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DOI: 10.1055/s-0042-1746796
Volumetric MRI analysis of the auditory pathway in single-sided deafness – a retrospective study
Purpose
Recently, cochlear implant (CI) was established as a treatment for single-sided deafness (SSD) in adults and children. In SSD, a progressive functional asymmetry of the auditory pathway was observed. We investigated the volume of the primary auditory cortex and regions with known cross-modal plasticity (visual cortex, somatosensory cortex) in SSD to assess potential biomarkers for the outcome and success of CI surgery.
Methods
Retrospectively, we compared preoperative MRI data (n=135) of children and adults with SSD with an age- and gender-matched group of bilaterally deaf patients. For the adult group, in addition, we compared the results with patients who had a short history of deafness (i.e., sudden hearing loss). Grey matter tissue probabilty values as derived by CAT 12 were read out using a probablistic atlas approach (AAL3) and were smoothed with 9 mm FWHM for the primary auditory cortex, and visual and somatosensory cortex. Regional grey matter values were compared between patients with SSD and bilateral deafnesspatients, taking the side of deafness in SSD into account.
Results
Our preliminary results showed different volumetric left-right side differences of the auditory pathway for children and adults with SSD compared to an age- and gender-matched bilaterally deaf group and SSD group with short history of deafness (adults). Children with SSD displayed a significant asymmetry in GM regional volume for superior temporal gyrus compared to bilateral deaf patients (p=0.039).
Conclusion
Our data point to that there is a reduction in volume of the associated auditory cortex in pediatric SSD. Prospective data and further analysis are needed to draw conclusions about outcome.
Conflict of InterestDer Erstautor weist auf folgenden Interessenkonflikt hinRauch AK – MED-EL, Innsbruck, Österreich: reimbursement of travel expenses.Arndt S – Cochlear Ltd., Lane Cove, Australia: research funding, reimbursement of travel expenses; MED-EL, Innsbruck, Österreich: research funding, reimbursement of travel expenses; Advanced Bionics, Stäfa, Schweiz: research funding, reimbursement of travel expenses; Oticon Medical A/S, Smørum, Dänemark: research funding, reimbursement of travel expenses.
Publikationsverlauf
Artikel online veröffentlicht:
24. Mai 2022
© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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