CC BY-NC-ND 4.0 · South Asian J Cancer 2022; 11(03): 229-234
DOI: 10.1055/s-0042-1743162
Original Article
Head and Neck Cancer

Maximal Thymectomy via Mini Sternotomy with Pleural Preservation

1   Department of Surgical Oncology, Bombay Hospital and Medical Research Centre, Marine Lines, Mumbai, Maharashtra, India
,
Bojja V. Kishore Reddy
1   Department of Surgical Oncology, Bombay Hospital and Medical Research Centre, Marine Lines, Mumbai, Maharashtra, India
,
Prakash Patil
1   Department of Surgical Oncology, Bombay Hospital and Medical Research Centre, Marine Lines, Mumbai, Maharashtra, India
› Author Affiliations

Abstract

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Gaurav Patel

Background There are different surgical techniques used for maximal thymectomy. Each technique has its own advantages and disadvantages. We propose a mini sternotomy with pleural preservation approach for complete maximal thymectomy.

Methods Over time range of 5 years, 32 patients with diagnosis of thymoma with or without myasthenia gravis (MG) underwent maximal thymectomy by mini sternotomy in our institute. Patient records were examined for the following parameters: age, sex, preoperative medication, symptoms of MG as per Myasthenia Gravis Foundation of America grading system, operating time, duration of postoperative ventilation, length of stay in the intensive care unit, overall length of hospitalization, and postoperative complications.

Results The mean age of patients in our study was 43.66. Sex ratio in this study was almost equal. Sixty-nine percent of patients were stage I thymoma according to Masaoka staging. Size of the tumor ranged from 3 to 8 cm with mean size being 4.54 cm. Complete resection with negative tumor margins was possible in all the cases. Four patients had intraoperative pleural injury out of which two patients required intercostal tube insertion. We did not have any serious postoperative complications with no perioperative mortality.

Conclusions Mini sternotomy allows maximal removal of thymus through a less invasive approach and is associated with a significantly smoother postoperative course, less overall complications, and good clinical outcome. It is a simple technique that can be performed by any thoracic and surgical oncologists especially in Indian subcontinent where facilities of video-assisted thoracoscopic surgery and robotic video-assisted thoracoscopic surgery are not available in all areas and are expensive.



Publication History

Article published online:
22 March 2022

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  • References

  • 1 Detterbeck FC, Parsons AM. Thymic tumors. Ann Thorac Surg 2004; 77 (05) 1860-1869
  • 2 Cowen D, Hannoun-Levi JM, Resbeut M, Alzieu C. Natural history and treatment of malignant thymoma. Oncology (Williston Park) 1998; 12 (07) 1001-1005 , discussion 1006
  • 3 Keijzers M, de Baets M, Hochstenbag M. et al. Robotic thymectomy in patients with myasthenia gravis: neurological and surgical outcomes. Eur J Cardiothorac Surg 2015; 48 (01) 40-45
  • 4 Kondo K. Therapy for thymic epithelial tumors. Gen Thorac Cardiovasc Surg 2014; 62 (08) 468-474
  • 5 Keating CP, Kong YX, Tay V, Knight SR, Clarke CP, Wright GM. VATS thymectomy for nonthymomatous myasthenia gravis: standardized outcome assessment using the myasthenia gravis foundation of America clinical classification. Innovations (Phila) 2011; 6 (02) 104-109
  • 6 Detterbeck F, Youssef S, Ruffini E, Okumura M. A review of prognostic factors in thymic malignancies. J Thorac Oncol 2011; 6 (7, Suppl 3): S1698-S1704
  • 7 Blalock A, Mason MF, Morgan HJ, Riven SS. Myasthenia gravis and tumors of the thymic region: report of a case in which the tumor was removed. Ann Surg 1939; 110 (04) 544-561
  • 8 Masaoka A, Yamakawa Y, Niwa H. et al. Extended thymectomy for myasthenia gravis patients: a 20-year review. Ann Thorac Surg 1996; 62 (03) 853-859
  • 9 Jaretzki III A, Penn AS, Younger DS. et al. “Maximal” thymectomy for myasthenia gravis. Results. J Thorac Cardiovasc Surg 1988; 95 (05) 747-757
  • 10 Nieto IP, Robledo JP, Pajuelo MC. et al. Prognostic factors for myasthenia gravis treated by thymectomy: review of 61 cases. Ann Thorac Surg 1999; 67 (06) 1568-1571
  • 11 Hatton PD, Diehl JT, Daly BD. et al. Transsternal radical thymectomy for myasthenia gravis: a 15-year review. Ann Thorac Surg 1989; 47 (06) 838-840
  • 12 Grandjean JG, Lucchi M, Mariani MA. Reversed-T upper mini-sternotomy for extended thymectomy in myasthenic patients. Ann Thorac Surg 2000; 70 (04) 1423-1424 , discussion 1425
  • 13 Kirschner PA, Osserman KE, Kark AE. Studies in myasthenia gravis. Transcervical total thymectomy. JAMA 1969; 209 (06) 906-910
  • 14 LoCicero III J. The combined cervical and partial sternotomy approach for thymectomy. Chest Surg Clin N Am 1996; 6 (01) 85-93
  • 15 Zahid I, Sharif S, Routledge T, Scarci M. Video-assisted thoracoscopic surgery or transsternal thymectomy in the treatment of myasthenia gravis?. Interact Cardiovasc Thorac Surg 2011; 12 (01) 40-46
  • 16 Raza A, Woo E. Video-assisted thoracoscopic surgery versus sternotomy in thymectomy for thymoma and myasthenia gravis. Ann Cardiothorac Surg 2016; 5 (01) 33-37
  • 17 Hess NR, Sarkaria IS, Pennathur A, Levy RM, Christie NA, Luketich JD. Minimally invasive versus open thymectomy: a systematic review of surgical techniques, patient demographics, and perioperative outcomes. Ann Cardiothorac Surg 2016; 5 (01) 1-9
  • 18 Rowse PG, Roden AC, Corl FM. et al. Minimally invasive thymectomy: the Mayo Clinic experience. Ann Cardiothorac Surg 2015; 4 (06) 519-526
  • 19 Fok M, Bashir M, Harky A. et al. Video-assisted thoracoscopic versus robotic-assisted thoracoscopic thymectomy: systematic review and meta-analysis. Innovations (Phila) 2017; 12 (04) 259-264
  • 20 Kondo K, Monden Y. Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan. Ann Thorac Surg 2003; 76 (03) 878-884 , discussion 884–885
  • 21 Kim DJ, Yang WI, Choi SS, Kim KD, Chung KY. Prognostic and clinical relevance of the World Health Organization schema for the classification of thymic epithelial tumors: a clinicopathologic study of 108 patients and literature review. Chest 2005; 127 (03) 755-761
  • 22 Rea F, Marulli G, Girardi R. et al. Long-term survival and prognostic factors in thymic epithelial tumours. Eur J Cardiothorac Surg 2004; 26 (02) 412-418
  • 23 Zhu G, He S, Fu X, Jiang G, Liu T. Radiotherapy and prognostic factors for thymoma: a retrospective study of 175 patients. Int J Radiat Oncol Biol Phys 2004; 60 (04) 1113-1119
  • 24 Nakagawa K, Asamura H, Matsuno Y. et al. Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardiovasc Surg 2003; 126 (04) 1134-1140
  • 25 Ferguson MK. Transcervical thymectomy. Semin Thorac Cardiovasc Surg 1999; 11 (01) 59-64
  • 26 Onuki T, Ishikawa S, Iguchi K. et al. Limited thymectomy for stage I or II thymomas. Lung Cancer 2010; 68 (03) 460-465
  • 27 Tseng Y-C, Hsieh C-C, Huang H-Y. et al. Is thymectomy necessary in nonmyasthenic patients with early thymoma?. J Thorac Oncol 2013; 8 (07) 952-958
  • 28 Odaka M, Akiba T, Yabe M. et al. Unilateral thoracoscopic subtotal thymectomy for the treatment of stage I and II thymoma. Eur J Cardiothorac Surg 2010; 37 (04) 824-826
  • 29 Manoly I, Whistance RN, Sreekumar R. et al. Early and mid-term outcomes of trans-sternal and video-assisted thoracoscopic surgery for thymoma. Eur J Cardiothorac Surg 2014; 45 (06) e187-e193
  • 30 He Z, Zhu Q, Wen W, Chen L, Xu H, Li H. Surgical approaches for stage I and II thymoma-associated myasthenia gravis: feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy in comparison with trans-sternal resection. J Biomed Res 2013; 27 (01) 62-70
  • 31 Kimura T, Inoue M, Kadota Y. et al. The oncological feasibility and limitations of video-assisted thoracoscopic thymectomy for early-stage thymomas. Eur J Cardiothorac Surg 2013; 44 (03) e214-e218
  • 32 Tagawa T, Yamasaki N, Tsuchiya T. et al. Thoracoscopic versus transsternal resection for early stage thymoma: long-term outcomes. Surg Today 2014; 44 (12) 2275-2280
  • 33 Cakar F, Werner P, Augustin F. et al. A comparison of outcomes after robotic open extended thymectomy for myasthenia gravis. Eur J Cardiothorac Surg 2007; 31 (03) 501-504 , discussion 504–505
  • 34 Kamel MK, Rahouma M, Stiles BM, Nasar A, Altorki NK, Port JL. Robotic thymectomy: learning curve and associated perioperative outcomes. J Laparoendosc Adv Surg Tech A 2017; 27 (07) 685-690
  • 35 Renaud S, Santelmo N, Renaud M. et al. Robotic-assisted thymectomy with Da Vinci II versus sternotomy in the surgical treatment of non-thymomatous myasthenia gravis: early results. Rev Neurol (Paris) 2013; 169 (01) 30-36
  • 36 Seong YW, Kang CH, Choi J-W. et al. Early clinical outcomes of robot-assisted surgery for anterior mediastinal mass: its superiority over a conventional sternotomy approach evaluated by propensity score matching. Eur J Cardiothorac Surg 2014; 45 (03) e68-e73 , discussion e73
  • 37 Freeman RK, Ascioti AJ, Van Woerkom JM, Vyverberg A, Robison RJ. Long-term follow-up after robotic thymectomy for nonthymomatous myasthenia gravis. Ann Thorac Surg 2011; 92 (03) 1018-1022 , discussion 1022–1023
  • 38 Şehitogullari A, Nasır A, Anbar R, Erdem K, Bilgin C. Comparison of perioperative outcomes of videothoracoscopy and robotic surgical techniques in thymoma. Asian J Surg 2020; 43 (01) 244-250
  • 39 Toker A, Erus S, Ozkan B, Ziyade S, Tanju S. Does a relationship exist between the number of thoracoscopic thymectomies performed and the learning curve for thoracoscopic resection of thymoma in patients with myasthenia gravis?. Interact Cardiovasc Thorac Surg 2011; 12 (02) 152-155
  • 40 Lucchi M, Davini F, Ricciardi R. et al. Management of pleural recurrence after curative resection of thymoma. J Thorac Cardiovasc Surg 2009; 137 (05) 1185-1189
  • 41 Maniscalco P, Tamburini N, Quarantotto F, Grossi W, Garelli E, Cavallesco G. Long-term outcome for early stage thymoma: comparison between thoracoscopic and open approaches. Thorac Cardiovasc Surg 2015; 63 (03) 201-205
  • 42 Di Crescenzo VG, Napolitano F, Panico C. et al. Surgical approach in thymectomy: our experience and review of the literature. Int J Surg Case Rep 2017; 39: 19-24