ABC3 Consensus Commented from the Perspective of the German Guidelines^[*]

Abstract

The Third International Consensus Conference for Advanced Breast Cancer ABC3 on the diagnosis and treatment of advanced breast cancer was held in Lisbon from 5 to 7 November 2015. This year the focus was the treatment of metastatic breast cancer (stage IV) – including the patient perspectives. Important topics were questions relating to quality of life, the care for long-term survivors as well as the management of disease-related symptoms and treatment-based side effects. The use of standardised tools to assess individual treatment success and the benefits of new substances were important points for discussion. The diagnosis and treatment of inoperable locally advanced breast cancer were discussed two years ago during the ABC2 consensus [1]. A working group of German breast cancer experts commented on the results of the ABC panellists, paying particular attention to the German guidelines (AGO, S3, DGHO) on the diagnosis and treatment of breast cancer [2], [3], [4], [5] in Germany.

Zusammenfassung

Vom 05. bis 07. November 2015 fand in Lissabon die 3. internationale Konsensuskonferenz ABC3 (Advanced Breast Cancer Third Consensus) zu Diagnostik und Behandlung des fortgeschrittenen Mammakarzinoms statt. Der inhaltliche Schwerpunkt lag dieses Jahr auf der Behandlung des metastasierten Mammakarzinoms (Stadium IV) – u. a. unter besonderer Berücksichtigung der Perspektive der Patientinnen. Im Rahmen der Konsensusdiskussion wurde daher auch über Fragestellungen zur Lebensqualität, der Betreuung Langzeitüberlebender sowie des Umgangs mit erkrankungsbedingten Symptomen und therapiebedingten Nebenwirkungen abgestimmt. Neben den klassischen medizinischen Fragestellungen waren der Einsatz standardisierter Instrumente zur Bewertung des individuellen Therapieerfolgs sowie die Nutzenbewertung neuer Substanzen wichtige Diskussionspunkte. Diagnostik und Therapie des inoperablen lokal fortgeschrittenen Mammakarzinoms waren vor 2 Jahren anlässlich des ABC2-Konsensus diskutiert worden [1]. Eine Arbeitsgruppe deutscher Brustkrebsexperten hat die Abstimmungsergebnisse der ABC-Panelisten unter besonderer Berücksichtigung der deutschen Leitlinien (AGO, S3, DGHO) zu Diagnostik und Therapie des Mammakarzinoms [2], [3], [4], [5] für den Therapiealltag in Deutschland kommentiert.

Key words

ABC3 Consensus - Metastatic breast cancer - System therapy - Guidelines

Schlüsselwörter

ABC3-Konsensus - metastasiertes Mammakarzinom - Systemtherapie - Leitlinien

^* The present manuscript (modified version) is a cross-section of opinions from the point of view of German breast cancer experts. The first publication was in “Breast Care” 01/2016 (Thomssen C, Augustin D, Ettl J et al., ABC3-Consensus: assessment by a German group of experts. DOI: 10.1159/000443515). The official ABC3 consensus will be published under the authorship of the ABC3 panelists.

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