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PSYCH up2date 2016; 10(02): 151-161
DOI: 10.1055/s-0042-100680
Störungsübergreifende Themen und Methoden

Effekte, Bedingungen und Anwendung von Placebos

Christoph Werner
,
Sebastian Hasler
,
Johanna Birkhäuer
,
Jens Gaab
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Kernaussagen

Placeboeffekte sind nicht nur eine Störgröße in wissenschaftlichen Wirksamkeitsuntersuchungen, sondern auch eine nicht zu vernachlässigende Wirkkomponente in Interventionen. Die Übersichtsarbeit stellt exemplarisch dar, unter welchen Bedingungen Placeboeffekte auftreten und wie diese in der klinischen Praxis berücksichtigt und ggf. genutzt werden könnten.



Publication History

Publication Date:
08 March 2016 (online)

© Georg Thieme Verlag KG
Stuttgart · New York

 

  • Literatur

  • 1 Pepper OHP. A note on the placebo. Ann J Pharm 1945; 117: 409-412
    Google Scholar
  • 2 Beecher HK. The powerful placebo. J Am Med Assoc 1955; 159: 1602-1606
    CrossrefPubMedGoogle Scholar
  • 3 Jones DS, Podolsky SH. The history and fate of the gold standard. Lancet 2015; 385: 1502-1503
    Google Scholar
  • 4 Hróbjartsson A, Gøtzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001; 344: 1594-1602
    CrossrefPubMedGoogle Scholar
  • 5 Hróbjartsson A, Gøtzsche PC. Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010; 1: CD003974
    Google Scholar
  • 6 Levine JD, Gordon NC, Fields HL. The mechanism of placebo analgesia. Lancet 1978; 312: 654-657
    CrossrefPubMedGoogle Scholar
  • 7 de la Fuente-Fernandez R, Ruth TJ, Sossi V. et al. Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease. Science 2001; 293: 1164-1166
    CrossrefPubMedGoogle Scholar
  • 8 Lidstone SC, Schulzer M, Dinelle K. et al. Effects of expectation on placebo-induced dopamine release in Parkinson disease. Arch Gen Psychiatry 2010; 67: 857-865
    CrossrefPubMedGoogle Scholar
  • 9 Brunoni AR, Lopes M, Kaptchuk TJ. et al. Placebo response of non-pharmacological and pharmacological trials in major depression: a systematic review and meta-analysis. PloS One 2009; 4: e4824
    CrossrefPubMedGoogle Scholar
  • 10 Benedetti F, Lanotte M, Colloca L. et al. Electrophysiological properties of thalamic, subthalamic and nigral neurons during the anti-parkinsonian placebo response. J Physiol 2009; 587: 3869-3883
    CrossrefPubMedGoogle Scholar
  • 11 Kaptchuk TJ, Kelley JM, Deykin A. et al. Do “placebo responders” exist?. Contemp Clin Trials 2008; 29: 587-595
    CrossrefPubMedGoogle Scholar
  • 12 Peciña M, Azhar H, Love TM. et al. Personality trait predictors of placebo analgesia and neurobiological correlates. Neuropsychopharmacol 2013; 38: 639-646
    CrossrefPubMedGoogle Scholar
  • 13 Darragh M, Booth RJ, Consedine NS. Investigating the ‘placebo personality’outside the pain paradigm. J Psychosom Res 2014; 76: 414-421
    CrossrefPubMedGoogle Scholar
  • 14 Hall KT, Lembo AJ, Kirsch I. et al. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS One 2012; 7: e48135
    CrossrefPubMedGoogle Scholar
  • 15 Finniss DG, Kaptchuk TJ, Miller F. et al. Biological, clinical, and ethical advances of placebo effects. Lancet 2010; 375: 686-695
    CrossrefPubMedGoogle Scholar
  • 16 Benedetti F. The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain 1996; 64: 535-543
    CrossrefPubMedGoogle Scholar
  • 17 Scott DJ, Stohler CS, Egnatuk CM. et al. Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch Gen Psychiatry 2008; 65: 220-231
    CrossrefPubMedGoogle Scholar
  • 18 Mayberg HS, Silva JA, Brannan SK. et al. The functional neuroanatomy of the placebo effect. Am J Psychiatry 2002; 159: 728-737
    CrossrefPubMedGoogle Scholar
  • 19 Rief W, Nestoriuc Y, von Lilienfeld-Toal A. et al. Differences in adverse effect reporting in placebo groups in SSRI and tricyclic antidepressant trials: a systematic review and meta-analysis. Drug Safety 2009; 32: 1041-1056
    CrossrefPubMedGoogle Scholar
  • 20 Kessner S, Sprenger C, Wrobel N. et al. Effect of oxytocin on placebo analgesia: a randomized study. J Am Med Assoc 2013; 310: 1733-1735
    CrossrefPubMedGoogle Scholar
  • 21 Jensen KB, Petrovic P, Kerr CE. et al. Sharing pain and relief: neural correlates of physicians during treatment of patients. Mol Psychiatry 2014; 19: 392-398
    CrossrefPubMedGoogle Scholar
  • 22 Enck P, Bingel U, Schedlowski M. et al. The placebo response in medicine: minimize, maximize or personalize?. Nat Rev Drug Discov 2013; 12: 191-204
    CrossrefPubMedGoogle Scholar
  • 23 Moseley JB, O'Malley K, Petersen NJ. et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002; 347: 81-88
    CrossrefPubMedGoogle Scholar
  • 24 Fournier JC, DeRubeis RJ, Hollon SD. et al. Anti-depressant drug effects and depression severity: a patient-level meta-analysis. J Am Med Assoc 2010; 303: 47-53
    CrossrefPubMedGoogle Scholar
  • 25 Gaab J, Blease C, Locher C. et al. Go open: A plea for transparency in psychotherapy. Psychology of Consciousness: Theory, Research, and Practice 2015; DOI: 10.1037/cns0000063.
    CrossrefGoogle Scholar
  • 26 Sandler AD, Glesne CE, Bodfish JW. Conditioned placebo dose reduction: a new treatment in attention-deficit hyperactivity disorder?. J Dev Behav Pediatr 2010; 31: 369-375
    CrossrefPubMedGoogle Scholar
  • 27 Doering BK, Rief W. Utilizing placebo mechanisms for dose reduction in pharmacotherapy. Trends Pharmacol Sci 2012; 33: 165-172
    CrossrefPubMedGoogle Scholar
  • 28 Sandler A, Glesne C, Geller G. Children’s and parents’ perspectives on open-label use of placebos in the treatment of ADHD. Child Care Health Dev 2008; 34: 111-120
    PubMedGoogle Scholar
  • 29 Kaptchuk TJ, Friedlander E, Kelley JM. et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One 2010; 5: e15591
    CrossrefPubMedGoogle Scholar
  • 30 Fässler M, Meissner K, Schneider A. et al. Frequency and circumstances of placebo use in clinical practice – a systematic review of empirical studies. BMC Med 2010; 8: 15
    CrossrefPubMedGoogle Scholar
  • 31 Howick J, Bishop FL, Heneghan C. et al. Placebo use in the United Kingdom: results from a national survey of primary care practitioners. PLoS One 2013; 8: e58247
    CrossrefPubMedGoogle Scholar