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Lhermitte–Duclos Disease Mimicking Cerebellopontine Angle Tumor: A Case ReportFunding The pathological sections and images included in the present case study are supported by the Scientific Research Project (14A0230003).
Lhermitte-Duclos disease (LDD) is dysplastic gangliocytoma of the cerebellum, which is rare, tends to grow slowly, usually has good prognosis, and wherein the cerebellar cortex becomes thick and the central white matter is not observed. On MRI of the brain, it has hyperintense and hypointense presentations on T2- and T1-weighted scans, respectively. It has nonhomogenous contrasting pattern on T1-contrast scans. LDD can be seen unilaterally or bilaterally in the cerebellum. When the disease is located at the cerebellopontine angle, it can be mistaken for the tumors located in this region. Recurrence can occur postoperatively, which is rare. The present case is a rare one because the tumor was located at the cerebellopontine angle and radiologically mimicked cerebellopontine angle tumors.
15 July 2021 (online)
© 2021. Neurological Surgeons’ Society of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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- 1 Ma J, Jia G, Chen S, Jia W. Clinical perspective on dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). World Neurosurg 2019; 122: 16-23
- 2 Jain N, Chauhan U, Goel V, Puri SK. Lhermitte-Duclos disease: diagnosis on MRI, MR spectroscopy, CT and positron emission tomography. J Clin Diagn Res 2015; 9 (09) TJ01-TJ02
- 3 Cheng CS, Ou CH, Chen JS, Lui CC, Yeh LR. Lhermitte-Duclos disease: a case report with radiologic-pathologic correlation. Radiol Case Rep 2019; 14 (06) 734-739
- 4 Borni M, Kammoun B, Kolsi F, Abdelmouleh S, Boudawara MZ. The Lhermitte-Duclos disease: a rare bilateral cerebellar location of a rare pathology. Pan Afr Med J 2019; 33: 118
- 5 Ezgu MC, Ozer MI, Dogan A, Deveci G, Kural C, Izci Y. Lhermitte-Duclos disease in a six-year old child: a rare presentation. Pediatr Neurosurg 2018; 53 (06) 416-420
- 6 Wang Q, Zhang S, Cheng J, Liu W, Hui X. Lhermitte-Duclos disease: Clinical study with long-term follow-up in a single institution. Clin Neurol Neurosurg 2017; 162: 53-58
- 7 Wesseling P, Capper D. WHO 2016 Classification of gliomas. Neuropathol Appl Neurobiol 2018; 44 (02) 139-150
- 8 Önder E, Arikök AT, Türkoğlu E, Alper M. Lhermitte-Duclos disease: a rare lesion with variable presentations and obscure histopathology. Turk Patoloji Derg 2018; 34 (01) 92-99
- 9 Khandpur U, Huntoon K, Smith-Cohn M, Shaw A, Elder JB. Bilateral recurrent dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) in Cowden syndrome: a case report and literature review. World Neurosurg 2019; 127: 319-325
- 10 Friedmann DR, Grobelny B, Golfinos JG. Roland JT Jr. Nonschwannoma tumors of the cerebellopontine angle. Otolaryngol Clin North Am 2015; 48 (03) 461-475