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CC BY-NC-ND 4.0 · Revista Chilena de Ortopedia y Traumatología 2022; 63(01): e51-e54
DOI: 10.1055/s-0041-1739542
Artículo de Revisión | Review Article

Use of Denosumab in Aneurysmatic Bone Cyst: Literature Review

Article in several languages: español | English
Francisco de Assis Serra Baima Filho 
1   Departamento de Ortopedia y Traumatología, Subespecialidad en Ortopedia Oncológica, Universidade Federal do Maranhão (UFMA), São Luís, MA, Brasil
2   Hospital do Câncer Aldenora Bello, Fundação Antonio Dino, São Luís, MA, Brasil
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Abstract

Introduction Aneurysmal Bone Cysts (ABCs) are locally-aggressive benign tumors with relevant potential for recurrence, representing approximately 1% of all bone tumors. Multiple treatments are described for them, such as: intralesional excision, selective arterial embolization, injection of sclerosing agents, and radiation. These treatments have a variable efficacy rate, can reach 20% and may be associated with serious comorbidities such as functional loss of the limb.

Objective To perform an integrative review of the literature on the use of denosumab in the treatment of ABCs, describing the epidemiological profile, the dosage used, and the complications.

Methodology Articles published in the past five years were retrieved from the PubMed database. The information collected from the cases reported was age, gender, tumor location, the performance of surgery before and/or after the denosumab treatment, the dose used, the complications, and recurrence.

Results We analyzed 7 articles, 4 case reports and 3 case series, written in English, and published from 2014 to 2019. Most patients were female, with an average age of 14 years, with the tumor located in the spine.

Conclusion The use of denosumab in the treatment of ABCs yielded good results, with low rates of recurrence and complications. However, further studies are needed to define a treatment protocol.

Palabras Clave

quiste óseo aneurismático (MeSH ID: D017824) - denosumab (ID MeSH: 000069448) - revisión de la literatura (MeSH ID: D003211)


Publication History

Received: 15 October 2020

Accepted: 06 August 2021

Article published online:
20 January 2022

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