Int J Sports Med 2017; 38(1): 27-34
DOI: 10.1055/s-0042-115567
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Effects of pericardiectomy on training- and myocardial infarction-induced left ventricular hypertrophy, chamber dimensions and gene expression

A. M. Wolff1, 2, *, T. P. Rasmussen1, *, C. R. Wichern1, M. R. Peterson1, M. M. Stayton2, D. P. Thomas1
  • 1Division of Kinesiology & Health
  • 2Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
Further Information

Publication History

accepted after revision 08 September 2016

Publication Date:
13 October 2016 (eFirst)


The primary purpose of the study was to evaluate whether a pericardiectomy (PERI) alters training- or myocardial infarction (MI)-induced left ventricular hypertrophy (LVH), chamber geometry, gene expression and/or running performance. Mice were randomized into 6 groups: naïve control (CONT)-sedentary (Sed), CONT-trained (Tr), PERI-Sed, PERI-Tr, MI-Sed and MI-Tr. MI mice also received a pericardiectomy as part of the MI surgical procedure. 10 weeks of treadmill running resulted in enhanced running performance-to-exhaustion in all 3 trained groups (CONT-Tr, PERI-Tr, MI-Tr) compared to sedentary cohorts (P<0.001). Training also resulted in similar increases in normalized LVH (LV/BW) in CONT-Tr and PERI-Tr mice. 2D-echocardiographic evaluation of LV internal chamber dimensions revealed that stroke diameter (SD) was larger in PERI compared to MI (P<0.01) but not CONT mice. Ventricular B-type natriuretic peptide mRNA (BNP) was elevated only in the 2 MI groups. Left ventricle β1-adrenergic receptor (β1-AR) and melusin transcripts both demonstrated an overall increase in trained compared to sedentary mice (both P<0.05). Additionally long-term pericardiectomy did not further enhance running performance or increase LV/BW in either sedentary or trained mice.

* Both authors contributed equally to the study