Subscribe to RSS
DOI: 10.1055/s-0042-1750072
Vancomycin-Induced Maturation Arrest with Reactive Promyelocyte Proliferation: A Diagnostic and Therapeutic Challenge
Abstract
Drug-induced leukopenia is a diagnostic and therapeutic challenge. A detailed clinical history is a must to come to a right diagnosis. Certain drugs are known to cause bone marrow suppression, leukopenia, myeloid maturation arrest, and reactive promyelocyte proliferation. Here, we report an unusual case of vancomycin-induced maturation arrest with marked promyelocyte proliferation in a 47-year-old male patient who was being treated for novel coronavirus disease 2019 (COVID-19) infection. Most times, this reactive promyelocyte proliferation is confused with neoplastic promyelocytes, leading to incorrect diagnosis and management.
Publication History
Article published online:
26 July 2022
© 2022. The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Arya TV, Prasad RN. Fatal pancytopenia in falciparum malaria. J Assoc Physicians India 1989; 37 (07) 469-470
- 2 Zvulunov A, Tamary H, Gal N. Pancytopenia resulting from hemophagocytosis in malaria. Pediatr Infect Dis J 2002; 21 (11) 1086-1087
- 3 Hatton CS, Peto TE, Bunch C. et al. Frequency of severe neutropenia associated with amodiaquine prophylaxis against malaria. Lancet 1986; 1 (8478): 411-414
- 4 Pipek R, Vulfsons S, Wolfovitz E, Har-Shai Y, Taran A, Peled IJ. Case report: ofloxacin-induced hypersensitivity vasculitis. Am J Med Sci 1996; 311 (02) 82-83
- 5 Nepali N, Kalam A, Subish P. et al. Hemoglobinurea due to ofloxacin in a 9 year old child - a case report. Pharmacologyonline 2007; 1: 1-5
- 6 Deng JY, Tovar JM. Pancytopenia with levofloxacin therapy for pelvic inflammatory disease in an otherwise healthy young patient. Ann Pharmacother 2006; 40 (09) 1692-1693
- 7 Dutta TK, Badhe BA. Ciprofloxacin-induced bone marrow depression. Postgrad Med J 1999; 75 (887) 571-573
- 8 Mitropoulos FA, Angood PB, Rabinovici R. Trovafloxacin-associated leukopenia. Ann Pharmacother 2001; 35 (01) 41-44
- 9 Chang CM, Lee NY, Lee HC. et al. Moxifloxacin-associated neutropenia in a cirrhotic elderly woman with lower extremity cellulitis. Ann Pharmacother 2008; 42 (04) 580-583
- 10 Naranjo CA, Busto U, Sellers EM. et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30 (02) 239-245
- 11 Cunha BA, Quintiliani R, Deglin JM, Izard MW, Nightingale CH. Pharmacokinetics of vancomycin in anuria. Rev Infect Dis 1981; 3 (suppl): S269-S272
- 12 Pai MP, Mercier RC, Koster SA. Epidemiology of vancomycin-induced neutropenia in patients receiving home intravenous infusion therapy. Ann Pharmacother 2006; 40 (02) 224-228
- 13 Dangerfield HG, Hewitt WL, Monzon OT. et al. Clinical use of vancomycin. Antimicrobial Agents Annual 1960; 26-28
- 14 Farber BF, Moellering Jr RC. Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981. Antimicrob Agents Chemother 1983; 23 (01) 138-141
- 15 Black E, Lau TT, Ensom MH. Vancomycin-induced neutropenia: is it dose- or duration-related?. Ann Pharmacother 2011; 45 (05) 629-638
- 16 Kauffman CA, Severance PJ, Silva Jr J, Huard TK. Neutropenia associated with vancomycin therapy. South Med J 1982; 75 (09) 1131-1133