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DOI: 10.1055/s-0042-1749424
Utility of Serum Uric Acid to High-Density Lipoprotein Ratio in Prediction of Glycemic Control
Autoren
Abstract
Introduction India has witnessed diabetes as a growing problem and is on the verge of a diabetes mellitus (DM) epidemic. Glycemic control is the way to prevent the morbidity associated with diabetes. This study aimed to find out the utility of uric acid to the high-density lipoprotein (HDL) ratio (UHR) as a marker of diabetic control.
Methodology A hospital-based cross-sectional study was conducted among type-2 diabetic individuals who attended outpatient clinics and individuals who admitted to the inpatient wards of our hospital were enlisted. HDL cholesterol, serum uric acid, glycated hemoglobin were performed. Hemoglobin A1c (HbA1c) lower than 7% was classified as a good-controlled type-2 (DM) group and those with HbA1c between 7 and 10% were classified as uncontrolled type-2 DM group and those with HbA1c greater than 10% were classified as poorly controlled type-2 DM group. HbA1c was correlated with HDL, serum uric acid, and UHR.
Results Our study demonstrates that uric acid is inversely related to HbA1c and uric acid decreases following elevated HbA1c, and this relationship was statistically significant, whereas there was a nonsignificant inverse relationship between HDL and HbA1c and UHR with HbA1c.
Conclusion Established diabetics will have a lowering of uric acid as the diabetic control worsens and UHR could not be used as a marker of diabetic control.
Keywords
diabetes mellitus - uric acid to high-density lipoprotein ratio - serum uric acid - high-density lipoproteinPublikationsverlauf
Artikel online veröffentlicht:
09. Juni 2022
© 2022. Nitte (Deemed to be University). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 2018; 14 (02) 88-98
- 2 Malek R, Hannat S, Nechadi A, Mekideche FZ, Kaabeche M. Diabetes and Ramadan: a multicenter study in Algerian population. Diabetes Res Clin Pract 2019; 150: 322-330
- 3 Gilstrap LG, Chernew ME, Nguyen CA. et al. Association between clinical practice group adherence to quality measures and adverse outcomes among adult patients with diabetes. JAMA Netw Open 2019; 2 (08) e199139
- 4 Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomark Insights 2016; 11: 95-104
- 5 Kocak MZ, Aktas G, Erkus E, Sincer I, Atak B, Duman T. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras (1992) 2019; 65 (01) 9-15
- 6 Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K. Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. Eur J Epidemiol 2003; 18 (06) 523-530
- 7 Choi HK, Ford ES. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med 2007; 120 (05) 442-447
- 8 Krishnan E, Pandya BJ, Chung L, Hariri A, Dabbous O. Hyperuricemia in young adults and risk of insulin resistance, prediabetes, and diabetes: a 15-year follow-up study. Am J Epidemiol 2012; 176 (02) 108-116
- 9 Yadav D, Lee ES, Kim HM. et al. Prospective study of serum uric acid levels and incident metabolic syndrome in a Korean rural cohort. Atherosclerosis 2015; 241 (01) 271-277
- 10 Cook DG, Shaper AG, Thelle DS, Whitehead TP. Serum uric acid, serum glucose and diabetes: relationships in a population study. Postgrad Med J 1986; 62 (733) 1001-1006
- 11 Wei F, Chang B, Yang X, Wang Y, Chen L, Li WD. Serum uric acid levels were dynamically coupled with hemoglobin A1c in the development of type 2 diabetes. Sci Rep 2016; 6 (01) 28549
- 12 Choi HK, Ford ES. Haemoglobin A1c, fasting glucose, serum C-peptide and insulin resistance in relation to serum uric acid levels–the Third National Health and Nutrition Examination Survey. Rheumatology (Oxford) 2008; 47 (05) 713-717
- 13 Enomoto A, Kimura H, Chairoungdua A. et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002; 417 (6887): 447-452
- 14 Nan H, Dong Y, Gao W, Tuomilehto J, Qiao Q. Diabetes associated with a low serum uric acid level in a general Chinese population. Diabetes Res Clin Pract 2007; 76 (01) 68-74
- 15 Cui Y, Bu H, Ma X, Zhao S, Li X, Lu S. The relation between serum uric acid and HbA1c is dependent upon hyperinsulinemia in patients with newly diagnosed type 2 diabetes mellitus. J Diabetes Res 2016; 2016: 7184123
- 16 D'Agostino Sr RB, Vasan RS, Pencina MJ. et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008; 117 (06) 743-753
- 17 Femlak M, Gluba-Brzózka A, Ciałkowska-Rysz A, Rysz J. The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk. Lipids Health Dis 2017; 16 (01) 207
- 18 Klisic A, Kavaric N, Jovanovic M. et al. Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus. J Res Med Sci 2017; 22 (01) 122
- 19 Awadalla H, Noor SK, Elmadhoun WM. et al. Comparison of serum lipid profile in type 2 diabetes with and without adequate diabetes control in Sudanese population in north of Sudan. Diabetes Metab Syndr 2018; 12 (06) 961-964