The Human Genetics of Dental Anomalies

Mahamad Irfanulla Khan; Nadeem Ahmed; Praveen Kumar Neela; Nayeem Unnisa

doi:10.1055/s-0042-1743572

Global Medical Genetics, Inhaltsverzeichnis

CC BY 4.0 · Glob Med Genet 2022; 09(02): 076-081
DOI: 10.1055/s-0042-1743572

Review Article

The Human Genetics of Dental Anomalies

Mahamad Irfanulla Khan

¹Department of Orthodontics & Dentofacial Orthopedics, The Oxford Dental College, Bangalore, Karnataka, India

,

Nadeem Ahmed

²General Dental Practitioner, Max Dental Specialties, Bangalore, Karnataka, India

,

Praveen Kumar Neela

³Department of Orthodontics & Dentofacial Orthopedics, Kamineni Institute of Dental Sciences, Narketpally, Andhra Pradesh, India

,

Nayeem Unnisa

⁴General Dental Practitioner, The Dental Clinic, Bangalore, Karnataka, India

› Institutsangaben

Abstract

The development of tooth is a highly complex procedure and mastered by specific genetic programs. Genetic alterations, environmental factors, and developmental timing can disturb the execution of these programs, and result in various dental anomalies like hypodontia/oligodontia, and supernumerary teeth, which are commonly seen in our clinical practice. Advances in molecular research enabled the identification of various genes involved in the pathogenesis of dental anomalies. In the near future, it will help provide a more accurate diagnosis and biological-based treatment for these anomalies. In this article, we present the molecular phenomenon of tooth development and the genetics of various dental anomalies.

Keywords

tooth development - dental anomalies - genetics - genes - mutations

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