PDF icon Download PDF
Open Access
CC BY-NC-ND 4.0 · South Asian J Cancer 2020; 09(03): 158-162
DOI: 10.1055/s-0041-1723075
Original Article: Gastrointestinal Cancer

Preoperative Chemoradiation in Locally-Advanced Resectable Carcinoma of the Esophagus in a Single Rural Cancer Hospital in Western India

Yogesh S. Anap
1   Departments of Radiation Oncology, Kolhapur Cancer Centre, Karveer, Maharashtra, India
,
Prasad K. Tanawade
1   Departments of Radiation Oncology, Kolhapur Cancer Centre, Karveer, Maharashtra, India
,
Manish J. Mathankar
1   Departments of Radiation Oncology, Kolhapur Cancer Centre, Karveer, Maharashtra, India
,
Ashwini D. Mane-Patil
2   Departments of Pathology, Kolhapur Cancer Centre, Karveer, Maharashtra, India
,
Kiran G. Bagul
3   Departments of Surgical Oncology, Kolhapur Cancer Centre, Karveer, Maharashtra, India
,
Reshma S. Pawar
3   Departments of Surgical Oncology, Kolhapur Cancer Centre, Karveer, Maharashtra, India
,
Suraj B. Pawar
3   Departments of Surgical Oncology, Kolhapur Cancer Centre, Karveer, Maharashtra, India
› Author Affiliations
Financial Support and Sponsorship Nil.
› Further Information
Also available ateRef
  Permissions and Reprints
Preview

Abstract

Background The current standard of care for the treatment of surgically resectable carcinoma of the esophagus is preoperative chemoradiation followed by surgery. There is strong evidence that this trimodality approach improves survival as compared with surgery alone.

Objective The objective of this study is to determine the feasibility of this approach in a rural cancer institute in western India.

Materials and Methods The data of all the 157 consecutively treated patients with locally-advanced carcinoma of the esophagus from March 2013 to March 2017 who were started on preoperative chemoradiation were analyzed retrospectively.

Results Of the 157 patients who were started on preoperative chemoradiation, 68 patients underwent surgery. There are various practical reasons for not undergoing the definitive surgery, with the important being the socioeconomic support to the patients during the course of treatment.

Conclusion This study gave us insight into the strategic selection of patients for the trimodality approach as well as the need for continuous socioeconomic support throughout the treatment course.

Keywords

esophageal cancer - neoadjuvant chemoradiation - rural cancer hospital


Publication History

Article published online:
26 April 2021

© 2020. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68 (06) 394-424
    CrossrefPubMedSearch in Google Scholar
  • 2 Shapiro J, van Lanschot JJ, Hulshof MCC. et al; CROSS study group. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol 2015; 16 (09) 1090-1098
    CrossrefPubMedSearch in Google Scholar
  • 3 Urba SG, Orringer MB, Perez-Tamayo C, Bromberg J, Forastiere A. Concurrent preoperative chemotherapy and radiation therapy in localized esophageal adenocarcinoma. Cancer 1992; 69 (02) 285-291
    CrossrefPubMedSearch in Google Scholar
  • 4 Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996; 335 (07) 462-467
    CrossrefPubMedSearch in Google Scholar
  • 5 Bosset JF, Gignoux M, Triboulet JP. et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med 1997; 337 (03) 161-167
    CrossrefPubMedSearch in Google Scholar
  • 6 Burmeister BH, Smithers BM, Gebski V. et al; Trans-Tasman Radiation Oncology Group; Australasian Gastro-Intestinal Trials Group. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol 2005; 6 (09) 659-668
    CrossrefPubMedSearch in Google Scholar
  • 7 Tepper J, Krasna MJ, Niedzwiecki D. et al. Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol 2008; 26 (07) 1086-1092
    CrossrefPubMedSearch in Google Scholar
  • 8 Stahl M, Stuschke M, Lehmann N. et al. Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol 2005; 23 (10) 2310-2317
    CrossrefPubMedSearch in Google Scholar
  • 9 Lee MS, Mamon HJ, Hong TS. et al. Preoperative cetuximab, irinotecan, cisplatin, and radiation therapy for patients with locally advanced esophageal cancer. Oncologist 2013; 18 (03) 281-287
    CrossrefPubMedSearch in Google Scholar
  • 10 Krishnamurthy A, Mohanraj N, Radhakrishnan V, John A, Selvaluxmy G. Neoadjuvant chemoradiation for locally advanced resectable carcinoma of the esophagus: A single-center experience from India with a brief review of the literature. Indian J Cancer 2017; 54 (04) 646-651
    CrossrefPubMedSearch in Google Scholar