Exp Clin Endocrinol Diabetes 2017; 125(02): 86-90
DOI: 10.1055/s-0042-114220
Article
© Georg Thieme Verlag KG Stuttgart · New York

The Relationship between Metabolic Parameters, Cardiac Parameters and MIC-1/GDF15 in Obese Children

S. A. Yuca
1   Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey
,
E. A. Cimbek
1   Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey
,
Y. Şen
1   Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey
,
O. Güvenç
2   Department of Pediatric Cardiology, Selçuk University Medical School, Selçuklu, Turkey
,
H. Vatansev
3   Department of Biochemistry, Selçuk University Medical School, Selçuklu, Turkey
,
F. Buğrul
1   Department of Pediatric Endocrinology, Selçuk University Medical School, Selçuklu, Turkey
,
F. Gün
3   Department of Biochemistry, Selçuk University Medical School, Selçuklu, Turkey
,
B. Oran
2   Department of Pediatric Cardiology, Selçuk University Medical School, Selçuklu, Turkey
› Author Affiliations
Further Information

Publication History

received 07 January 2016
revised 21 July 2016

accepted 02 August 2016

Publication Date:
17 October 2016 (online)

Abstract

Objective: Childhood obesity which is a predictor of adulthood obesity is associated with type 2 diabetes, metabolic syndrome, dyslipidemia, coronary artery diseases and subclinical inflammation. Growth differentiation factor-15, also known as macrophage inhibitory cytokine-1 (MIC-1/GDF15) is a member of the transforming growth factor- β super family and increases during inflammatory states. Adults with obesity have increased serum concentrations of MIC-1/GDF15. MIC-1/GDF15 is associated with cardio metabolic risk in adults.

Design: Identification of obese children at higher risk for cardio metabolic complications is important. The relations of MIC-1/GDF15 to parameters of obesity in children have never been studied.

Methods: We measured serum MIC-1/GDF15 concentration in obese children by ELİSA and evaluated its relationship with anthropometric, biochemical and echocardiographic parameters.

Results: No significant difference in serum MIC-1/GDF15 between normal-weight and obese children was observed. MIC-1/GDF15 was positively correlated with CRP, ALT and aortic dimension when normal-weight and obese children were analyzed together.

Conclusions: MIC-1/GDF15 may provide a link between childhood obesity and cardio metabolic complications that will occur in time course. Further work would be required to find out if MIC-1/GDF15 has any role in the early inflammatory, cardiac and metabolic changes in childhood obesity.

 
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