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CC BY-NC-ND 4.0 · Arch Plast Surg 2022; 49(03): 405-412
DOI: 10.1055/s-0042-1744423
Pediatric/Craniomaxillofacial/Head & Neck
Case Report

Therapeutic Effect of Autologous Activated Platelet-rich Plasma Therapy on Mid-dermal to Full-thickness Burns: A Case Series

Karina Karina
1   Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta Pusat, Indonesia
2   HayandraLab, Yayasan Hayandra Peduli, Jakarta Pusat, Indonesia
3   Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Indonesia
4   Pusat Kajian Stem Cell, Universitas Pembangunan Nasional Veteran Jakarta, Indonesia
,
Krista Ekaputri
1   Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta Pusat, Indonesia
,
Johannes Albert Biben
1   Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta Pusat, Indonesia
,
Pritha Hadi
5   Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia
6   Raden Mattaher Regional Hospital, Jambi, Indonesia
,
Hubert Andrew
2   HayandraLab, Yayasan Hayandra Peduli, Jakarta Pusat, Indonesia
7   Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia
,
Patricia Marcellina Sadikin
1   Klinik Hayandra, Yayasan Hayandra Peduli, Jakarta Pusat, Indonesia
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Abstract

Although modern medicine has made great strides in the management of burn injuries, associated complications such as pain, infection, dyspigmentation, and scarring have yet to be fully dealt with. Although skin grafting and meshing are routinely performed on burn patients, this method poses a risk for adverse effects. Activated autologous platelet-rich plasma (aaPRP), which is increasingly used in the field of plastic surgery, contains growth factors beneficial for wound regeneration. Seven cases of burns with varying severity and conditions that were treated with intralesional subcutaneous injection and intravenous aaPRP are presented and discussed herein. This case series indicates that subcutaneous and intravenous aaPRP is a safe procedure with the potential to be an alternative when skin grafting cannot be done or as an adjunct treatment to skin grafting.

Keywords

platelet-rich plasma - burns - skin transplantation

Author Contributions

Conceptualization: K.K. Investigation: K.E., J.A.B., and P.H. Resources: K.K. Writing–original draft: K.K., K. E., J.A.B., P.H., H.A., and P.M.S. Writing–review and editing: K.K., K.E., J.A.B., P.H., and H.A.


Ethical Approval

This study was approved by the Health Research Ethics Committee, University of Indonesia, and Cipto Mangunkusumo Hospital (No. 0249/UN2.F1/ETIK/2018) and performed in accordance with the principles of the Declaration of Helsinki.


Patient Consent

Informed consent was obtained from the patients.




Publication History

Article published online:
27 May 2022

© 2022. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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