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Homeopathy 2022; 111(03): 226-231
DOI: 10.1055/s-0041-1734027
Hypothesis

Dengue Shock Syndrome: Its Similarity with Anaphylaxis and with the Homeopathic Medicine Apis mellifica (European Honeybee)

Cornelia Richardson-Boedler 
1   Berkeley, California, United States
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Abstract

Dengue, with four viral serotypes, causes epidemics in tropical and sub-tropical regions. Allopathic antiviral therapies and a vaccine of general use are lacking. The homeopathic medicine Apis mellifica, advised in anaphylaxis from honeybee sting, is proposed to address the life-threatening dengue shock syndrome, which develops from dengue hemorrhagic fever and has features of anaphylaxis. In both dengue and anaphylaxis, immunoglobulin E activates, and released vasoactive mediators (importantly histamine, tryptase and platelet-activating factor) cause, a vascular permeability enabling shock. In dengue, another mechanism, namely antibody-dependent enhancement, due to secondary infection with a heterologous dengue serotype, is associated with release of vasoactive mediators. The homeopathic medicine Apis mellifica indicates plasma leak, shock, and the serous effusion that is noted in dengue patients, and is a suggested prophylactic and therapeutic medicine for dengue shock syndrome.

Keywords

dengue shock syndrome - anaphylaxis - homeopathy - Apis mellifica


Publication History

Received: 30 April 2021

Accepted: 30 June 2021

Article published online:
08 November 2021

© 2021. Faculty of Homeopathy. This article is published by Thieme.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Bhatt S, Gething PW, Brady OJ. et al. The global distribution and burden of dengue. Nature 2013; 496: 504-507
    CrossrefPubMedGoogle Scholar
  • 2 Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 1998; 11: 480-496
    CrossrefPubMedGoogle Scholar
  • 3 Marino R. Homeopathy and collective health: the case of dengue epidemics. Int J High Dilution Res 2008; 7: 179-185
    CrossrefPubMedGoogle Scholar
  • 4 Weaver SC, Charlier C, Vasilakis N, Lecuit M. Zika, chikungunya, and other emerging vector-borne viral diseases. Annu Rev Med 2018; 69: 395-408
    CrossrefPubMedGoogle Scholar
  • 5 Tan VPK, Ngim CF, Lee EZ. et al. The association between obesity and dengue virus (DENV) infection in hospitalised patients. PLoS One 2018; 13: e0200698
    CrossrefPubMedGoogle Scholar
  • 6 Shyamali NLA, Mahapatuna SD, Gomes L, Wijewickrama A, Ogg GS, Malavige GN. Risk factors for elevated serum lipopolysaccharide in acute dengue and association with clinical disease severity. Trop Med Infect Dis 2020; 5: 170
    CrossrefPubMedGoogle Scholar
  • 7 Wilder-Smith A. Dengue vaccine development: status and future. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2020; 63: 40-44
    CrossrefPubMedGoogle Scholar
  • 8 Mahesh S, Mahesh M, Vithoulkas G. Could homeopathy become an alternative therapy in dengue fever? An example of 10 case studies. J Med Life 2018; 11: 75-82
    PubMedGoogle Scholar
  • 9 Nayak D, Chadha V, Jain S. et al. Effect of adjuvant homeopathy with usual care in management of thrombocytopenia due to dengue: a comparative cohort study. Homeopathy 2019; 108: 150-157
    Google Scholar
  • 10 de Souza Nunes LA. Contribution of homeopathy to the control of an outbreak of dengue in Macaé, Rio de Janeiro. Int J High Dilution Res 2008; 7: 186-192
    CrossrefPubMedGoogle Scholar
  • 11 Jacobs J, Fernandez EA, Merizalde B, Avila-Montes GA, Crothers D. The use of homeopathic combination remedy for dengue fever symptoms: a pilot RCT in Honduras. Homeopathy 2007; 96: 22-26
    Google Scholar
  • 12 Saeed-ul-Hassan S, Tariq I, Khalid A, Karim S. Comparative clinical study on the effectiveness of homeopathic combination remedy with standard maintenance therapy for dengue fever. Trop J Pharm Res 2013; 12: 767-770
    PubMedGoogle Scholar
  • 13 Koraka P, Murgue B, Deparis X. et al. Elevated levels of total and dengue virus-specific immunoglobulin E in patients with varying disease severity. J Med Virol 2003; 70: 91-98
    CrossrefPubMedGoogle Scholar
  • 14 King CA, Wegman AD, Endy TP. Mobilization and activation of the innate immune response to dengue virus. Front Cell Infect Microbiol 2020; 10: 574417
    CrossrefPubMedGoogle Scholar
  • 15 Jeewandara C, Gomes L, Wickramasinghe N. et al. Platelet activating factor contributes to vascular leak in acute dengue infection. PLoS Negl Trop Dis 2015; 9: e0003459
    CrossrefPubMedGoogle Scholar
  • 16 Cardosa J, Ooi MH, Tio PH. et al. Dengue virus serotype 2 from a sylvatic lineage isolated from a patient with dengue hemorrhagic fever. PLoS Negl Trop Dis 2009; 3: e423
    CrossrefPubMedGoogle Scholar
  • 17 Shivanthan MC, Navinan MR, Constantine GR, Rajapakse S. Cardiac involvement in dengue infection. J Infect Dev Countries 2015; 9: 338-346
    CrossrefPubMedGoogle Scholar
  • 18 Osnaya-Romero N, Perez-Guille MG, Andrade-García S. et al. Neurological complications and death in children with dengue virus infection: report of two cases. J Venom Anim Toxins Incl Trop Dis 2017; 23: 25
    CrossrefPubMedGoogle Scholar
  • 19 Abdulla MC, Alungal J, Nagabhushan KN, Narayan R. Dengue fever presenting as epididymo-orchitis. Indian J Health Sci Biomed Res 2016; 9: 322-323
    CrossrefPubMedGoogle Scholar
  • 20 Umakanth M. Dengue complicated with epididymo-orchitis, parotitis and rheumatoid like arthritis—case series. Sch J Med Case Rep 2018; 6: 62-65
    PubMedGoogle Scholar
  • 21 Wan SW, Wu-Hsieh BA, Lin YS, Chen WY, Huang Y, Anderson R. The monocyte-macrophage-mast cell axis in dengue pathogenesis. J Biomed Sci 2018; 25: 77
    CrossrefPubMedGoogle Scholar
  • 22 Méndez-Domínguez N, Achach-Medina K, Morales-Gual YM, Gómez-Carro S. Dengue with unusual clinical features in an infant: Case report. Rev Chil Pediatr 2017; 88: 275-279
    PubMedGoogle Scholar
  • 23 Ulrich H, Pillat MM, Tárnok A. Dengue fever, COVID-19 (SARS-CoV-2), and antibody-dependent enhancement (ADE): a perspective. Cytometry A 2020; 97: 662-667
    CrossrefPubMedGoogle Scholar
  • 24 Changal KH, Raina AH, Raina A. et al. Differentiating secondary from primary dengue using IgG to IgM ratio in early dengue: an observational hospital based clinico-serological study from North India. BMC Infect Dis 2016; 16: 715
    CrossrefPubMedGoogle Scholar
  • 25 Míguez-Burbano MJ, Jaramillo CA, Palmer CJ. et al. Total immunoglobulin E levels and dengue infection on San Andrés Island, Colombia. Clin Diagn Lab Immunol 1999; 6: 624-626
    CrossrefPubMedGoogle Scholar
  • 26 Tuchinda M, Dhorranintra B, Tuchinda P. Histamine content in 24-hour urine in patients with dengue haemorrhagic fever. Southeast Asian J Trop Med Public Health 1977; 8: 80-83
    PubMedGoogle Scholar
  • 27 Kien ND, El-Qushayri AE, Ahmed AM. et al. Association of allergic symptoms with dengue infection and severity: a systematic review and meta-analysis. Virol Sin 2020; 35: 83-92
    CrossrefPubMedGoogle Scholar
  • 28 Vadas P, Perelman B, Liss G. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. J Allergy Clin Immunol 2013; 131: 144-149
    CrossrefPubMedGoogle Scholar
  • 29 Vetter RS, Visscher PK. Bites and stings of medically important venomous arthropods. Int J Dermatol 1998; 37: 481-496
    CrossrefPubMedGoogle Scholar
  • 30 Rathore AP, Mantri CK, Aman SA. et al. Dengue virus-elicited tryptase induces endothelial permeability and shock. J Clin Invest 2019; 129: 4180-4193
    CrossrefPubMedGoogle Scholar
  • 31 Hahnemann S. Reine Arzneimittellehre. Vol. 3. 2nd ed.. Dresden: Arnoldische Buchhandlung; 1825
    Google Scholar
  • 32 Vetter RS, Visscher PK, Camazine S. Mass envenomations by honeybees and wasps. West J Med 1999; 170: 223-227
    PubMedGoogle Scholar
  • 33 Mingomataj EÇ, Bakiri AH. Episodic hemorrhage during honeybee venom anaphylaxis: potential mechanisms. J Investig Allergol Clin Immunol 2012; 22: 237-244
    PubMedGoogle Scholar
  • 34 Malavige GN, Ogg GS. Pathogenesis of vascular leak in dengue virus infection. Immunology 2017; 151: 261-269
    Google Scholar
  • 35 Barnard JH. Studies of 400 Hymenoptera sting deaths in the United States. J Allergy Clin Immunol 1973; 52: 259-264
    CrossrefPubMedGoogle Scholar
  • 36 Reisman RE. Natural history of insect sting allergy: relationship of severity of symptoms of initial sting anaphylaxis to re-sting reactions. J Allergy Clin Immunol 1992; 90: 335-339
    CrossrefPubMedGoogle Scholar
  • 37 Goddard J. Physician's Guide to Arthropods of Medical Importance. 6th ed.. Boca Raton, FL: CRC Press; 2013
    Google Scholar
  • 38 Morrison R. Desktop Guide to Keynotes and Confirmatory Symptoms. Albany, CA: Hahnemann Clinic Publishing; 1993
    Google Scholar
  • 39 Hering C. The Guiding Symptoms of Our Materia Medica. Vol. 1. Philadelphia: Estate of Constantine Hering; 1879
    Google Scholar
  • 40 Leeser O. Tierstoffe. 3rd ed.. In: Stübler M, Krug E. eds. Leesers Lehrbuch der Homöopathie. Vol. 5. Heidelberg, Germany: Karl F. Haug Verlag; 1987
    Google Scholar
  • 41 Metcalf JW. ed. Apis-mellifica. In: Homoeopathic Provings. New York: W. Radde; 1853: 184-203
    Google Scholar
  • 42 Manchanda RK. Dengue epidemic: What can we offer?. Indian J Res Homoeopathy 2015; 9: 137-140
    CrossrefPubMedGoogle Scholar
  • 43 Hering C. The Guiding Symptoms of Our Materia Medica. Vol. 3. Philadelphia: Estate of Constantine Hering; 1881
    Google Scholar
  • 44 Imhäuser H. Homöopathie in der Kinderheilkunde: Aus der Praxis—für die Praxis. 7th ed.. Heidelberg, Germany: Karl F Haug Verlag; 1985
    Google Scholar
  • 45 Richardson-Boedler C. The use of patient-made blood isodes (nosodes) in infectious diseases including HIV-infection. Hom Int 1994; 8: 21-23
    PubMedGoogle Scholar
  • 46 Jacobs J. Homeopathic prevention and management of epidemic diseases. Homeopathy 2018; 107: 157-160
    Google Scholar
  • 47 Kasozi KI, Niedbała G, Alqarni M. et al. Bee venom—a potential complementary medicine candidate for SARS-CoV-2 infections. Front Public Health 2020; 8: 594458
    CrossrefPubMedGoogle Scholar