CC BY 4.0 · Glob Med Genet 2021; 08(03): 095-099
DOI: 10.1055/s-0041-1725157
Original Article

Evaluation of Serum Immunoglobulins (IgG, IgA, IgM) and Circulating Immune Complexes in Oral Precancer and Cancer Patients

Pooja Madki
1  Department of Oral Medicine and Radiology, SB Patil Dental College and Hospital, Karnataka, India
Mandya Lakshman Avinash Tejasvi
2  Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
Geetha Paramkusam
3  Private Practice, Sri Venkateswara Dental Clinic, Hyderabad, Telangana, India
Ruheena Khan
4  Private Practice, Hyderabad, Telangana, India
Shilpa J.
4  Private Practice, Hyderabad, Telangana, India
› Author Affiliations
Funding None.


Objectives The aim of the present study is to evaluate the role of immunoglobulins (IgA, IgG, and IgM) and circulating immune complexes (CIC) as tumor marker in oral cancer and precancer patients.

Materials and Methods The present study was performed on 45 individuals subdivided into three groups, that is, oral precancer, oral cancer and healthy individuals, and levels of immunoglobulins, and CIC was estimated by turbidometry and ELISA method.

Results In the present study, the mean serum IgA levels in oral precancer were 161.00 ( ±  118.02) mg/dL, oral cancers were 270.67 ( ±  171.44) mg/dL, and controls were 133.73 ( ±  101.31) mg/dL. Mean serum levels of IgG in oral precancer were 1,430.87 ( ±  316) mg/dL, oral cancers were 1,234.27 ( ±  365.42) mg/dL, and controls were 593.87 ( ±  323.06) mg/dL.

Conclusion We found that the levels of serum IgG and IgA were elevated consistently in precancer and cancer group, and Serum IgM levels were increased only in precancer. Also, significant increase in serum CIC levels were seen in oral precancer and cancer group on comparison with control.

Publication History

Publication Date:
31 March 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (

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