Synchronous occurrence of laryngeal papillomatosis and inverted papilloma of the nasal cavity

Introduction Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis (RRP), is caused by the Human Papilloma Virus (HPV). The role of HPV in the pathogenesis of sinonasal inverted papilloma is not yet fully understood. A synchronous occurrence was first described by Oliver et al. in 2019.

Case A 38-year-old man, without pre-existing conditions, was assigned to the clinic because of hoarseness that had been present for about 3 months, especially when speaking for a long time. Shortness of breath, foreign body sensation, dysphagia, or nasal breathing obstruction were negated. Clinically, exophytic, berry-like, whitish epithelial changes were found in the anterior and posterior third of the left vocal fold. In addition, an also berry-like mass with a stalk at the nasal septum in the right main nasal cavity was noticed.

A CT scan showed a bumpy soft tissue mass measuring approx. 1.5 cm x 1 cm, located dorsally in the middle nasal passage, which cannot be reliably separated from the nasal septum and the middle turbinates.

Complete excision of the intranasal and laryngeal masses was performed. Histopathological findings showed an inverted papilloma of the nasal cavity and a squamous epithelial papilloma of the larynx. Regular check-ups were recommended to the patient

Discussion RRP can be divided into juvenile-onset and adult-onset. Our patient is expected to have an adult-onset RRP. A synchronous occurrence of RRP and an inverted papilloma is very rarely described so far. It remains to be concluded that in the case of RRP or inverted papilloma a second manifestation site can always be excluded.

Poster-PDF A-1482.pdf

Publication History

Article published online:
13 May 2021