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CC BY 4.0 · Glob Med Genet 2021; 08(01): 001-006
DOI: 10.1055/s-0041-1723085
Review Article

Association of Assisted Reproductive Technology Treatments with Imprinting Disorders

T. Kopca
1   Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus
,
Pinar Tulay
1   Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus
2   Near East University, DESAM Institute, Nicosia, Cyprus
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Abstract

Assisted reproductive technology (ART) is a broad field in infertility that encompasses different types of treatments. These revolutionary treatment methods aimed to aid infertile or subfertile couples. Treatment was expanded exponentially, as 1 to 3% of the births worldwide takes place with ART procedures. However, treatment is not flawless. Gametes and embryos are exposed to different chemicals and stress through treatment, which leads to disturbance in proper embryo development and results in prenatal and congenital anomalies. When compared with in-vivo development of gametes and preimplantation embryos in mice, in-vitro conditions during ART treatments have been suggested to disturb the gene expression levels, especially imprinted genes. Therefore, ART has been suggested to be associated with increased incidences of different imprinting disorders such as Beckwith–Wiedemann syndrome, Angelman syndrome, and Silver–Russell syndrome, as proved by different case reports and studies. This literature review aims to explain the association of imprinting disorders with this revolutionary treatment procedure.

Keywords

assisted reproductive technology - imprinting disorders - IVF - epigenetics


Publication History

Article published online:
25 February 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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