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Histopathological characteristics, subtypes, and prognostic features in 107 cats with immune-mediated polyneuropathy
Introduction Immune-mediated polyneuropathy (IMPN) is the most common cause of lower motor neuron disease in cats. As clinical presentation does not constantly appear to predict outcome and risk of relapses, this study was performed to identify prognostic morphological parameters in a large cohort of cats.
Material and Methods Nerve and muscle biopsies of 107 cats histologically diagnosed with inflammatory polyneuropathy and 22 control animals were evaluated for a set of 36 histological parameters. To identify different morphological patterns, hierarchical k-means clustering was performed. Clinical data were collected using an online survey to perform a multivariate analysis correlating them with morphological variables.
Findings Clustering revealed 4 groups: 3 represented different histological patterns and the remaining comprised control cats. The multivariate model showed that active inflammatory infiltration of nerve fibres, demyelination, and loss of myelinated nerve fibers in terminal nerve branches were associated with recovery.
Conclusion Muscle and nerve biopsies identified features that were positively or negatively correlated with outcome. Not all of them were expected. Further studies are needed to investigate their significance in relation to different treatment protocols.
Article published online:
07 July 2022
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