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CC BY 4.0 · Chinese medicine and natural products 2022; 02(02): e89-e95
DOI: 10.1055/s-0042-1750322
Original Article

Meta-analysis of TCM in the Treatment of AIDS Diarrhea

Shaotian Wu
1   The first Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou Henan, China
,
Liran Xu
2   Zhang Zhongjing Research Institute, Henan University of Chinese Medicine, Zhengzhou Henan, China
,
Feng Sang
3   AIDS Virus Laboratory, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou Henan, China
,
Liangping Li
4   Department of Postgraduate, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou Henan, China
,
Yaya Guo
1   The first Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou Henan, China
› Author Affiliations Funding The study was funded by National Natural Science Foundation of China (U1604287), National Science and Technology Major Project During the “13th Five-Year” Plan Period (2017ZX10205502).
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Abstract

Objective The aim of the study is to systematically evaluate the effect of Traditional Chinese medicine (TCM) in the treatment of AIDS diarrhea.

Methods The computer system was used to comprehensively search database of Wanfang (WF), VIP, and China National Knowledge Infrastructure (CNKI) for relevant literature on the application effect of Chinese medicine in the treatment of AIDS diarrhea. The retrieval time was set from January 1, 2010 to August 15, 2021. The documents that did not meet the inclusion criteria were eliminated, and the quality of the qualified literature was evaluated according to the improved Jadad scoring standard. The main outcome indicators were entered into the literature, and Review Manager 5.0 software was used for meta-analysis.

Results Eight eligible articles were included, a total of 536 cases of AIDS diarrhea patients were included. All eight eligible articles observed the clinical efficacy of TCM in the treatment of AIDS diarrhea, among which four observed the TCM syndrome changes in the treatment of AIDS diarrhea, and four observed adverse reactions of TCM in the treatment of AIDS diarrhea. All articles were extracted for valid data. After entering all the main observation index data, the results of meta-analysis showed that the effect of TCM in the treatment of AIDS diarrhea was better, the difference was statistically significant [MD = 2.92, 95% CI (1.81, 4.70), p <0.001]; TCM in the treatment of AIDS diarrhea was more conducive to improving the TCM syndrome scores of patients, the difference was statistically significant [MD = −2.55, 95% CI (−3.37, −1.73), p< 0.001]; the adverse effects of TCM in the treatment of AIDS diarrhea were mild, and the difference was statistically significant [MD = 1.70, 95% CI (0.48, 5.97), p = 0.41].

Conclusion The effect of TCM in the treatment of AIDS diarrhea patients is remarkable, which can effectively improve the TCM symptom scores of patients without increasing the incidence of adverse reactions.

Keywords

AIDS diarrhea - TCM - syndrome score - adverse reaction - Meta-analysis

Credit Authorship Contribution Statement

Shaotian Wu: Conceptualization, data curation, formal analysis, and writing—original draft. Liran Xu: Conceptualization, methodology, funding acquisition, and writing—review & editing. Feng Sang: data curation, formal analysis, writing—review & editing. Liangping Li: data curation, software, writing—review & editing. Yaya Guo: data curation, writing—review & editing.




Publication History

Article published online:
22 August 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Colebunders R, Lusakumuni K, Nelson AM. et al. Persistent diarrhoea in Zairian AIDS patients: an endoscopic and histological study. Gut 1988; 29 (12) 1687-1691
    CrossrefPubMedSearch in Google Scholar
  • 2 Ni L, Li X, Wang Y. et al. Analysis of influencing factors on AIDS related chronic diarrhea treated by Chinese medicine. Intern J Vir 2019; 26 (01) 10-13
    Search in Google Scholar
  • 3 Yang XX, Yu JZ, Li CF. et al. Effect of YHFSP on levels of GAS, MOT and SS in patients with HIV infection-related diarrhea. Zhonghua Zhongyiyao Xuekan 2017; 35 (09) 2382-2384
    Search in Google Scholar
  • 4 Shi ZZ. Effects of ginger-moxibustion combined with dialectical diet on gastrointestinal function in patients with AIDS and diarrhea. Nurs Res China 2018; 32 (11) 1711-1715
    Search in Google Scholar
  • 5 Ma J, Liu Y, Zhong LP. et al. Comparison between Jadad scale and Cochrane collaboration's tool for assessing risk of bias on the quality and risk of bias evaluation in randomized controlled trials. China J Oral Maxillofac Surg 2012; 10 (05) 417-422
    Search in Google Scholar
  • 6 Li Z, Yuan J, Zhang XW. et al. Treatment of 19 cases of AIDS related diarrhea, spleen kidney yang deficiency syndrome with Jianpi Zhixie Fang. Stud Social Chin Charact 2016; 29 (08) 11-13
    Search in Google Scholar
  • 7 Li JR, Ma JP, Ma XL. et al. Clinical observation of moxibustion treatment for AIDS related diarrhea with spleen and stomach weakness syndrome. Mod Tradit Chin Med Mater Med World Sci Technol 2016; 18 (02) 237-240
    Search in Google Scholar
  • 8 Yang XP, Sun ZZ. Effect of Xie Li Kang Capsule on intestinal microflora of AIDS related chronic diarrhea. Tradit Chin Med Res 2018; 31 (01) 16-19
    Search in Google Scholar
  • 9 Wen B, Li XJ, Liu ZW. et al. Exploration on influence of Shenling Fuzheng capsule on patients with AIDS/HIV and chronic diarrhea after HAART based on theory of “winter disease cured in summer”. Liaoning J Tradit Chin Med 2016; 43 (11) 2302-2304
    Search in Google Scholar
  • 10 Jiao M, Zhang X, Zeng CJ. et al. Clinical research of Chinese herbal medicine package hot compress on AIDS refractory diarrhea. Pract Clin J Integr Tradit Chin West Med 2021; 21 (11) 80-81
    Search in Google Scholar
  • 11 Tian M, Ni L, Wan G. et al. Efficacy and safety of jianpi Zhixie Granule on chronic diarrhea of AIDS patients. World Chin Med 2011; 6 (03) 193-195
    Search in Google Scholar
  • 12 Yang L, Mei XL, Guo SM. 41 cases of AIDS related diarrhea treated by Huo Pu Xia Ling decoction combined with water acupuncture point injection. Tradit Chin Med Res 2013; 26 (05) 41-44
    Search in Google Scholar
  • 13 Ren M. Efficacy of the Jianpi Zhixie recipe in treating AIDS-related chronic diarrhea. Clin J Chin Med 2013; 5 (10) 103 , 106
    Search in Google Scholar
  • 14 Zhang X, Guo H, Li Z, Xu L, Zhang A, Ji A. Effectiveness of Xielikang capsules in treating HIV-related diarrhea by increasing the plasma concentration of interleukin-17. J Tradit Chin Med 2017; 37 (05) 616-620
    CrossrefPubMedSearch in Google Scholar
  • 15 Wang J, Liang BY. Research comment on the treatment of AIDS related diarrhea by traditional Chinese medicine. Zhonghua Zhongyiyao Zazhi 2017; 32 (01) 104-106
    Search in Google Scholar
  • 16 Miao H, Chen XR. The research progress of AIDS related diarrhea treated with traditional Chinese medicine. Chin J AIDS &amp. STD 2014; 20 (06) 466-468
    Search in Google Scholar
  • 17 Li XL, Wu CJ, Yin YH. et al. Application of huopu xialing decoction on therapy of “Shiqu regu”. Liaoning J Tradit Chin Med 2018; 45 (11) 2289-2291
    Search in Google Scholar
  • 18 Cao JQ, Zhang YM, Li YF. et al. Effect of herbal hot compress based on midnight-noon ebb-flow on constipation in patients with stroke. Shandong J Tradit Chin Med 2019; 38 (09) 839-842
    Search in Google Scholar
  • 19 Zhang YP, Liu ZW, Li X. et al. Clinical study of traditional Chinese medicine hot compress under the guidance of meridian flow in the treatment of constipation after stroke. Liaoning J Tradit Chin Med 2018; 45 (01) 212-213
    Search in Google Scholar
  • 20 Su QJ, Liang BY, Liu ZW. et al. Impact of two Chinese medicine preparations on efficacy of highly active antiretroviral therapy: a cross-sectional study. Chin J AIDS STD 2017; 23 (03) 199-202
    Search in Google Scholar
  • 21 Arakaki L, Tollefson D, Kharono B, Drain PK. Prevalence of rotavirus among older children and adults with diarrhea: a systematic review and meta-analysis. Vaccine 2021; 39 (33) 4577-4590
    CrossrefPubMedSearch in Google Scholar
  • 22 Hu S, Dan W, Liu J. et al. The use of traditional Chinese medicine in relieving EGFR-TKI-associated diarrhea based on network pharmacology and data mining. Evid Based Complement Alternat Med 2021; 2021: 5530898
    PubMedSearch in Google Scholar