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CC BY 4.0 · Glob Med Genet 2021; 08(04): 156-161
DOI: 10.1055/s-0041-1731066
Original Article

Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism

Anjana Atteeri
1   Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
,
Praveen Kumar Neela
1   Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
,
Pavan Kumar Mamillapalli
1   Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
,
Vasu M. Sesham
1   Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
,
Sreekanth Keesara
1   Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
,
Jaya Chandra
1   Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
,
Udayini Monica
1   Department of Orthodontics, Kamineni Institute of Dental Sciences, Narketpally, Telangana, India
,
Vasavi Mohan
2   Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India
,
Shubhangi Miryala
2   Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India
,
Fatema A. Khan
2   Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India
,
Priyanka Makthal
2   Department of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, Telangana, India
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Abstract

Background Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the causal genes and variants responsible for the deformity remained ambiguous.

Aim This research work was aimed to study the association between polymorphism rs10850110 of the MYO1H gene and skeletal class-III malocclusion in our local population.

Materials and Methods Thirty patients with skeletal class III due to mandibular prognathism in the study group and 30 patients with skeletal class I in the control group were selected for this study. These patients were from both sexes and above age 10 years. Based on the cephalometric values, patients were categorized into study and control groups. SNB (angle between sella, nasion and point B at nasion) greater than 82 degrees with an ANB (angle between point A, nasion and point B at nasion) of less than 0 degrees in the study group and ANB (angle between point A, nasion and point B at nasion) of 2 to 4 degrees in the control group were categorized. The polymorphism (rs10850110) of the MYO1H gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism. Associations were tested with SNP exact test using SNPstats software.

Results The single-nucleotide polymorphism rs10850110 showed a statistically significant association with mandibular prognathism. The G allele of marker rs10850110 (5′ of myosin1H - MYO1H) was overrepresented when compared with the “A” allele in mandibular prognathism cases (p < 0.0001), and this was very significant.

Conclusion These results suggest that the rs10850110 polymorphism of the MYO1H gene is associated with an increased risk for mandibular prognathism.

Keywords

mandibular prognathism - gene - MYO1H


Publication History

Received: 25 March 2021

Accepted: 13 April 2021

Article published online:
25 June 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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