Pneumologie 2016; 70(01): 17-22
DOI: 10.1055/s-0041-109601
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Tuberkulose und Rauchen

Tuberculosis and Tobacco Smoking
R. Loddenkemper
1   Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose, Berlin
,
M. Brönnecke
1   Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose, Berlin
,
S. Castell
1   Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose, Berlin
2   Abteilung für Epidemiologie, Helmholtz-Zentrum für Infektionsforschung, Braunschweig
,
R. Diel
1   Deutsches Zentralkomitee zur Bekämpfung der Tuberkulose, Berlin
3   Lungenclinic Grosshansdorf, Großhansdorf, Deutsches Zentrum für Lungenforschung (DZL), Universitäres Lungenzentrum Nord (ULZN)
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Publikationsverlauf

eingereicht 07. Oktober 2015

akzeptiert nach Revision 16. November 2015

Publikationsdatum:
20. Januar 2016 (online)

Zusammenfassung

Weltweit treten jährlich zirka 9,6 Millionen Neuerkrankungen und 1,5 Millionen Todesfälle durch Tuberkulose (TB) auf. Hierbei führt Rauchen als unabhängiger Risikofaktor etwa zu einer Verdoppelung des relativen Risikos nicht nur für die aktive Erkrankung, sondern auch für die latente TB-Infektion und die Sterblichkeit an TB. Nach einer Hochrechnung werden bis zum Jahr 2050 durch das Rauchen vermutlich 18 Millionen Neuerkrankungen an TB zusätzlich verursacht, womit das TB-Eliminierungsziel der WHO infrage gestellt würde. Maßnahmen zur Raucherentwöhnung während und nach der Therapie, die in Tuberkuloseprogrammen bislang unzureichend beachtet werden, sind daher dringend erforderlich.

Abstract

Worldwide there are annually about 9.6 million new cases and 1.5 million deaths due to tuberculosis (TB). Smoking is an independent risk factor causing approximately a twofold increase not only in active Tb disease but also in latent TB infection and mortality. In a mathematical model it is estimated that smoking would produce until 2050 an excess of 18 million tuberculosis cases from TB which would challenge the TB elimination goal of the WHO. Smoking cessation methods during and after TB treatment, which at present are insufficiently included into TB programmes, are urgently needed.

 
  • Literatur

  • 1 World Health Organisation. Global tuberculosis report 2015. WHO/HTM/TB/2015.22. Geneva: WHO; 2015
  • 2 Mackay J, Schluger N. Global tobacco epidemic. In: Loddenkemper R, Kreuter M, eds. The Tobacco Epidemic. ed 2, rev. and ext. Prog Respir Res. Basel: Karger; 2015. 42. 19-26
  • 3 Slama K, Chiang CY. Providing and monitoring quality service for smoking cessation in tuberculosis care. Int J Tuberc Lung Dis 2007; 11: 838-847
  • 4 Bates MN, Khaladina A, Pai M et al. Risk of tuberculosis from exposure to tobacco smoke. Arch Intern Med 2007; 167: 335-342
  • 5 Lin HH, Ezzati M, Murray M. Tobacco smoke, indoor air pollution and tuberculosis: a systematic review and meta-analysis. PLoS Med 2007; 4: e20
  • 6 World Health Organisation. A WHO/The Union monograph on TB and tobacco control: joining efforts to control two related epidemics. Geneva: WHO; 2007
  • 7 Enarson DA, Slama K, Chiang CY. Providing and monitoring quality service for smoking cessation in tuberculosis care. Int J Tuberc Lung Dis 2007; 11: 838-847
  • 8 Diel R, Loddenkemper R, Zellweger JP et al. European Forum for TB Innovation. Old ideas to innovate TB control: preventive treatment to achieve elimination. Eur Respir J 2013; 42: 785-801
  • 9 D’Ambrosio L, Dara M, Tadolini M et al. European national programme representatives. Tuberculosis elimination: theory and practice in Europe. Eur Respir J 2014; 43: 1410-1420
  • 10 Basu S, Stuckler D, Bitton A et al. Projected effects of tobacco smoking on worldwide tuberculosis control: mathematical modelling analysis. BMJ 2011; 4: 343
  • 11 van Zyl Smit RN, Pai M, Yew WW et al. Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD. Eur Respir J 2010; 35: 27-33
  • 12 Brauer L. Das Auftreten der Tuberkulose in Cigarrenfabriken. Beiträge zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung 1903; 1: 1-47
  • 13 Gesetzentwurf betreffend die Verhütung und Bekämpfung der Tuberkulose. Der Tabakgegner 1913; 2: 3
  • 14 Lickint F. Tabak und Organismus. Handbuch der gesamten Tabakkunde. Stuttgart: Hippokrates-Verlag Marquardt & Cie; 1939
  • 15 Lickint F. Tabakgenuß und Gesundheit. Hannover: Bruno Wilkens Verlag; 1940: 49-53
  • 16 Reichs-Tuberkulose-Ausschuß. Tuberkulose-Lexikon für Ärzte und Behörden. Leipzig: Thieme; 1943: 142
  • 17 Webb GB. The effect of the inhalation of cigarette smoke on the lungs. A clinical study. Am Rev Tuberc 1918; 1: 25-27
  • 18 Snider GL, Doctor L, Demas TA et al. Obstructive airway disease in patients with treated pulmonary tuberculosis. Am Rev Respir Dis 1971; 103: 625-640
  • 19 Christen AG, Swanson BZ, Glover ED et al. Smokeless tobacco: the folklore and social history of snuffing, sneezing, dipping, and chewing. J Am Dent Assoc 1982; 105: 821-829
  • 20 Bolinder G, Gilljam H. Smokeless tobacco – health hazards or less harm?. In: Loddenkemper R, Kreuter M, eds. The Tobacco Epidemic. ed 2, rev. and ext. Prog Respir Res. Basel: Karger; 2015. 42. 243-251
  • 21 Kluger R. Ashes to ashes: America’s hundred-year cigarette war, the public health, and the unabashed triumph of Philip Morris. New York: Vintage Books; 1997. zitiert in Leone FT, Douglas IS. The emergence of e-cigarettes: a triumph of wishful thinking over science. Ann Am Thorac Soc 2014; 11: 216–219
  • 22 Behr J, Nowak D. Tobacco smoke and respiratory disease. Eur Resp Mon 2002; 21: 161-179
  • 23 Lewis JG, Chamberlain DA. Alcohol consumption and smoking habits in male patients with pulmonary tuberculosis. Brit J Prev Soc Med 1963; 17: 149-152
  • 24 Brown KE, Campbell AH. Tobacco, alcohol and tuberculosis. Brit J Dis Chest 1961; 55: 150-158
  • 25 Zellweger JP. Tobacco and tuberculosis. Monaldi Arch Chest Dis 2008; 69: 83-85
  • 26 Yach D. Partnering for better lung health; improving tobacco and tuberculosis control. Int J Tuberc Lung Dis 2000; 4: 693-697
  • 27 Maurya V, Vijayan K, Shah A. Smoking and tuberculosis; an association overlooked. Int J Tuberc Lung Dis 2002; 6: 942-951
  • 28 Bates I, Fenton C, Gruber J et al. Vulnerability to malaria, tuberculosis, and HIV/AIDS infection and disease. Part 1: determinants operating at individual and household level. Lancet Infect Dis 2004; 4: 267-277
  • 29 Bothamley GH. Smoking and tuberculosis: a chance or causal association? Possible explanations for the association between smoking and tuberculosis (Editorial). Thorax 2005; 60: 527-528
  • 30 Slama K, Chiang C-Y, Enarson D. An educational series about tobacco cessation interventions for tuberculosis patients: what about other patients?. Int J Tuberc Lung Dis 2007; 11: 244
  • 31 Davies PD, Yew WW, Ganguly D et al. Smoking and tuberculosis: the epidemiological association and immunopathogenesis. Trans R Soc Trop Med Hyg 2006; 100: 291-298
  • 32 Van Zyl Smit RN, Pai M, Yew WW et al. Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD. Eur Respir J 2010; 35: 27-33
  • 33 U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. The health consequences of smoking – 50 years of progress: a report of the Surgeon General. Atlanta GA: 2014
  • 34 Houtmeyers E, Gosselink R, Gayan-Ramirez G et al. Regulation of mucociliary clearance in health and disease. Eur Respir J 1999; 13: 1177-1188
  • 35 Ernst JD. The immunological life cycle of tuberculosis. Nat Rev Immunol 2012; 12: 581-591
  • 36 Shang S, Ordway D, Henao-Tamayo M et al. Cigarette smoke increases susceptibility to tuberculosis – evidence from in vivo and in vitro models. J Infectious Dis 2011; 203: 1240-1248
  • 37 Sopori M. Effects of cigarette smoke on the immune system. Nat Rev Immunol 2002; 2: 372-377
  • 38 O’Leary SM, Coleman MM, Chew WM et al. Cigarette smoking impairs human pulmonary immunity to Mycobacterium tuberculosis. Am J Respir Crit Care Med 2014; 190: 1430-1436
  • 39 Van Zyl-Smit RN, Meldau R, Semple PL et al. Cigarette smoke impairs cytokine responses and BCG containment in alveolar macrophages. Thorax 2014; 69: 363-370
  • 40 Feng Y, Kong Y, Barnes PF et al. Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis. Infect Immun 2011; 79: 229-237
  • 41 Wang H, Yu M, Ochani M et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003; 421: 384-388
  • 42 Anderson RH, Sy FS, Thompson S et al. Cigarette smoking and tuberculin skin test conversion among incarcerated adults. Am Prev Med 1997; 13: 175-181
  • 43 Den Boon S, Van Lill SWP, Borgdorff MW et al. The association between smoking and tuberculosis infection: a population survey in a high tuberculosis incidence area. Thorax 2005; 60: 555-557
  • 44 Hussain H, Akthar S, Nanan D. Prevalence of and risk factors associated with Mycobacterium tuberculosis infection in prisoners, North West Frontier Province, Pakistan. Int J Epidemiol 2003; 32: 794-799
  • 45 Plant AJ, Watkins RE, Gushulak B et al. Predictors of tuberculin skin test reactivity among prospective Vietnamese migrants: the effects of smoking. Epidemiol Infect 2002; 128: 37-45
  • 46 Lindsay RP, Shin SS, Garfein RS et al. The association between active and passive smoking and latent tuberculosis infection in adults and children in the United States: Results from NHANES. PLoS ONE 2014; 9: e93137
  • 47 Dogar OF, Pillai N, Safdar N et al. Second-hand smoke and the risk of tuberculosis: a systematic review and a meta-analysis. Epidemiol Infect 2015; 29: 1-15
  • 48 Godoy P, Calya JA, Carmona G et al. Smoking in tuberculosis patients increases the risk of infection in their contacts. Int J Tuberc Lung Dis 2013; 17: 771-777
  • 49 Huang CC, Tchetgen ET, Becerra MC et al. Cigarette smoking among tuberculosis patients increases risk of transmission to child contacts. Int J Tuberc Lung Dis 2014; 18: 1285-1291
  • 50 Safdar N, Zahid R, Shah S et al. Tuberculosis patients learning about second-hand smoke (TBLASS): results of a pilot randomised controlled trial. Int J Tuberc Lung Dis 2015; 19: 237-243
  • 51 Altet-Gômez MN, Alcaide J, Godoy P et al. Clinical and epidemiological aspects of smoking and tuberculosis: a study of 13,038 cases. Int J Tuberc Lung Dis 2005; 9: 430-436
  • 52 Jee SH, Golub JE, Jo J et al. Smoking and risk of tuberculosis incidence, mortality, and recurrence in South Korean men and women. Am J Epidemiol 2009; 170: 1478-1485
  • 53 Lin HH, Ezzati M, Chang HY. Association between tobacco smoking and active tuberculosis in Taiwan. Am J Respir Crit Care Med 2009; 180: 475-480
  • 54 Leung CC, Lam TH, Ho KS et al. Passive Smoking and Tuberculosis. Arch Intern Med 2010; 170: 287-292
  • 55 Abal AT, Jayakrishnan B, Parwer S et al. Effect of cigarette smoking on sputum smear conversion in adults with active pulmonary tuberculosis. Respir Med 2005; 99: 415-420
  • 56 Maciel EL, Brioschi AP, Peres RL et al. Smoking and 2-month culture conversion during anti-tuberculosis treatment. Int J Tuberc Lung Dis 2013; 17: 225-228
  • 57 Nijenbandring de Boer R, Oliveira e Souza Filho JB, Cobelens F et al. Delayed culture conversion due to cigarette smoking in active pulmonary tuberculosis patients. Tuberculosis (Edinb) 2014; 94: 87-91
  • 58 d’Arc Lyra Batista J, de Fátima Pessoa Militão de Albuquerque M, de Alencar Ximenes RA et al. Smoking increases the risk of relapse after successful tuberculosis treatment. Int J Epidemiol 2008; 37: 841-851
  • 59 Leung CC, Li T, Lam TH et al. Smoking and tuberculosis among the elderly in Hong Kong. Am J Respr Crit Care Med 2004; 170: 1027-1033
  • 60 Thomas A, Gopi PG, Santha T et al. Predictors of relapse among pulmonary tuberculosis patients treated in a DOTS programme in South India. Inter J Tuberc Lung Dis 2005; 5: 5-25
  • 61 Yen YF, Yen MY, Lin YS et al. Smoking increases risk of recurrence after successful anti-tuberculosis treatment: a population-based study. Int J Tuberc Lung Dis 2014; 18: 492-498
  • 62 Leung CC, Yew WW, Chan CK et al. Smoking adversely affects treatment response, outcome and relapse in tuberculosis. Eur Respir J 2015; 45: 738-745
  • 63 Gajalakshmi V, Peto R, Kanaka TS et al. Smoking and mortality from tuberculosis and other diseases in India: retrospective study of 43 000 adult male deaths and 35 000 controls. Lancet 2003; 362: 507-515
  • 64 Peto R, Lopez AD. The future worldwide health effects of current smoking patterns. In: Koop CE, Pearson CE, Schwarz MR, eds. Critical issues in global health. San Francisco, CA: Jossey-Bass; 2000
  • 65 Jiménez-Ruiz CA, Andreas S, Lewis KE et al. Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit. Eur Respir J 2015; 46: 61-79
  • 66 Bam TS, Aditama TY, Chiang CY et al. Smoking cessation and smokefree environments for tuberculosis patients in Indonesia – a cohort study. BMC Public Health 2015; 15: 604
  • 67 Campbell IA, Chaudhary RD, Holdsworth GM et al. Brief advice to tuberculosis patients in Nepal to stop smoking: a pilot study by the Britain Nepal Medical Trust. Int J Tuberc Lung Dis 2014; 18: 1438-1442
  • 68 Louwagie GM, Okuyemi KS, Ayo-Yusuf OA. Efficacy of brief motivational interviewing on smoking cessation at tuberculosis clinics in Tshwane, South Africa: a randomized controlled trial. Addiction 2014; 109: 1942-1952
  • 69 Zellweger JP, Cattamanchi A, Sotgiu G. Tobacco and tuberculosis: could we improve tuberculosis outcomes by helping patients to stop smoking?. Eur Respir J 2015; 45: 583-585
  • 70 El Sony A, Slama K, Salieh M et al. Feasibility of brief tobacco cessation advice for tuberculosis patients: a study from Sudan. Int J Tuberc Lung Dis 2007; 11: 150-155
  • 71 Murray JF, Buist AS. Respiratory disorders related to smoking tobacco. In: Loddenkemper R, Kreuter M, eds. The tobacco epidemic. ed 2, rev. and ext. Prog Respir Res. Basel: Karger; 2015. 42. 72-84
  • 72 WHO End TB Strategy. Global strategy and targets for tuberculosis prevention, care and control after 2015. http://www.who.int/tb/post2015_strategy/en/