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Exp Clin Endocrinol Diabetes 2016; 124(05): 283-287
DOI: 10.1055/s-0042-101243
Article
© Georg Thieme Verlag KG Stuttgart · New York

Arterial Stiffness, BMI, Dipping Status and ACE D/I Polymorphism in Type 1 Diabetic Children

I. Pietrzak
1   Department of Pediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Łódź, Poland
,
W. Fendler
2   Medical University of Lodz, Łódź, Poland
,
I. Dróżdż
2   Medical University of Lodz, Łódź, Poland
,
B. Mianowska
2   Medical University of Lodz, Łódź, Poland
,
W. Młynarski
2   Medical University of Lodz, Łódź, Poland
,
A. Szadkowska
2   Medical University of Lodz, Łódź, Poland
› Author Affiliations
Further Information

Publication History

received 05 November 2015
first decision 05 January 2016

accepted 20 January 2016

Publication Date:
06 April 2016 (online)

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Abstract

The aim: of the study was to investigate clinical and genetic determinants of arterial stiffness in children and adolescents with type 1 diabetes mellitus.

Material and Methods: 122 patients (mean age: 16.0±2.35 years), with an average diabetes duration of 5.0 years and without evidence of arterial hypertension were recruited. Ambulatory arterial stiffness index (AASI) was assessed with 24-h automatic blood pressure monitoring. Body weight, height, HbA1c and plasma lipids were measured. Angiotensin I converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism was analysed.

Results: Mean AASI equalled 0.22±0.20 and showed significant, positive correlation with age and BMI-SDS. No association was found between AASI and gender, diabetes duration, daily insulin dose, HbA1c and blood lipids concentration. AASI was higher in non-dippers compared to dippers (0.26±0.18 vs. 0.19±0.18, respectively; p=0.04). In a multivariate model AASI was significantly associated with II homozygosity of ACE gene (p=0.007).

Conclusions: In type 1 diabetic children and adolescents AASI is correlated with age and BMI-SDS. Non-dipping status and I-allele were associated with higher arterial stiffness.

Key words

diabetes - cardiovascular risk management - obesity
 

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