Homeopathy
DOI: 10.1055/s-0042-1750799
Original Research Article

Individualized Homeopathic Medicines in the Treatment of Tinea Corporis: Double-Blind, Randomized, Placebo-Controlled Trial

1   Department of Materia Medica, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
,
1   Department of Materia Medica, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
,
1   Department of Materia Medica, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
,
1   Department of Materia Medica, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
,
1   Department of Materia Medica, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
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2   Department of Homoeopathy Pharmacy, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
,
1   Department of Materia Medica, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
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3   Department of Organon of Medicine and Homoeopathic Philosophy, National Institute of Homoeopathy, Salt Lake, Kolkata, West Bengal, India
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4   Department of Repertory, The Calcutta Homoeopathic Medical College and Hospital, affiliated to The West Bengal University of Health Sciences, Govt. of West Bengal, India
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5   Department of Health & Family Welfare, East Bishnupur State Homoeopathic Dispensary, Chandi Daulatabad Block Primary Health Centre, Govt. of West Bengal, West Bengal, India
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6   Department of Repertory, D.N.De Homoeopathic Medical College and Hospital, Govt. of West Bengal, Tangra, Kolkata, West Bengal, India
› Author Affiliations

Abstract

Introduction Tinea corporis (TC; ringworm or dermatophytosis) is a superficial skin infection caused by Microsporum, Epidermophyton and Trichophyton genera of dermatophytes. We compared the effects of individualized homeopathic medicines (IHMs) in fifty-millesimal (LM) potencies against placebo in TC.

Methods A double-blind, randomized, placebo-controlled, two parallel arms trial was conducted on 62 individuals suffering from TC at the National Institute of Homoeopathy, India. Participants were randomized in a 1:1 ratio to receive either IHMs in LM potencies or identical-looking placebos for a period of 3 months. The primary outcome measure was the number of participants showing complete disappearance of skin lesions after 3 months. Secondary outcomes were a numeric rating scale (NRS) measuring intensity of itching and the Skindex-29 questionnaire (overall, and three sub-scales—degree of symptoms, psychological functioning, emotional status). All were assessed at baseline and every month, up to 3 months. The intention-to-treat sample was analyzed to detect inter-group differences using two-way repeated measures analysis of variance after adjusting for baseline differences.

Results The primary outcome revealed no improvement in either of the groups (χ 2 = 0.012, p = 0.999). Inter-group differences in some of the secondary outcomes favored IHMs against placebo—itching NRS (mean group difference after 3 months: −0.7 (95% confidence interval [CI], −1.1 to −0.4; p = 0.001); Skindex-29 overall (mean group difference after 3 months: 3.2 [95% CI, −0.6 to 7.0; p = 0.009]), Skindex-29 degree of symptoms (mean group difference after 3 months: 0.9 [95% CI, −0.2 to 1.9; p = 0.007]); and Skindex-29 psychological functioning (mean group difference after 3 months: 1.7 [95% CI, 0–3.4; p = 0.002]).

Conclusion Results were negative on the primary outcome; however, secondary outcomes included some statistically significant results favoring IHMs against placebo after 3 months.

Trial registration CTRI/2019/11/021999; UTN: U1111–1242–0070.

Authors' Contributions

B.L., S.P., A.C. and N.K.S. contributed toward concept, literature search, and preparation of the article; B.L., S.P., A.C., A.K., D.B., P.B., S.D., and S.P. contributed toward the clinical study and data acquisition; M.K. and S.S. developed the concept and did the study design, data interpretation, statistical analysis, and preparation of the article. All the authors reviewed and approved the final article.


Author Disclosure Statement

None declared.


Supplementary Material



Publication History

Received: 04 November 2021

Accepted: 16 March 2022

Article published online:
19 September 2022

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