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DOI: 10.1055/s-0042-1746452
Antimicrobial prophylaxis with Clindamycin in clean-contaminated head and neck surgery elevates the rate of surgical site infections in tracheostomies – A retrospective monocentric comparative study
Authors
Backround Surgical site infection (SSI) in open surgical tracheostomy (ST) occurs in up to 33% of the cases. SSI can be reduced by a postoperative antibiotic prophylaxis (POAP). The effect of Clindamycin on SSIs in head and neck surgery (HNS) is discussed controversially in literature.
Methods A 8-year single-center retrospective comparative analysis of 441 STs (Visor-ST and Bjoerk-flap technique) performed within major HNS were evaluated due to the event of a SSI within 7 days and analyzed descriptively. Logistic regression model evaluated the impact of POAP with Clindamycin on SSIs.
Results The use of Clindamycin showed twice the rate of ST-SSI as all patients that did not receive Clindamycin, treated with other perioperative antibiotics. (Fisher’s p=0.008) The logistic regression model couldn’t proof a statistical significant impact. (OR=2.91, p=0.04)
Conclusion We recommend Clindamycin should be reconsidered as a POAP regimen in ST. Further studies should evaluate alternatives like Cephalosporines for Penicillin-allergic patients.
Publication History
Article published online:
24 May 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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