Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematopoietic neoplasm
for which there are no effective therapies. We present a 70-year-old male patient
with multiple reddish painless, nonpruritic, and nonpedunculated nodules over the
trunk, forearm, and thighs for a duration of 3 months. The nodules measured 0.5 to
2 cm in diameter. The peripheral smear findings were within normal limits. Excision
biopsy was performed. Histomorphology and immunohistochemistry (CD123, CD 56, CD4,
HLA-DR, CD43, and CD68) confirmed the diagnosis of BPDCN. Findings of marrow aspiration,
biopsy and imaging studies were within normal limits. Patient demonstrated a good
response with complete disappearance of all nodules by initial 2 weeks of therapy
with a modified Berlin–Frankfurt–Munster (BFM) acute lymphoblastic leukemia (ALL)
protocol and has completed 8 doses (LSAP [lincosamides, streptogramins A and pleuromutilins
chemotherapy], 5,000 units/m2). The patient tolerated protocol extremely well.
Keywords
blastic plasmacytoid dendritic cell neoplasm - chemotherapy - stem cell therapy -
targeted therapy
