Influence of TH-knockout in CD11b⁺ myeloid cells on bone and immune phenotype of male mice and its effects on stress-induced pathologies during fracture healing

Introduction

Chronic psychosocial stress is a risk factor for impaired fracture healing. Stress-induced synthesis of catecholamines by CD11b+myeloid cells locally in the fracture callus is assumed to contribute to delayed bone healing [1]. It was hypothesized that the knockout of tyrosine hydroxylase in CD11b+myeloid cells, the rate-limiting enzyme of catecholamine synthesis, improves impaired fracture healing in chronically stressed male mice. To analyze that, myeloid cell-specific TH-knockout (KO) mice were generated.

Publication History

Article published online:
04 November 2021

• References

• 1 Haffner-Luntzer et al. Proc Natl Acad Sci USA 2019; 116: 8615–8622