53 Distinct adipogenic and fibrogenic differentiation potentials in mesenchymal stromal cells from pancreas and white adipose tissue

Background

Apart from white adipose tissue (WAT), adipose accretion also occurs in non-adipose tissue, such as the pancreas. To date, the role of pancreatic fat cells in T2D development remains elusive. Recently, we reported that genetically diabetes-prone mice exhibit more pancreatic adipocytes than diabetes-resistant mice. Further we showed that co-culture of pancreatic islets and adipocytes derived from mesenchymal stromal cells (MSCs) of the pancreas and inguinal WAT (iWAT) results in hypersecretion of insulin. However, the role of pancreas MSCs in modulating organ health is still unclear. The aim of this study was to elucidate the transcriptional and regulatory differences, and downstream effects on differentiation capacities and organ function, between pancreas and iWAT MSCs.

Publication History

Article published online:
24 September 2021