Tierarztl Prax Ausg G Grosstiere Nutztiere 2022; 50(03): 209
DOI: 10.1055/s-0042-1749959
Abstract
Vorträge

Histopathological characteristics, subtypes, and prognostic features in 107 cats with immune-mediated polyneuropathy

N Kolb
1   Section of Clinical & Comparative Neuropathology, LMU Munich, Germany
,
K Matiasek
1   Section of Clinical & Comparative Neuropathology, LMU Munich, Germany
,
J van Renen
2   Clinic for Small Animal Medicine, Center for Clinical Veterinary Medicine, LMU Munich, Germany
,
A Fischer
2   Clinic for Small Animal Medicine, Center for Clinical Veterinary Medicine, LMU Munich, Germany
,
Y Zablotski
2   Clinic for Small Animal Medicine, Center for Clinical Veterinary Medicine, LMU Munich, Germany
,
J Nessler
3   Clinic for Small Animals, University of Veterinary Medicine Hannover (Foundation), Hannover, Germany
,
R Cappello
4   North Downs Specialist Referrals, Bletchingley, UK
,
T Flegel
5   Small Animal Clinic, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany
,
S Loderstedt
5   Small Animal Clinic, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany
,
K Gnirs
6   Section of Neurology & Neurosurgery, Advetia Clinic for Small Animal Medicine, Paris, France
,
K Rentmeister
7   Tierärztliche Praxis für Neurologie, Dettelbach, Germany
,
S Rupp
8   Small Animal Hospital, Tierklinik Hofheim, Hofheim, Germany;
,
F Steffen
9   Section of Neurology/Neurosurgery, Vetsuisse Faculty of the University of Zurich, Zurich, Switzerland
,
K Jurina
10   Small Animal Hospital, Tierklinik Haar, Haar, Germany
,
O Del Vecchio
11   Centro Veterinario Caleidos, Albisola Superiore, Italy
,
M Deutschland
12   Neurologische Überweisungspraxis für Haustiere, Berlin, Germany
,
F König
13   Tierarztpraxis Dr. Florian König, Wiesbaden, Germany
,
T Gagliardo
14   Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
,
G Gandini
14   Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
,
T Harcourt-Brown
15   Neurology, Langford Veterinary Services, Langford, UK
,
M Kornberg
16   Small Animal Clinic Trier, Germany
,
E Bianchi
17   Department of Veterinary Science, University of Parma, Parma, Italy
,
M Menchetti
18   Clinica Veterinaria San Marco, Veggiano, Italy
,
H Schenk
19   Neurology Service, Tierklinik Lueneburg, Lueneburg, Germany
,
J Tabanez
20   Fitzpatrick Referrals, Godalming, UK
,
M Rosati
1   Section of Clinical & Comparative Neuropathology, LMU Munich, Germany
› Author Affiliations
 

Introduction Immune-mediated polyneuropathy (IMPN) is the most common cause of lower motor neuron disease in cats. As clinical presentation does not constantly appear to predict outcome and risk of relapses, this study was performed to identify prognostic morphological parameters in a large cohort of cats.

Material and Methods Nerve and muscle biopsies of 107 cats histologically diagnosed with inflammatory polyneuropathy and 22 control animals were evaluated for a set of 36 histological parameters. To identify different morphological patterns, hierarchical k-means clustering was performed. Clinical data were collected using an online survey to perform a multivariate analysis correlating them with morphological variables.

Findings Clustering revealed 4 groups: 3 represented different histological patterns and the remaining comprised control cats. The multivariate model showed that active inflammatory infiltration of nerve fibres, demyelination, and loss of myelinated nerve fibers in terminal nerve branches were associated with recovery.

Conclusion Muscle and nerve biopsies identified features that were positively or negatively correlated with outcome. Not all of them were expected. Further studies are needed to investigate their significance in relation to different treatment protocols.



Publication History

Article published online:
07 July 2022

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