Subscribe to RSS
Getting Vaccinated Helps: Prospective Study Reveals Lower CT Severity Scores amongst COVID Vaccine RecipientsFunding None.
Context Computerized tomography (CT) is an invaluable imaging investigation for evaluating COVID-19 disease. CT detects early changes of COVID-19 pneumonia and predicts the disease prognosis based on a semiquantitative 25-point CT severity score (CT-SS). India launched its vaccination drive in January 2021 with two different vaccines being approved by the government. These vaccines are believed to prevent the disease itself, in majority of the cases and at least decrease disease severity, in the rest.
Aim This study aims to evaluate the CT-SS in vaccinated and non-vaccinated subjects who have been diagnosed with COVID-pneumonia or are COVID suspects.
Subjects and Methods A total of 3,235 patients with typical COVID-19 related imaging findings on HRCT thorax were included in the study. These subjects were divided into three age categories, 18–44, 45–59 and ≥60 years. The CT severity scores were allotted by experienced radiologists. Medians of the scores in different age groups were compared amongst vaccinated and non-vaccinated individuals using the Kruskal–Wallis H test. A p-value < 0.05 was considered significant. All results were shown with 95% confidence interval.
Results The difference in the medians amongst the vaccinated and non-vaccinated groups was significant, p-values being < 0.001 in all age categories.
Conclusion The mean CT-SS was less in vaccinated subjects and the difference in median CT-SS amongst vaccinated and non-vaccinated individuals was statistically significant, thus sending an important message that it is mandatory for the population at large to get vaccinated to reduce infection rate/disease severity.
The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s)has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published, and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Article published online:
10 January 2022
© 2022. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
- 1 CoWIN Dashboard [Internet]. [cited 2021 Jun 6]. Accessed September 9, 2021 from: https://dashboard.cowin.gov.in/
Administration of AstraZeneca COVID-19 Vaccine/COVISHIELD Vaccine.
Accessed September 9, 2021 from: https://www.health.gov.on.ca/en/pro/programs/publichealth/coronavirus/docs/vaccine/COVID-19_AstraZeneca_Vaccine_admin.pdf
- 3 Thiagarajan K. What do we know about India's Covaxin vaccine?. BMJ: British Medical Journal (Online) 2021; 20: 373
- 4 Corman VM, Landt O, Kaiser M. et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill 2020; 25 (03) 2000045 DOI: 10.2807/1560-7917.ES.2020.25.3.2000045.
- 5 Bernheim A, Mei X, Huang M. et al. Chest CT findings in coronavirus disease 2019 (COVID-19): Relationship to duration of infection. Radiology 2020; 295 (03) 200463
- 6 Liu J, Yu H, Zhang S. The indispensable role of chest CT in the detection of coronavirus disease 2019 (COVID-19). Eur J Nucl Med Mol Imaging 2020; 47 (07) 1638-1639
- 7 Simpson S, Kay FU, Abbara S. et al. Radiological Society of North America Expert Consensus Document on Reporting Chest CT Findings Related to COVID-19: Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA. Radiol Cardiothorac Imaging 2020; 2 (02) e200152
- 8 Malpani Dhoot N, Goenka U, Ghosh S. et al. Assigning computed tomography involvement score in COVID-19 patients: prognosis prediction and impact on management. BJR Open 2020; 2 (01) 20200024
- 9 Vaccines and immunization: What is vaccination? [Internet]. [cited 2021 Jun 6]. Accessed September 9, 2021 from: https://www.who.int/news-room/q-a-detail/vaccines-and-immunization-what-is-vaccination