CC BY 4.0 · TH Open 2021; 05(02): e139-e142
DOI: 10.1055/s-0041-1728672
Letter to the Editor

Histone-DNA Complexes and Coagulation after Intracerebral and Subarachnoid Hemorrhage

Tua Gyldenholm
1  Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
,
1  Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
2  Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
,
Signe V. Lauridsen
3  Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark
,
Emilie Sandgaard
1  Thrombosis and Hemostasis Research Unit, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
,
Christine L. Hvas
3  Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark
› Author Affiliations
Funding This study received its financial support from Aarhus University, Aarhus, Denmark (project no. 18829), Oda and Hans Svenningsen's Foundation (grant no. BOF-10109), Helga and Peter Korning's Foundation (grant no. 55027-60) and Health Research Foundation of Central Denmark Region. The funding sources did not influence study design, data collection or analysis.

Introduction

Intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) have limited treatment options and a high mortality. We have previously shown that both conditions are associated with early hypercoagulation.[1] [2]

Histones have been demonstrated to promote thrombin generation.[3] In sepsis and trauma patients, studies have revealed an association between histone-DNA complexes and free histone levels and mortality or morbidity.[4] [5] [6] Theoretically, the effects on coagulation of histones can be investigated in vitro by attempting to block histones with specific antibodies.

The aim of this study was to quantify histone-DNA complex levels in patients with ICH or SAH at the time of admission to hospital compared with 24 hours after symptom onset and to investigate the possible in vitro effect of anti-histone antibodies on thrombin generation.



Publication History

Received: 15 November 2020

Accepted: 26 January 2021

Publication Date:
14 April 2021 (online)

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany