Diabetologie und Stoffwechsel 2021; 16(S 01): S38
DOI: 10.1055/s-0041-1727390
05. Diabetes und Schwangerschaft

Differences in hemodynamic, hormonal and heart rate variability parameters in complication-free pregnancies, women with preeclampsia and women with gestational diabetes mellitus: an observational retrospective analysis

ML Eckstein
1   Universität Bayreuth, Division of Exercise Physiology and Metabolism, Bayreuth, Germany
,
A Rössler
2   Medizinische Universität Graz, Division of Physiology, Otto Loewi Research Center, Graz, Austria
,
M Moertl
3   Clinical Center Klagenfurt, Department of Obstetrics and Gynecology, Klagenfurt, Austria
,
A Jantscher
2   Medizinische Universität Graz, Division of Physiology, Otto Loewi Research Center, Graz, Austria
,
I Papousek
4   Universität Graz, Department of Psychology, Biological Psychology Unit, Graz, Austria
,
J Wagner
2   Medizinische Universität Graz, Division of Physiology, Otto Loewi Research Center, Graz, Austria
,
O Moser
1   Universität Bayreuth, Division of Exercise Physiology and Metabolism, Bayreuth, Germany
,
K Schmid-Zalaudek
5   Medizinische Universität Graz, Division of Exercise Physiology and Metabolism, Graz, Austria
,
H Sourij
6   Medizinische Universität Graz, Division of Endocrinology and Diabetology, Department of Internal Medicine, Graz, Austria
,
G Treiber
6   Medizinische Universität Graz, Division of Endocrinology and Diabetology, Department of Internal Medicine, Graz, Austria
,
H Lackner
5   Medizinische Universität Graz, Division of Exercise Physiology and Metabolism, Graz, Austria
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Background Pregnancy induces several physiological changes to a woman’s body which are poorly understood1,2. This study aimed to investigate differences in hemodynamic, hormonal and heart rate variability parameters (HRV) in women following complication-free pregnancies (healthy), preeclampsia and gestational diabetes mellitus (GDM) after giving childbirth.

Materials Retrospective data of 60 women (healthy: n = 29, age 32.7 ± 4 years, BMI 24.2 ± 4.3 kg / m2; preeclampsia: n = 16, age 35.3 ± 4.4 years, 28.5±6.4 kg / m2; GDM, n = 15, age 32.3±6.0 years, BMI 26.4 ± 6.2 kg / m2) were included. Two visits were conducted 16 and 48 weeks after giving childbirth. Hair samples were taken for analysis of cortisol and testosterone. ECG and continuous blood pressure were recorded with the Task Force Monitor®. Data were analysed via RM-ANOVA and post-hoc testing (p≤0.05).

Results Heart rate increased in groups between visits (p = 0.03) whereas SDNN decreased (p = 0.03), RMSSD showed only an increased trend for GDM (p = 0.07). In GDM testosterone was increased compared to other groups (Visit 1: healthy; preeclampsia; GDM: 0.8 ± 37; 0.86 ± 31; 1.27 ± 0.75 Visit 2: 0.88 ± 0.37; 0.86 ± 0.31; 1.27 ± 0.63 pg / mg) (for both visits p = 0.002). Cortisol levels were only different for GDM compared to healthy individuals (Visit 1: Healthy; GDM; 13.71 ± 6.25; 18.80 ± 9.61, Visit 2: 12.29 ± 5.11; 17.84 ± 10.08 pg / mg) (p = 0.02). Hemodynamic changes from week 16 to week 48 did not differ between groups. No differences between individuals with preeclampsia and healthy individuals were found for all parameters (p > 0.05).

Conclusion The study showed higher levels of chronic stress indicators in GDM compared to healthy women following childbirth. The trend found for heart rate variability (RMSSD) underpins the hormonal findings.



Publication History

Article published online:
06 May 2021

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