Ultraschall in Med 2017; 38(04): 443-445
DOI: 10.1055/s-0042-108056
Case Report
© Georg Thieme Verlag KG Stuttgart · New York

Neuroblastoma in a Newborn – An Easily Overlooked Entity

Neuroblastom bei Neugeborenen
Karl Otto Schneider
Pediatric Radiology, Klinikum der Universität München, Munich, Germany
Orsolya Genzel-Boroviczény
Neonatology, Klinikum der Universität München, Munich, Germany
Irene Schmid
Pediatric Oncology, Klinikum der Universität München, Munich, Germany
› Author Affiliations
Further Information

Publication History

16 November 2015

29 April 2016

Publication Date:
07 September 2016 (eFirst)


Neuroblastoma is the most frequent malignant tumor in early life. Neuroblastomas may be present in situ in microscopic size in fetuses and neonates dying of other diseases. Most of these precursors of malignant neuroblastoma will disappear within the first three months of life (Beckwith JB, Perrin EV. Amer J Path 1963; 43:1089 – 1104). The great majority of neuroblastomas diagnosed prenatally and in newborns occur in the adrenals (Isaacs H. Fetal and Pediatric Pathology 2007; 26: 177 – 184). Tumors in the adrenal glands are easily detected with prenatal ultrasound (US) or magnetic resonance imaging (MRI). Other sites of this tumor in early life are in the neck, in the chest following the developing sympathetic chain and in the retroperitoneal space associated with the sympathetic para-aortic trunks.