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CC BY 4.0 · Glob Med Genet 2022; 09(01): 004-006
DOI: 10.1055/s-0041-1736565
Review Article

A New Perspective of COVID-19 Infection: An Epigenetics Point of View

Ziya Ozturkler‡   *
1   Ministry of Education and Culture, Higher Education and Foreing Affairs Department, Turkish Republic of Northern Cyprus, Nicosia, Cyprus
,
Rasime Kalkan‡   *
2   Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Near East University, Nicosia, Cyprus
3   Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus
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Abstract

Coronavirus disease 2019 (COVID-2019) started in Wuhan, China, in December 2019. Angiotensin-converting enzyme 2 (ACE2) receptor was one of the most important genes related to the entrance of the virus to the host. Until now, several variations have been identified in ACE2 and related transmembrane protease serine 2. Epigenetic modifications not only play an important role during the maintenance of genome and cellular homoeostasis but also for the etiopathophysiology of the virus infection. Studies showed methylation of ACE2 was changed to depend on host and age of the host during the viral infection.

In this study, we provided an epigenetics point of view to the coronavirus infection. We highlight the importance of epigenetic modifications during viral replication and infection and their interaction with COVID-19 susceptibility and host viral response.

Keywords

COVID-19 - epigenetics - methylation

Authors' Contributions

R.K. was involved in project administration, conceptualization, data handling, writing, and reviewing, and Z.O. was involved in conceptualization and reviewing.


* These authors contributed equally to the work.




Publication History

Received: 01 July 2021

Accepted: 11 August 2021

Article published online:
19 October 2021

© 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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