Int J Sports Med 2017; 38(04): 263-269
DOI: 10.1055/s-0042-119727
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Digoxin Induces Cardiac Hypertrophy Without Negative Effects on Cardiac Function and Physical Performance in Trained Normotensive Rats

Claodete Hasselstrom Neves
1  UFMT, Laboratório de Fisiologia - Instituto de Ciências da Saúde, Cuiabá, Brazil
,
Ramires Alsamir Tibana
2  Catholic University of Brasilia, Physical Education, Taguatinga, Brazil
,
Jonato Prestes
2  Catholic University of Brasilia, Physical Education, Taguatinga, Brazil
,
Fabricio Azevedo Voltarelli
3  UFMT, Bioscience/Nutrition, Cuiabá, Brazil
,
Andreo Fernando Aguiar
4  North University of Paraná (UNOPAR), Centre of Biological and Healthy Sciences, Londrina, Brazil
,
Gustavo Augusto Ferreira Mota
5  UFMT, Laboratório de Fisiologia - Instituto de Ciências da Saúde, Cuiabá, Brazil
,
Sergio Luiz Borges de Sousa
5  UFMT, Laboratório de Fisiologia - Instituto de Ciências da Saúde, Cuiabá, Brazil
,
Andre Soares Leopoldo
6  Universidade Federal de Espírito Santo, Laboratório de Fisiologia e Bioquímica Experimental/NUPEM, Vitoria, Brazil
,
Ana Paula Lima Leopoldo
6  Universidade Federal de Espírito Santo, Laboratório de Fisiologia e Bioquímica Experimental/NUPEM, Vitoria, Brazil
,
Andre Mueller
5  UFMT, Laboratório de Fisiologia - Instituto de Ciências da Saúde, Cuiabá, Brazil
,
Danilo Henrique Aguiar
5  UFMT, Laboratório de Fisiologia - Instituto de Ciências da Saúde, Cuiabá, Brazil
,
James Wilfred Navalta
7  University of Nevada, Las Vegas, Kinesiology and Nutrition Sciences, Las Vegas, United States
,
Mario Mateus Sugizaki
5  UFMT, Laboratório de Fisiologia - Instituto de Ciências da Saúde, Cuiabá, Brazil
› Author Affiliations
Further Information

Publication History



accepted after revision 13 October 2016

Publication Date:
20 February 2017 (online)

Abstract

Cardiotonic drugs and exercise training promote cardiac inotropic effects, which may affect training-induced cardiac adaptations. This study investigated the effects of long-term administration of digoxin on heart structure and function, and physical performance of rats submitted to high-intensity interval training (HIIT). Male Wistar rats, 60 days old, were divided into control (C), digoxin (DIGO), trained (T), and trained with digoxin (TDIGO). Digoxin was administered by gavage (30 µg/kg/day) for 75 days. The HIIT program consisted of treadmill running 60 min/day (8 min at 80% of the maximum speed (MS) and 2 min at 20% of the MS), 5 days per week during 60 days. The main cardiac parameters were evaluated by echocardiograph and cardiomyocyte area was determined by histology. There were no group x time effects of digoxin, HIIT or interactions (digoxin and HIIT) on functional echocardiographic parameters (heart rate; ejection fraction) or in the maximum exercise test. There was a group x time interaction, as evidenced by observed cardiac hypertrophy in the TDIGO group evaluated by ratio of left ventricle weight to body weight (p<0.002) and cardiomyocyte area (p<0.000002). Long-term administration of digoxin promoted cardiac hypertrophy without affecting cardiac function and physical performance in rats submitted to HIIT.