Antimikrobielle Peptid (AMP)-Forschung an der Kieler Universitäts-Hautklinik

Zusammenfassung

Antimikrobielle Peptide (AMPs) sind kleine körpereigene Proteine mit potenter antimikrobieller und auch immunmodulatorischer Aktivität. Eine Fehlregulation von AMPs wird in Verbindung mit diversen infektiösen und entzündlichen Krankheitsgeschehen gebracht. Die AMP-Forschung an der Kieler Universitäts-Hautklinik wurde Mitte der neunziger Jahre initiiert und vorangetrieben von Prof. Dr. rer. nat. Jens-Michael Schröder, der im Jahre 2015 pensioniert wurde. Im Laufe der Jahre konnten diverse neue AMPs entdeckt und charakterisiert werden sowie deren wichtige Rolle in der epithelialen Abwehr aufgedeckt werden, wodurch sich Kiel zu einem international renommierten AMP-Forschungsstandort etablieren konnte.

Abstract

Antimicrobial peptides (AMPs) are small endogeneous proteins exhibiting potent antimicrobial activity as well as immunomodulatory activites. A dysregulation of AMPs may be associated with several infectious and inflammatory diseases. AMP research at the Department of Dermatology in Kiel started in the mid 1990s and was initiated and driven by Prof. Dr. rer. nat. Jens-Michael Schröder who retired in 2015. Over the years the discovery and characterization of diverse novel AMPs as well as uncovering their important role in epithelial defense established Kiel as an international renowned AMP research site.

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