Osteologie 2021; 30(04): 342
DOI: 10.1055/s-0041-1736732
Abstract

Col22a1 deficiency leads to trabecular bone loss in mice

W Zhao
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
P Wiedemann
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
E M Wölfel
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
M Neven
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
S Peters
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
T Imhof
2   Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
3   Institute for Dental Research and Oral Musculoskeletal Biology, Medical Faculty, University of Cologne, Cologne, Germany
,
M Koch
2   Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
3   Institute for Dental Research and Oral Musculoskeletal Biology, Medical Faculty, University of Cologne, Cologne, Germany
,
B Busse
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
M Amling
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
T Schinke
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
,
T A Yorgan
1   Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
› Author Affiliations
› Further Information
 

Introduction

In an unbiased screening approach we identified Col22a1, encoding Collagen type XXII, as one of the most strongly induced genes during in vitro osteoblast differentiation [1]. Furthermore, expression of Col22a1 was determined to be highly specific for bone tissue. Col22a1 belongs to the FACIT family of collagens that does not form fibrils and has previously been identified mainly in tissue junctions [2]. Therefore, we aimed to explore its function in the skeleton.



Publication History

Article published online:
04 November 2021

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  • References

  • 1 Yorgan et al. Bone 2019; 127: 155–163. doi: 10.1016/j. bone.2019.06.008
  • 2 Koch et al. J Biol Chem 2004 May 21; 279(21): 22514–21. doi: 10.1074/ jbc.M400536200