Hrsg HNO Praxis heute. Heidelberg: Springer Verlag; 2005: 163-171
  • 14 Kröner-Herwig B, Jäger B, Goebel G. Tinnitus: Kognitiv-verhaltenstherapeutisches Behandlungsmanual. Weinheim und Basel: Beltz; 2010
  • 15 Delb W, D’Amelio R, Archonti C, Schonecke O. Tinnitus – Ein Manual zur Tinnitus-Retrainingtherapie. Göttingen: Hogrefe; 2002
  • 16 Martinez Devesa P, Waddell A, Perera R et al. Cognitive behavioural therapy for tinnitus. Cochrane Database Syst Rev 2010; 24: CD005233 PMID: 20824844
  • 17 Schaaf H, Gieler U. TRT and psychotherapy in the treatment of tinnitus. HNO 2010; 58: 999-1003
  • 18 Schaaf HSB. Not verschafft sich Gehör. HNO-Nachrichten 2002; 8: 16-19
  • 19 Franz M, Ballo H, Heckrath C et al. Tinnitus als soziale Infektion. Tinnitus als Indikator eines dekompensierten Gruppenprozesses innerhalb einer Organisation. Psychotherapeut 2005; 50: 318-327
  • 20 Tillmann M. Der gesellschaftliche Prozess der Globalisierung und die Notwendigkeit von Intimität. Ein Versuch zum individuellen und kulturellen Verständnis der psychodynamischen Bedeutung des Tinnitus aurium. Psychosozial 2007; 107: 109-130
  • 21 Hesse G. Retraining und Tinnitustherapie. Stuttgart, New York: Thieme; 2000
  • 22 Coyle PK. Evidence-based medicine and clinical trials. Neurology 2007; 68: S3-S7
  • 23 Goebel G, Kahl M, Arnold W et al. 15-year prospective follow-up study of behavioral therapy in a large sample of inpatients with chronic tinnitus. Acta oto-laryngologica 2006; 126: 70-79
  • 24 Goebel G, Hiller W. TinnitusFragebogen (TF). Ein Instrument zur Erfassung von Belastung und Schweregrad bei Tinnitus (siehe Anlage tinnitus Fragebogen). Göttingen. Bern, Toronto, Seattle: Hogrefe Verlag für Psychologie; 1998
  • 25 Weßling H. Theorie der klinischen Evidenz. Versuch einer Kritik der Evidenzbasierten Medizin. Zürich: Lit.-Verlag; 2012
  • 26 Turner EH, Matthews AM, Linardatos E et al. Selective publication of antidepressant trials and its influence on apparent efficacy. The New England journal of medicine 2008; 358: 252-260
  • 27 Yank V, Rennie D, Bero LA. Financial ties and concordance between results and conclusions in meta-analyses: retrospective cohort study. Bmj 2007; 335: 1202-1205
  • 28 Kern RS, Zarate R, Glynn SM et al. A demonstration project involving peers as providers of evidence-based, supported employment services. Psychiatric rehabilitation journal 2013; 36: 99-107
  • 29 El Dib RP, Atallah AN, Andriolo RB. Mapping the Cochrane evidence for decision making in health care. Journal of evaluation in clinical practice 2007; 13: 689-692
  • 30 AWMF. Leitlinie Hörsturz. Leitlinien der Dt Ges f Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie. 2014 Leitlinie 017/010 1-10
  • 31 AWMF. Leitlinie Tinnitus. Leitlinien der Dt Ges f Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie. 2015 Leitlinie 017/064 1-16
  • 32 Schaaf H, Eisenberg C, Hesse G. Tinnitus und das Leiden am Tinnitus. Psychotherapeut 2010; DOI: im Druck
  • 33 Goebel G, Fichter M. Psychiatrische Komorbidität bei Tinnitus. In: Biesinger E, Iro H. (Hrsg.) HNO Praxis heute. Heidelberg: Springer-Verlag; 2005: 137-150
  • 34 Geven LI, Koppl C, de Kleine E et al. Plasticity in Tinnitus Patients: a Role for the Efferent Auditory System?. Otology & neurotology 35: 796-802
  • 35 Pichora-Fuller MK, Santaguida P, Hammill A et al. Evaluation and Treatment of Tinnitus: Comparative Effectiveness. In Comparative Effectiveness Reviews. No 122. Rockville (MD) 2013
  • 36 Hoare D, Kowalkowski V, Kang S et al. Systematic review and meta-analyses of randomized controlled trials examining tinnitus management. The Laryngoscope 2011; 121: 1555-1564
  • 37 Fioretti A, Eibenstein A, Fusetti M. New Trends in Tinnitus Management. The Open Neurology Journal 2011; 5: 12-17
  • 38 Landgrebe M, Azevedo A, Baguley D et al. Methodological aspects of clinical trials in tinnitus: A prosposal for an international standard. Journal of psychosomatic research 2012; 73: 112-121
  • 39 Tunkel DE, Bauer CA, Sun GH et al. Clinical practice guideline: tinnitus. Otolaryngology–head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2014; 151: S1-S40
  • 40 Tunkel DE, Bauer CA, Sun GH et al. Clinical practice guideline: tinnitus executive summary. Otolaryngology–head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2014; 151: 533-541
  • 41 Zenner HP. Current treatment of sensorineural hearing loss and chronic tinnitus. HNO 2015; 63: 394-395
  • 42 Rote Liste. Arzneimittelinforamtion für Deutschland. Frankfurt/Main: Rote Liste; 2015
  • 43 Hesse G. Neueste Behandlungsansätze bei chronischem Tinnitus. HNO 2015; 63
  • 44 Topak M, Sahin-Yilmaz A, Ozdoganoglu T et al. Intratympanic methylprednisolone injections for subjective tinnitus. J Laryngol Otol 2009; 29: 1-5
  • 45 An YH, Yu KK, Kwak MY et al. Prognostic factors for the outcomes of intratympanic dexamethasone in the treatment of acute subjective tinnitus. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2014; 35: 1330-1337
  • 46 Suckfuell M, Lisowska G, Domka W et al. Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss: A Double-Blind, Randomized, Placebo-Controlled Phase II Study. Otology & neurotology 35: 1317-1326
  • 47 Muehlmeier G, Biesinger E, Maier H. Safety of Intratympanic Injection of AM-101 in Patients with Acute Inner Ear Tinnitus. Audiology & neuro-otology 2011; 16: 388-397
  • 48 van de Heyning P, Muehlmeier G, Cox T et al. Efficacy and Safety of AM-101 in the Treatment of Acute Inner Ear Tinnitus-A Double-Blind, Randomized, Placebo-Controlled Phase II Study. Otology & neurotology 35: 589-597
  • 49 Staecker H, Maxwell KS, Morris JR et al. Selecting Appropriate Dose Regimens for AM-101 in the Intratympanic Treatment of Acute Inner Ear Tinnitus. Audiology & neuro-otology 2015; 20: 172-182
  • 50 Shim H, Jun Song S, Choi A et al. Comparison of various treatment modalities for acute tinnitus. The Laryngoscope 2011; 121: 2619-2625
  • 51 de Azevedo A, Langguth B, de Oliveira P et al. Tinnitus Treatment With Piribedil Guided by Electrocochleography and Acoustic Otoemissions. Otology & neurotology: official publication of the American Otological Society. American Neurotology Society [and] European Academy of Otology and Neurotology 2009; 30: 676-680
  • 52 Mazurek B, Haupt H, Szczepek A et al. Evaluation of vardenafil for the treatment of subjective tinnitus: a controlled pilot study. J Negat Results Biomed 2009; 8: 3
  • 53 Hoekstra C, Rynia S, van Zanten G et al. Anticonvulsants for tinnitus. Cochrane Database Syst Rev 2011; 6: CD007960
  • 54 Suckfull M, Althaus M, Ellers-Lenz B et al. A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of neramexane in patients with moderate to severe subjective tinnitus. BMC ear, nose, and throat disorders 2011; 11: 1
  • 55 Hurtuk A, Dome C, Holloman C et al. Melatonin: can it stop the ringing?. Ann Otol Rhinol Laryngol 2011; 120: 433-440
  • 56 Reiter R, Tan D, Korkmaz A et al. Drug-mediated ototoxicity and tinnitus: alleviation with melatonin. J Physiol Pharmacol 2011; 62: 151-157
  • 57 Miroddi M, Bruno R, Galletti F et al. Clinical pharmacology of melatonin in the treatment of tinnitus: a review. European journal of clinical pharmacology 2015; DOI: 10.1007/s00228-015-1805-3.
  • 58 Roberts C, Inamdar A, Koch A et al. A Randomized, Controlled Study Comparing the Effects of Vestipitant or Vestipitant and Paroxetine Combination in Subjects With Tinnitus. Otology & Neurotology 2011; 32: 721-727
  • 59 Taslimi S, Vahidi H, Pourvaziri A et al. Ondansetron in patients with tinnitus: randomized double-blind placebo-controlled study. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2012; DOI: 10.1007/s00405-012-2179-0.
  • 60 Choi SJ, Lee JB, Lim HJ et al. Intratympanic dexamethasone injection for refractory tinnitus: Prospective placebo-controlled study. The Laryngoscope 2013; 123: 2817-2822
  • 61 Smith P, Zheng Y, Darlington C. Revisiting baclofen for the treatment of severe chronic tinnitus. Frontiers in neurology 2012; 3: 00
  • 62 Vanneste S, Figueiredo R, Ridder D. Treatment of tinnitus with cyclobenzaprine: an open-label study. Int J Clin Pharmacol Ther 2012; 50: 338-344
  • 63 Coelho C, Figueiredo R, Frank E et al. Reduction of Tinnitus Severity by the Centrally Acting Muscle Relaxant Cyclobenzaprine: An Open-Label Pilot Study. Audiology & neuro-otology 2012; 17: 179-188
  • 64 Meeus O, De Ridder D, Van de Heyning P. Administration of the Combination Clonazepam-Deanxit as Treatment for Tinnitus. Otology & Neurotology 2011; 32: 701-709
  • 65 Han S, Nam E, Won J et al. Clonazepam Quiets tinnitus: a randomised crossover study with Ginkgo Biloba. Journal of neurology, neurosurgery, and psychiatry 2012; 23 Epub ahead of print
  • 66 Baldo P, Doree C, Molin P et al. Antidepressants for patients with tinnitus. Cochrane Darabase Syst Rev 2012; 00: 00
  • 67 Roland P, Nergard C. Ginkgo biloba – effect, adverse events and drug interaction. Tidsskr Nor Laegeforen 2012; 132: 956-959
  • 68 Hilton MP, Zimmermann EF, Hunt WT. Ginkgo biloba for tinnitus. The Cochrane database of systematic reviews 2013; 3: CD003852
  • 69 Drew S, Davies E. Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial. Bmj 2001; 322: 73-79
  • 70 Hesse G, Schaaf H. Ginkgo biloba: Unwirksam gegen Tinnitus?. HNO 2001; 6: 434-436
  • 71 von Boetticher A. Ginkgo biloba extract in the treatment of tinnitus: a systematic review. Neuropsychiatric disease and treatment 2011; 7: 441-447
  • 72 Witsell DL, Hannley MT, Stinnet S et al. Treatment of Tinnitus With Gabapentin: A Pilot Study. Otology & Neurotology 2006; 28: 11-15
  • 73 Coelho C, Witt SA, Ji H et al. Zinc to Treat Tinnitus in the Elderly: A Randomized Placebo Controlled Crossover Trial. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2013; 34: 1146-1154
  • 74 Sönmez O, Kulahli I, Vural A et al. The evaluation of ozone and betahistine in the treatment of tinnitus. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2013; 270: 1999-2006
  • 75 Espinosa-Sanchez JM, Heitzmann-Hernandez T, Lopez-Escamez JA. Pharmacotherapy for tinnitus: much ado about nothing. Revista de neurologia 2014; 59: 164-174
  • 76 Shi Y, Robb MJ, Michaelides EM. Medical management of tinnitus: role of the physician. Journal of the American Academy of Audiology 2014; 25: 23-28
  • 77 Mielczarek M, Olszewski J. Direct current stimulation of the ear in tinnitus treatment: a double-blind placebo-controlled study. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2014; 271: 1815-1822
  • 78 Perez R, Shaul C, Vardi M et al. Multiple electrostimulation treatments to the promontory for tinnitus. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2015; 36: 366-372
  • 79 Brusis T, Loennecken I. Die Behandlung von Ohrgeräuschen mit der Iontophorese-Lokalanästhesie. Laryngo-Rhinol-Otol 1985; 64: 355-358
  • 80 Wilden I, Karthein R. Import of radiation phenomena of electrons and therapeutic low-level laser in regard to the mitochondrial energy transfer. J Clin Laser Med Surg 1998; 16: 159-165
  • 81 PartheniadisStumpf M, Maurer J, Mann W. Softlasertherapie in Kombination mit Tebonin i. v. bei Tinnitus. Laryngo Rhino Otol 1993; 72: 28-31
  • 82 Walger M, v.Wedel H, Calero L et al. Ergebnisse einer Studie zur Effektivität einer Low-PowerLaser und GingkoTherapie auf den chronischen Tinnitus. HNOInformationen 1993; 3: 35-36
  • 83 Wedel vH, Calero L, Walger M et al. Soft-laser/Ginkgo therapy in chronic tinnitus: A. placebo-controlled study. Adv Otorhinolaryngol 1995; 49: 105-108
  • 84 Mirz FZR, Andersen S, AG N et al. The low-power laser in the treatment of tinnitus. Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 1999; 24: 346-354
  • 85 Teggi R, Bellini C, Piccioni L et al. Transmeatal Low-Level Laser Therapy for Chronic Tinnitus with Cochlear Dysfunction. Audiology & neuro-otology 2009; 14: 115-120
  • 86 Goodman SS, Bentler RA, Dittberner A et al. The effect of low-level laser therapy on hearing. ISRN Otolaryngol 2013; 2013: 916370
  • 87 Dejakum K, Piegger J, Plewka C et al. Medium-level laser in chronic tinnitus treatment. BioMed research international 2013; 2013: 324234
  • 88 Ngao CF, Tan TS, Narayanan P et al. The effectiveness of transmeatal low-power laser stimulation in treating tinnitus. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2014; 271: 975-980
  • 89 Mollasadeghi A, Mirmohammadi SJ, Mehrparvar AH et al. Efficacy of Low-Level Laser Therapy in the Management of Tinnitus due to Noise-Induced Hearing Loss: A Double-Blind Randomized Clinical Trial. ScientificWorldJournal 2013; 2013: 596076
  • 90 Kleinjung T, Steffens T, Langguth B et al. Neuronavigierte repetitive transkranielle Magnetstimulation (rTMS). HNO 2006; 54: 439-444
  • 91 Kleinjung T, Eichhammer P, Landgrebe M et al. Combined temporal and prefrontal transcranial magnetic stimulation for tinnitus treatment: A pilot study. Otolaryngol Head Neck Surg 2008; 138: 497-501
  • 92 Lee S, Abraham M, Cacace A et al. Repetitive transcranial magnetic stimulation in veterans with debilitating tinnitus: A pilot study. Otolaryng Head Neck 2008; 138: 398-399
  • 93 Piccirillo JF, Kallogjeri D, Nicklaus J et al. Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus: four-week stimulation trial. JAMA otolaryngology– head & neck surgery 2013; 139: 388-395
  • 94 Plewnia C, Vonthein R, Wasserka B et al. Treatment of chronic tinnitus with theta burst stimulation: A randomized controlled trial. Neurology 2012; 78: 1628-1634
  • 95 Hoekstra CE, Versnel H, Neggers SF et al. Bilateral low-frequency repetitive transcranial magnetic stimulation of the auditory cortex in tinnitus patients is not effective: a randomised controlled trial. Audiology & neuro-otology 2013; 18: 362-373
  • 96 Folmer RL, Theodoroff SM, Casiana L et al. Repetitive Transcranial Magnetic Stimulation Treatment for Chronic Tinnitus: A Randomized Clinical Trial. JAMA otolaryngology– head & neck surgery 2015; DOI: 10.1001/jamaoto.2015.1219.
  • 97 Chung H, Tsai C, Lin Y et al. Effectiveness of Theta-Burst Repetitive Transcranial Magnetic Stimulation for Treating Chronic Tinnitus. Audiology & neuro-otology 2012; 17: 112-120
  • 98 De Ridder D, Song J, Vanneste S. Frontal cortex TMS for tinnitus. Brain stimulation 2012; 6: 355-362
  • 99 Langguth B, Landgrebe M, Frank E, Schecklmann M, Sand PG, Vielsmeier V, Hajak G, Kleinjung T. Efficacy of different protocols of transcranial magnetic stimulation for the treatment of tinnitus: Pooled analysis of two randomized controlled studies. World J Biol Psychiatry 2014; 15: 276-285
  • 100 Burger J, Frank E, Kreuzer P et al. Transcranial magnetic stimulation for the treatment of tinnitus: 4-year follow-up in treatment responders-a retrospective analysis. Brain stimulation 2011; 4: 222-227
  • 101 Lehner A, Schecklmann M, Landgrebe M et al. Predictors for rTMS response in chronic tinnitus. Frontiers in systems neuroscience 2012; 6
  • 102 Bilici S, Yigit O, Taskin U et al. Medium-term results of combined treatment with transcranial magnetic stimulation and antidepressant drug for chronic tinnitus. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2015; 272: 337-343
  • 103 Peng Z, Chen X, Gong S. Effectivemess of Repetitive Transcranial Magnetic Stimulation for Chronic Tinnitus: A Systematic Review. Otolaryngol Head Neck Surg 2012; 147: 817-825
  • 104 Muller P, Pascual-Leone A, Rotenberg A. Safety and tolerability of repetitive transcranial magnetic stimulation in patients with pathologic positive sensory phenomena: a review of literature. Brain stimulation 2012; 5: 320-329
  • 105 Soleimani R, Jalali MM, Hasandokht T. Therapeutic impact of repetitive transcranial magnetic stimulation (rTMS) on tinnitus: a systematic review and meta-analysis. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2015; DOI: 10.1007/s00405-015-3642-5.
  • 106 Tringali S, Perrot X, Collet L et al. Repetitive Transcranial Magnetic Stimulation Noise Levels: Methodological Implications for Tinnitus Treatment. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2012; 33: 1156-1160
  • 107 Geven LI, de Kleine E, Willemsen AT et al. Asymmetry in primary auditory cortex activity in tinnitus patients and controls. Neuroscience 2014; 256: 117-125
  • 108 Nordmann G, Azorina V, Langguth B et al. A systematic review of non-motor rTMS induced motor cortex plasticity. Frontiers in human neuroscience 2015; 9: 416
  • 109 Lefaucheur JP, Andre-Obadia N, Antal A et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology 2014; DOI: 10.1016/j.clinph.2014.05.021.
  • 110 Kapkin O, Satar B, Yetiser S. Transcutaneous Electrical Stimulation of Subjective Tinnitus. A Placebo-Controlled, Randomized and Comparative Analysis. ORL J Otorhinolaryngol Relat Spec 2008; 70: 156-161
  • 111 Frank E, Schecklmann M, Landgrebe M et al. Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study. J Neurol 2011; 2 Epub ahead of print
  • 112 Garin P, Gilain C, Van Damme J et al. Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation. J Neurol 2011; 21 Epub ahead of print
  • 113 Vanneste S, Fregni F, De Ridder D. Head-to-Head Comparison of Transcranial Random Noise Stimulation, Transcranial AC Stimulation, and Transcranial DC Stimulation for Tinnitus. Front Psychiatry 2013; 4: 158
  • 114 Pal N, Maire R, Stephan MA et al. Transcranial Direct Current Stimulation for the Treatment of Chronic Tinnitus: A Randomized Controlled Study. Brain stimulation 2015; DOI: 10.1016/j.brs.2015.06.014.
  • 115 Shekhawat GS, Sundram F, Bikson M et al. Intensity, Duration, and Location of High-Definition Transcranial Direct Current Stimulation for Tinnitus Relief. Neurorehabilitation and neural repair 2015; DOI: 10.1177/1545968315595286.
  • 116 Minami SB, Oishi N, Watabe T et al. Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation. Acta oto-laryngologica 2015; DOI: 10.3109/00016489.2015.1068952. 1-7
  • 117 Pross SE, Allen CA, Hong OS et al. Willingness-to-accept Gamma knife radiosurgery for tinnitus among career San Francisco firefighters. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2014; 35: 1026-1032
  • 118 De Ridder D, Vanneste S, Kovacs S et al. Transcranial magnetic stimulation and extradural electrodes implanted on secondary auditory cortex for tinnitus suppression. Journal of neurosurgery 2011; 114: 903-911
  • 119 De Ridder D, Vanneste S, Plazier M et al. Dorsolateral Prefrontal Cortex Transcranial Magnetic Stimulation and Electrode implant for Intractable Tinnitus. World Neurosurg 2011; 77: 778-784
  • 120 Seidman M, De Ridder D, Elisevich K et al. Direct Electrical Stimulation of Heschl’s Gyrus for Tinnitus Treatment. The Laryngoscope 2007; Dec 18: Epub ahead of print
  • 121 Friedland D, Gaggl W, Runge-Samuelson C et al. Feasibility of Auditory Cortical Stimulation for the Treatment of Tinnitus. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2007; 28: 1005-1012
  • 122 Engelhardt J, Dauman R, Arne P et al. Effect of chronic cortical stimulation on chronic severe tinnitus: a prospective randomized double-blind cross-over trial and long-term follow up. Brain stimulation 2014; 7: 694-700
  • 123 Smit JV, Janssen ML, Schulze H et al. Deep brain stimulation in tinnitus: current and future perspectives. Brain research 2015; DOI: 10.1016/j.brainres.2015.02.050.
  • 124 Donovan C, Sweet J, Eccher M et al. Deep Brain Stimulation of Heschl Gyrus: Implantation Technique, Intraoperative Localization, and Effects of Stimulation. Neurosurgery 2015; DOI: 10.1227/NEU.0000000000000969.
  • 125 Coenen V, Amtage F, Volkmann J, Schläpfer TE. Tiefe Hirnstimulation bei neurologischen und psychiatrischen Erkrankungen. Dtsch Ärztebl Int 2015; 112: 519-526
  • 126 Engineer N, Riley J, Seale J et al. Reversing pathological neural activity using targeted plasticity. Nature 2011; 189: 207-214
  • 127 Kreuzer P, Landgrebe M, Husser O et al. Transcutaneous Vagus Nerve Stimulation: Retrospective Assessment of Cardiac Safety in a Pilot Study. Front Psychiatry 2012; 70 Epub ahead of print
  • 128 De Ridder D, Vanneste S, Engineer ND et al. Safety and efficacy of vagus nerve stimulation paired with tones for the treatment of tinnitus: a case series. Neuromodulation: journal of the International Neuromodulation Society 2014; 17: 170-179
  • 129 Clancy JA, Mary DA, Witte KK et al. Non-invasive Vagus Nerve Stimulation in Healthy Humans Reduces Sympathetic Nerve Activity. Brain stimulation 2014; DOI: 10.1016/j.brs.2014.07.031.
  • 130 De Ridder D, Kilgard M, Engineer N et al. Placebo-Controlled Vagus Nerve Stimulation Paired with Tones in a Patient with Refractory Tinnitus: A Case Report. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2015; DOI: 10.1097/MAO.0000000000000704.
  • 131 Rocha CB, Sanchez TG. Efficacy of myofascial trigger point deactivation for tinnitus control. Brazilian journal of otorhinolaryngology 2012; 78: 21-26
  • 132 Jeon S, Kim K, Nam H. Long-Term Effect of Acupuncture for Treatment of Tinnitus: A Randomized, Patient- and Assessor-Blind, Sham-Acupuncture-Controlled, Pilot Trial. J Altern Complement Med 2012; 18: 693-699
  • 133 Kim J, Choi J, Lee D et al. Acupuncture for the treatment of tinnitus: a systematic review of randomized clinical trials. BMC Complement Altern Med 2012; 12: 97
  • 134 Wang K, Bugge J, Bugge S. A randomised, placebo-controlled trial of manual and electrical acupuncture for the treatment of tinnitus. Complement Ther Med 2010; 18: 249-255
  • 135 Feldmann H. Kulturhistorisches und Medizinhistorisches zum Tinnitus Aurium. In Edition Medizin. Karlsruhe: HarschVerlag; 1989: 1-71
  • 136 Wazen J, Daugherty J, Pinsky K et al. Evaluation of a Customized Acoustical Stimulus System in the Treatment of Chronic Tinnitus. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2011; 32: 710-716
  • 137 Newman C, Sandridge S. A Comparison of Benefit and Economic Value between Two Sound Therapy Tinnitus Management Options. Journal of the American Academy of Audiology 2012; 23: 126-138
  • 138 Tass P, Popovych O. Unlearning tinnitus-related cerebral synchrony with acoustic coordinated reset stimulation: theoretical concept and modelling. Biol Cybern 2012; 106: 27-36
  • 139 Tass P, Adamchic I, Freund H et al. Counteracting tinnitus by acoustic coordinated reset neuromodulation. Restorative neurology and neuroscience 2012; 30: 137-159
  • 140 Hoare D, Kowalkowski V, Hall D. Effects of Frequency Discrimination Training on Tinnitus: Results form Two Randomised Controlled Trials. Journal of the Association for Research in Otolaryngology: JARO 2012; 13: 543-549
  • 141 Heijneman K, de Kleine E, van Dijk P. A Randomized Double-Blind Crossover Study of Phase-Shift Sound Therapy for Tinnitus. Otolaryngol Head Neck Surg 2012; 147: 308-315
  • 142 Reavis K, Rothholtz V, Tang Q et al. Temporary Suppression of Tinnitus by Modulated Sounds. Journal of the Association for Research in Otolaryngology: JARO 2012; 13: 561-571
  • 143 Hobson J, Chisholm E, El Refaie A. Sound therapy (masking) in the management of tinnitus in adults. Cochrane Database Syst Rev 2010; 12: 1-24
  • 144 Hoare DJ, Adjamian P, Sereda M et al. Recent technological advances in sound-based approaches to tinnitus treatment: A review of efficacy considered against putative physiological mechanisms. Noise Health 2013; 15: 107-116
  • 145 Sweetow RW. The use of fractal tones in tinnitus patient management. Noise Health 2013; 15: 96-100
  • 146 Cramer A. Tinnitus: Musiktherapie. Stuttgart: Trias; 2002
  • 147 Argstatter H, Plinkert PK, Bolay HV. Musiktherapie bei Tinnitus – Interdisziplonäre Pilotstudie zur Überprüfung des Heidelberger Modells. HNO 2007; 55: 375-383
  • 148 Argstatter H, Krick C, Bolay HV. Musiktherapie bei chronisch-tonalem Tinnitus. Heidelberger Modell evidenzbasierter Musiktherapie. HNO 2008; 56: 678-685
  • 149 Argstatter H, Grapp M, Hutter E et al. Long-term effects of the „Heidelberg Model of Music Therapy“ in patients with chronic tinnitus. Int J Clin Exp Med 2012; 5: 273-288
  • 150 Grapp M, Hutter E, Argstatter H et al. Music therapy as an early intervention to prevent chronification of tinnitus. International journal of clinical and experimental medicine 2013; 6: 589-593
  • 151 Krick CM, Grapp M, Daneshvar-Talebi J et al. Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy. Frontiers in neuroscience 2015; 9: 49
  • 152 Pantev C, Okamoto H, Teismann H. Tinnitus: the dark side of the auditory cortex plasticity. Annals of the New York Academy of Sciences 2012; 1252: 253-258
  • 153 Wilson E, Schlaug G, Pantev C. Listening to Filtered Music as a Treatment Option for Tinnitus: A Review. Music Percept 2010; 27: 327-330
  • 154 Teismann H, Okamoto H, Pantev C. Short and intense Tailor-made notched music training against tinnitus: Thre frequency matters. PloS one 2011; 6: e24685
  • 155 Pantev C, Okamoto H, Teismann H. Music-induced cortical plasticity and lateral inhibition in the human auditory cortex as foundations for tonal tinnitus treatment. Frontiers in systems neuroscience 2012; 6: 50
  • 156 Teismann H, Wollbrink A, Okamoto H et al. Combining transcranial direct current stimulation and tailor-made notched music training to decrease tinnitus-related distress – a pilot study. PloS one 2014; 9: e89904
  • 157 Pape J, Paraskevopoulos E, Bruchmann M et al. Playing and listening to tailor-made notched music: cortical plasticity induced by unimodal and multimodal training in tinnitus patients. Neural plasticity 2014; 2014: 516163
  • 158 Stein A, Engell A, Lau P et al. Enhancing inhibition-induced plasticity in tinnitus – spectral energy contrasts in tailor-made notched music matter. PloS one 2015; 10: e0126494
  • 159 Hesse G. Tinnitus. II. Aufl. Stuttgart: Thieme; 2015
  • 160 Trotter M, Donaldson I. Hearing aids and tinnitus therapy: a 25-year experience. The Journal of laryngology and otology 2008; 20: 1-5
  • 161 Wallhausser-Franke E, Repik I, Delb W et al. Long-term Development of Acute Tinnitus. Laryngo- rhino- otologie 2015; DOI: 10.1055/s-0035-1550039.
  • 162 Jalilvand H, Pourbakht A, Haghani H. Hearing Aid or Tinnitus Masker: Which One Is the Best Treatment for Blast-Induced Tinnitus? The Results of a Long-Term Study on 974 Patients. Audiology & neuro-otology 2015; 20: 195-201
  • 163 Forti S, Crocetti A, Scotti A et al. Tinnitus sound therapy with open ear canal hearing aids. B ENT 2010; 6: 195-199
  • 164 Parazzini M, Del Bo L, Jastreboff M et al. Open ear hearing aids in tinnitus therapy: An efficacy comparison with sound generators. International journal of audiology 2011; 50: 548-553
  • 165 Peltier E, Peltier C, Tahar S et al. Long-term tinnitus suppression with linear octave frequency transposition hearing AIDS. PloS one 2012; 7: e51915
  • 166 Shekhawat GS, Searchfield GD, Kobayashi K et al. Prescription of hearing-aid output for tinnitus relief. International journal of audiology 2013; DOI: 10.3109/14992027.2013.799787.
  • 167 Hoare DJ, Edmondson-Jones M, Sereda M et al. Amplification with hearing aids for patients with tinnitus and co-existing hearing loss. The Cochrane database of systematic reviews 2014; 1: CD010151
  • 168 Kloostra FJ, Arnold R, Hofman R et al. Changes in tinnitus after cochlear implantation and its relation with psychological functioning. Audiology & neuro-otology 2015; 20: 81-89
  • 169 Kim DK, Bae SC, Park KH et al. Tinnitus in patients with profound hearing loss and the effect of cochlear implantation. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2013; 270: 1803-1808
  • 170 Bovo R, Ciorba A, Martini A. Tinnitus and cochlear implants. Auris, nasus, larynx 2011; 38: 14-20
  • 171 Amoodi H, Mick P, Shipp D et al. The effects of unilateral cochlear implantation on the tinnitus handicap inventory and the influence on quality of life. The Laryngoscope 2011; 121: 1536t-1540t
  • 172 Olze H, Szczepek A, Haupt H et al. Cochlear implantation has a positive influence on quality of life, tinnitus, and psychological comorbidity. The Laryngoscope 2011; 121: 2220-2227
  • 173 Olze H, Szczepek A, Haupt H et al. The impact of Cochlear Implantation on Tinnitus, Stress and Quality of LIfe in Postlingually Deafened Patients. Audiology & neuro-otology 2012; 17: 2-11
  • 174 Olze H, Gräbel S, Haupt H et al. Extra benefit of a second cochlear implant with respect to health-related quality of life and tinnitus. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2012; 33: 1169-1175
  • 175 Kompis M, Pelizzone M, Dillier N et al. Tinnitus before and 6 Months after Cochlear Implantation. Audiology & neuro-otology 2012; 17: 161-168
  • 176 van Zon A, Smulders YE, Ramakers GG et al. Effect of unilateral and simultaneous bilateral cochlear implantation on tinnitus: A randomized controlled trial. The Laryngoscope 2015; DOI: 10.1002/lary.25493.
  • 177 Arndt S, Aschendorff A, Laszig R et al. Comparison of Pseudobinaural Hearing to Real Binaural Hearing Rehabilitation After Cochlear Implantation in Patients With Unilateral Deafness and Tinnitus. Otology & Neurotology 2010; 32: 39-47
  • 178 Arndt S, Laszig R, Aschendorff A et al. Einseitige Taubheit und Cochleaimplantat-Versorgung. HNO 2011; 59: 437-446
  • 179 Punte A, Vermeire K, Hofkens A et al. Cochlear implantation as a durable tinnitus treatment in single-sided deafness. Cochlear Implants Int 2011; 12: 26-29
  • 180 Vermeire K, Van de Heyning P. Binaural Hearing after Cochlear Implantation in Subjects with Unilateral Sensorineural Deafness and Tinnitus. Audiology & neuro-otology 2009; 14: 163-171
  • 181 Blasco MA, Redleaf MI. Cochlear implantation in unilateral sudden deafness improves tinnitus and speech comprehension: meta-analysis and systematic review. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2014; 35: 1426-1432
  • 182 Chang J, Zeng F. Tinnitus suppression by electric stimulation of the auditory nerve. Frontiers in systems neuroscience 2012; 6: 1-11
  • 183 Pichora-Fuller MK, Levitt H. Speech comprehension training and auditory and cognitive processing in older adults. American journal of audiology 2012; 21: 351-357
  • 184 Ptok M, Meyer S, Ptok A. Hearing training, hearing therapy and auditory rehabilitation in hearing impaired individuals during the last few centuries. HNO 2012; 60: 913-918
  • 185 Molloy K, Moore D, Sohoglu E et al. Less Is More: Latent Learning Is Maximized by Shorter Training Sessions in Auditory Perceptual Learning. PloS one 2012; 7: e36929
  • 186 Hesse G, Schaaf H. Manual der Hörtherapie. Stuttgart: Thieme; 2012
  • 187 Hesse G. Neurootologisch-psychosomatische Habituationstherapie. Therapieansätze bei chronischem Tinnitus. HNO 2008; 56: 686-693
  • 188 Guitton MJ. Telemedicine in tinnitus: feasibility, advantages, limitations, and perspectives. ISRN Otolaryngol 2013; 2013: 218265
  • 189 Jastreboff PJ, Hazell JWP. Treatment of tinnitus based on a neurophysiological model. Internetpräsentation 1996; DOI: 1-19.
  • 190 Jastreboff PJ. Tinnitus retraining therapy. Br J Audiol 1999; 33: 68-70
  • 191 Jastreboff PJ. 25 Years of tinnitus retraining therapy. HNO 2015; 63: 307-311
  • 192 Forti S, Costanzo k, Crocetti A et al. Are Results of Tinnitus Retraining Therapy Maintained over Time? 18-Month Follow-Up after Completion of Therapy. Audiology & neuro-otology 2009; 14: 286-289
  • 193 Oishi N, Shinden S, Kanzaki S et al. Effects of tinnitus retraining therapy involving monaural noise generators. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2012; 270: 443-448
  • 194 Bauer C, Brozoski T. Effect of Tinnitus Retraining Therapy on the Loudness and Annoyance of Tinnitus: A Controlled Trial. Ear and hearing 2010; 32: 145-155
  • 195 Madeira G, Montmirall C, Decat M et al. TRT: results after one year treatment. Rev Laryngol Otol Rhinol 2007; 127: 145-148
  • 196 Tyler R, Noble B, Coelho C et al. Tinnitus Retraining Therapy: Mixing Point and Total Masking Are Equally Effective. Ear and hearing 2012; 33: 588-594
  • 197 ADANO. Tinnitus-Retraining-Therapie (TRT/ADANO). In: ADANO-Sitzung. Hannover 2000: 1
  • 198 Seydel C, Haupt H, Szczepek A et al. Long-Term Improvement in Tinnitus after Modified Tinnitus Retraining Therapy Enhanced by a Variety of Psychological Approaches. Audiology & neuro-otology 2009; 15: 69-80
  • 199 Mazurek B, Fischer F, Haupt H et al. A Modified Version of Tinnitus Retraining Therapy: Observing Long-Term Outcome and Predictors. Audiology & neuro-otology 2006; 11: 276-286
  • 200 Seydel C, Haupt H, Szczepek AJ et al. Three years later: report on the state of well-being of patients with chronic tinnitus who underwent modified tinnitus retraining therapy. Audiology & neuro-otology 2015; 20: 26-38
  • 201 Cope T. Clinical hypnosis for the alleviation of tinnitus. Int Tinnitus J 2008; 14: 135-138
  • 202 Ross UH, Lange O, Unterrainer J et al. Ericksonian hypnosis in tinnitus therapy: effects of a 28-day inpatient multimodal treatment concept measured by Tinnitus-Questionnaire and Health Survey SF-36. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies 2007; 264: 483-488
  • 203 Pilgramm M, Liebisch H, Pehle W. Das ambulante Tinnitusbewältigungs- und Hyperakusistraining. HNO 2012; 60: 545-556
  • 204 Hesser H, Weise C, Westin V et al. A systematic review and meta-analysis of randomized controlled trials of cognitive-behavioral therapy for tinnitus distress. Clin Psychol Rev 2010; 31: 545-553
  • 205 Hesser H, Weise C, Rief W et al. The effect of waiting: A meta-analysis of wait-list control groups in trials for tinnitus distress. Journal of psychosomatic research 2011; 70: 378-384
  • 206 Robinson SK, Viirre ES, Bailey KA et al. A randomized controlled trial of cognitive-behavior therapy for tinnitus. The international tinnitus journal 2008; 14: 119-126
  • 207 McFerran DJ, Baguley DM. Is psychology really the best treatment for tinnitus?. Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 2009; 34: 99-101 discussion 102
  • 208 Cima R, Maes I, Joore M et al. Specialised treatment based on cognitive behaviour therapy versus usual car for tinnitus: a randomised controlled trial. Lancet 2012; 379: 1951-1959
  • 209 Maes IH, Cima RF, Anteunis LJ et al. Cost-effectiveness of specialized treatment based on cognitive behavioral therapy versus usual care for tinnitus. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2014; 35: 787-795
  • 210 Cima RF, Andersson G, Schmidt CJ et al. Cognitive-behavioral treatments for tinnitus: a review of the literature. Journal of the American Academy of Audiology 2014; 25: 29-61
  • 211 Heinecke K, Weise C, Rief W. Chronischer Tinnitus: Für wen ist eine ambulante Kurzzeitpsychotherapie indiziert?. Psychother Psych Med 2010; 60: 271-278
  • 212 Zenner HP, Vonthein R, Zenner B et al. Standardized tinnitus-specific individual cognitive-behavioral therapy: a controlled outcome study with 286 tinnitus patients. Hearing research 2013; 298: 117-125
  • 213 Nyenhuis N, Zastrutzki S, Weise C et al. The Efficacy of Minimal Contact Interventions for Acute Tinnitus: A Randomised Controlled Study. Cogn Behay Ther 2012; 13 Epub ahead of print
  • 214 Klug G, Henrich G. Chronic complex tinnitus: Does day care unit-based short-term psychotherapy help?. HNO 2014; DOI: 10.1007/s00106-014-2917-2.
  • 215 Andersson G, Cuijpers P, Carlbring P et al. Guided Internet-based vs. face-to-face cognitive behavior therapy for psychiatric and somatic disorders: a systematic review and meta-analysis. World psychiatry: official journal of the World Psychiatric Association 2014; 13: 288-295
  • 216 Schaaf H, Hesse G. Prä- und Post-Ergebnisse einer stationären neurootologisch fundierten und psychosomatischen Tinnitustherapie. HNO 2015; 63
  • 217 Herrmann C, Buss U, Snaith RP. HADS-D – Hospital Anxiety and Depression Scale – Deutsche Version: Ein Fragebogen zur Erfassung von Angst und Depressivität in der somatischen Medizin. Bern: Huber; 1995