Facial Plast Surg 2021; 37(02): 218-223
DOI: 10.1055/s-0041-1725107
Original Article

Theory and Evidence for Platelet Therapy of the Aging Face

1  Otolaryngology Head and Neck Surgery, Weill Cornell Medicine, New York, New York
Anthony P. Sclafani
2  Department of Otolaryngology, Head & Neck Surgery, Joan and Sanford I Weill Medical College of Cornell University, New York, New York
3  Department of Facial Plastic Surgery, Center for Facial Plastic Surgery, Chappaqua, New York
› Author Affiliations


Platelet preparations are autologous blood concentrates with supraphysiologic concentrations of platelets with or without leukocytes used in various clinical applications including regenerative medicine, wound healing, and facial rejuvenation. Their use harnesses the important role of platelets and their secretory products in immunoregulation, wound healing, angiogenesis, and tissue remodeling. The use of platelet preparations has been long documented in orthopaedic surgery, maxillofacial surgery, and other fields, but over the years research has increased in their application to facial plastic surgical techniques. Here we review the various formulations of platelet rich concentrates, their applications to facial skin rejuvenation, wound healing, scar reduction, and tissue fill as documented in the literature since 2018.

Publication History

Publication Date:
25 February 2021 (online)

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