Homeopathy
DOI: 10.1055/s-0041-1735235
Original Research Article

Randomized Double-Blind, Placebo-Controlled Feasibility Study, Evaluating the Efficacy of Homeopathic Medicines in the Prevention of COVID-19 in a Quarantined Population

Gitanjali Talele
1  Research Department, Life Force Foundation Trust, Chembur, Mumbai, Maharashtra, India
,
Shashikant Vaidhya
2  Haffkine Institute, Microbiology Department, Haffkine Institute for Training Research and Testing, Parel, Mumbai, Maharashtra, India
,
Abhay Chowdhary
3  Department of Microbiology, DY Patil University, Navi Mumbai, Maharashtra, India
,
Paul Herscu
4  Division of Research, Herscu Laboratory, Amherst, Massachusetts, United States
,
1  Research Department, Life Force Foundation Trust, Chembur, Mumbai, Maharashtra, India
› Author Affiliations
Funding None.

Abstract

Introduction Exploring preventive therapeutic measures has been among the biggest challenges during the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We explored the feasibility and methods of recruitment, retention, and potential signal of efficacy, of selected homeopathic medicines as preventive measure for developing COVID-19 in a multi-group study.

Materials and Methods A six-group, randomized, double-blind, placebo-controlled prophylaxis study was conducted in a COVID-19 exposed population in a quarantine facility in Mumbai, India. Each group received one of the following: Arsenicum album 30c, Bryonia alba 30c, a combination (Arsenicum album 30c, Bryonia alba 30c, Gelsemium sempervirens 30c, and Influenzinum 30c), coronavirus nosode CVN01 30c, Camphora 1M, or placebo. Six pills twice a day were administered for 3 days. The primary outcome measure used was testing recruitment and retention in this quarantined setting. Secondary outcomes were numbers testing positive for COVID-19 after developing symptoms of illness, number of subjects hospitalized, and days to recovery.

Results Good rates of recruitment and retention were achieved. Of 4,497 quarantined individuals, 2,343 sought enrollment, with 2,294 enrolled and 2,233 completing the trial (49.7% recruitment, 97.3% retention). Subjects who were randomized to either Bryonia alba or to the CVN01 nosode signaled (p <0.10) a lower incidence of laboratory-confirmed COVID-19 and a shorter period of illness, with evidence of fewer hospitalizations, than those taking placebo. The three other groups did not show signals of efficacy.

Conclusion This pilot study supports the feasibility of a larger randomized, double-blind, placebo-controlled trial. Bryonia alba 30c and CVN01 30c should both be explored in disease prevention or shortening the course of disease symptomatology in a COVID-19-exposed population.

Authors' Contributions

Gitanjali Talele of Life Force Foundation Trust assisted in research coordination and manuscript writing. Dr. Shashikant Vaidya and Dr. Abhay Chowdhary contributed toward nosode development, the study protocol, and manuscript review. Paul Herscu assisted in manuscript writing and statistical analysis. Rajesh Shah was the principal investigator and contributed toward the nosode development and manuscript writing.




Publication History

Received: 07 April 2021

Accepted: 22 May 2021

Publication Date:
30 September 2021 (online)

© 2021. Faculty of Homeopathy. This article is published by Thieme.

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