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CC BY-NC-ND 4.0 · South Asian J Cancer 2020; 09(03): 153-157
DOI: 10.1055/s-0041-1723102
Original Article: Gastrointestinal Cancer

Hypervascular Nodules and Stiffer Liver are Associated with Recurrence after Microwave Ablation in Patients with Hepatocellular Carcinoma: A Double-Center Analysis

Mona A. H. Shehata
1   Department of Tropical Medicine and Infectious Disease, Tanta University, Tanta, Egypt
,
Nabeel El-Kady
2   Department of Tropical Medicine and Infectious Disease, Cairo University, Cairo, Egypt
,
Maha Hasaballah
2   Department of Tropical Medicine and Infectious Disease, Cairo University, Cairo, Egypt
,
Loai Mansour
1   Department of Tropical Medicine and Infectious Disease, Tanta University, Tanta, Egypt
,
Nabila El-Gazzar
1   Department of Tropical Medicine and Infectious Disease, Tanta University, Tanta, Egypt
,
Sherief Abd-Elsalam
1   Department of Tropical Medicine and Infectious Disease, Tanta University, Tanta, Egypt
› Author Affiliations Funding Nil.
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Abstract

Background and Aims The aim of this study was to detect the most important risk factors for recurrence after microwave ablation (MWA) of hepatocellular carcinoma (HCC).

Methods A total of 92 patients with 110 HCC focal lesions (FLs) underwent MWA therapy. All the patients underwent triphasic CT before and after 1 and 3 months of MWA therapy. Complete ablation and recurrence rates were recorded, and the risk factors associated with recurrence were analyzed.

Results Regarding the 110 HCC FLs that were detected pre-MWA, adequate ablation was recorded post-MWA procedure in 88 FLs (80%) and incomplete ablation in 22 FLs (showed residual contrast enhancement). However, there were newly detected lesions (17 FLs). The rate of recurrence was significantly higher in patients with multiple larger (> 4 cm) sized and hypervascular nodules. Diabetics were significantly associated with a higher recurrence rate of HCC. The rate of recurrence was significantly higher in patients with baseline level of serum alfa-fetoprotein (AFP) ≥200 ng/mL. Stiffer liver> 25 kPa had higher incidence for recurrence after ablation.

Conclusion Meticulous follow-up is mandatory in diabetic patients, patients with AFP > 200 ng/dL starting value, hypervascular large hepatic FL, and in stiffer liver> 25 kPa, as these patients have higher incidence for recurrence after ablation.

Keywords

hepatocellular carcinoma - microwave ablation - recurrence


Publication History

Article published online:
19 March 2021

© 2020. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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