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CC BY-NC-ND 4.0 · South Asian J Cancer 2021; 10(02): 69-71
DOI: 10.1055/s-0041-1733350
Original Article: Cancer Epidemiology, Screening and diagnosis

Sentinel Lymph Node Biopsy Using a Single-Dye Technique in a Cancer Center of North-East India

Gaurav Das
1   Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Revanth Kodali
1   Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Sachin Khanna
1   Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Joydeep Purkayastha
1   Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Abhijit Talukdar
1   Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
,
Lopamudra Kakoti
2   Department of Oncopathology, Dr. B. Borooah Cancer Institute, Guwahati, Assam, India
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Abstract

Background Sentinel lymph node (SLN) is the first node to receive the drainage directly from a tumor. SLN biopsy can be done in lieu of a formal lymphadenectomy in selected clinically node-negative cancers and minimizes morbidity compared with the latter.

Methods This prospective study was done in patients with operable clinically node-negative breast cancer, penile cancer, and malignant melanoma of extremities in a cancer center of North-east India from January 2019 to December 2019. All the patients underwent formal lymph nodal dissection after the SLN biopsy. Besides intraoperative frozen section study of the sentinel node(s), all the specimens, including the sentinel node(s), were subjected to paraffin section histopathology.

Results SLN was identified successfully in 96% of patients. Mean number of sentinel node(s) dissected was 2.3. Study of SLN biopsy with methylene blue dye for staging was done with 100% sensitivity and 95.3% specificity. The SLN procedure was able to negatively predict the drainage nodal basin in 100% with an overall accuracy of staging of 96.5%. The true-positive rate noted was 88.8%, and the false-positive rate was 4.6%.

Conclusions SLN using a single-dye technique reliably identifies a sentinel node. This procedure can be safely adopted in patients with node-negative cancers as mentioned above to pathologically study the drainage basin.

Keywords

breast cancer - melanoma - methylene blue - penile cancer - sentinel node - single-dye technique


Publication History

Article published online:
04 September 2021

© 2021. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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