Assessment of Baseline Nutritional Status, Vitamin B12, and Folate Levels in Patients with Acute Leukemia and Their Effect on Initial Treatment Outcome: A Prospective Observational Study

Shweta Maurya; Anil Kumar Tripathi; Shailendra Prasad Verma; Wahid Ali; Saurabh Shukla

doi:10.1055/s-0042-1742665

Indian Journal of Medical and Paediatric Oncology, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2022; 43(02): 171-176
DOI: 10.1055/s-0042-1742665

Original Article

Assessment of Baseline Nutritional Status, Vitamin B12, and Folate Levels in Patients with Acute Leukemia and Their Effect on Initial Treatment Outcome: A Prospective Observational Study

Authors

Shweta Maurya

¹Department of Clinical Hematology, King George's Medical University, Chowk, Lucknow, India
Anil Kumar Tripathi

¹Department of Clinical Hematology, King George's Medical University, Chowk, Lucknow, India
Shailendra Prasad Verma

¹Department of Clinical Hematology, King George's Medical University, Chowk, Lucknow, India
Wahid Ali

²Department of Pathology, King George's Medical University, Chowk, Lucknow, India
Saurabh Shukla

¹Department of Clinical Hematology, King George's Medical University, Chowk, Lucknow, India

Abstract

Introduction Poor nutrition is a common finding in patients with acute leukemia, affecting disease progression, treatment outcome, and survival. Overall nutritional status and micronutrients status evaluation may be an important step in management of acute leukemia.

Objective The objective of this study was to investigate baseline nutritional status, vitamin B12, and folate levels in patients with acute leukemia at the time of admission before starting chemotherapy and their initial treatment outcome.

Materials and Methods This was a prospective observational study. We assessed the pretreatment nutritional status of 73 patients by body mass index (BMI), serum vitamin B12 using a two-step chemiluminescent microparticle immunoassay, and serum folate using electrochemiluminescence by Cobas e411 analyzer before initiation of induction chemotherapy and evaluated for treatment response at the end of induction chemotherapy.

Results Out of a total of 73 patients, 51 (69.8%) completed induction chemotherapy, 36 (49.3%) showed complete remission, and 15 (20.5%) were in incomplete remission. Of the remaining 22 (30.1%) patients, 11 (15.1%) died due to toxicity during therapy. The mean values of baseline BMI, serum vitamin B12, and folate was 20.46 kg/m², 956.04, and 13.52 ng/mL, respectively. There was no significant association between vitamin B12 (p-value = 0.609) and folate (p-value = 0.404) deficiency and the response to treatment.

Conclusion Baseline nutritional status, serum vitamin B12, and folate levels have no significant role in induction outcome in response to treatment, including mortality in patients with acute leukemia.

Keywords

acute leukemia - folate - induction chemotherapy - micronutrient status - vitamin B12

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