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CC BY 4.0 · Chinese medicine and natural products 2022; 02(01): e28-e31
DOI: 10.1055/s-0042-1747915
Original Article

COVID-19 Resulting in Potential Hearing Damage of Rodents

Authors

  • Jinxin Miao

    1   Academy of Chinese Medicine Science, Henan University of Chinese Medicine, Zhengzhou, Henan, China
    2   National Center for International Research in Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China

  • Hongen Xu

    3   Precision Medicine Center of Zhengzhou University, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China
    4   Precision Medicine Center of Zhengzhou University, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

  • Yongan Tian

    5   BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China

  • Jianyao Wang

    2   National Center for International Research in Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China

  • Wenxue Tang

    3   Precision Medicine Center of Zhengzhou University, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China
    4   Precision Medicine Center of Zhengzhou University, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

  • Yaohe Wang

    2   National Center for International Research in Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China
    6   Centre for Biomarkers & Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

  • Mingsan Miao

    1   Academy of Chinese Medicine Science, Henan University of Chinese Medicine, Zhengzhou, Henan, China

  • Jianbo Liu

    4   Precision Medicine Center of Zhengzhou University, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

  • Xia Xue

    2   National Center for International Research in Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China
    3   Precision Medicine Center of Zhengzhou University, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China

  • Yongjun Guo

    7   Henan Academy of Medical Sciences, Zhengzhou, Henan, China
    8   Henan Tumor Hospital, Zhengzhou University, Zhengzhou, Henan, China

Funding This study was supported by the Department of Science and Technology of Henan Province (201100312100) and Collaborative Innovation Project of Zhengzhou (Zhengzhou University) (18XTZX12004), Scientific Research Project of Epidemic Prevention and Control in Henan (211100310900), Postdoctoral Research Startup Project in Henan Province (202001043).
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Abstract

Objectives To find out the association between the sensorineural hearing loss and coronavirus disease 2019 (COVID-19), the expression of ACE2 and TMPRSS2 in hamsters and mice was detected.

Design Using the public data from the National Center for Biotechnology Information and the Global Initiative on Sharing All Influenza Data, the expression of ACE2 and TMPRSS2 at the transcriptomic, DNA, and protein levels of ACE2 in the brain, inner ear, and muscle from the golden Syrian hamsters (Mesocricetus auratus) and mice (Mus musculus) was assessed.

Results We identified ACE2 and TMPRSS2 expressed at different levels in the inner ear and brain at DNA and transcriptomic levels of both mice and hamsters. The protein expression from the brain and inner ear showed a similar pattern, while the expression of ACE2 from the inner ear was relatively higher than that from the muscle.

Conclusion Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shows genetic potential to infect the hearing system of rodents and lead to sudden sensorineural hearing loss that can be used as a characteristic to detect asymptomatic patients of COVID-19.

Keywords

sudden sensorineural hearing loss - COVID-19 - animal models - inner ear

Credit Autorship Contribution Statement

Xue Xia, Xu Hongen and Jinxin Miao: Carrying out the experiments. Xue Xia: Analysis and interpretation of data, and writing-original draft. Mingsan Miao and Yaohe Wang: Finishing the qRT-PCR and Western blot. Wenxue Tang, Jinxin Miao and Jianyao Wang: Revising the manuscript.




Publikationsverlauf

Eingereicht: 24. Oktober 2021

Angenommen: 23. Januar 2022

Artikel online veröffentlicht:
07. Juli 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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