J Neurol Surg A Cent Eur Neurosurg 2023; 84(03): 275-280
DOI: 10.1055/s-0042-1753549
Review Article

Deep Brain Stimulation during Pregnancy and Delivery: Review of Current Literature

Marek Baláž
1   1st Department of Neurology, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Jiří Búřil
1   1st Department of Neurology, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Jonáš Kunst
1   1st Department of Neurology, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Dušan Hrabovský
2   Department of Neurosurgery, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic
Šimon Hajda
3   Universitätsklinik der Paracelsus Medizinischen Privatuniversität Klinikum Nürnberg - Klinik für Frauenheilkunde und Geburtshilfe, Schwerpunkt Geburtshilfe, Nürnberg, Germany
Jan Chrastina
2   Department of Neurosurgery, St. Anne's University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic
› Author Affiliations
Funding This work was supported by project PRESEnCE AZV NV 19-04-00343, Agentura Pro Zdravotnický Výzkum České Republiky.


Deep brain stimulation (DBS) is an established method in the treatment of not only Parkinson's disease motor complications but also dystonia and tremor, and there are data supporting the efficacy of DBS in epilepsy and some psychiatric problems. The alleviation of the neurologic problems may enable females of childbearing age to consider pregnancy because of being able to take care of their child. The aim of the study is to provide a review of the data available on the effect of DBS on the course of pregnancy and delivery in patients suffering from diseases amenable for DBS treatment (Parkinson's disease, dystonia, obsessive compulsive disorder, Tourette's syndrome, epilepsy). Although data available in the literature on pregnancy and childbirth in patients with an implanted active DBS system are limited to small case series and case reports, the number of younger patients implanted with DBS systems will potentially require more attention beyond specialized DBS centers. In emergency deliveries, general obstetricians and neurosurgeons should be provided with a protocol to prevent injuries to the implanted system with potentially devastating consequences for the patient.

Publication History

Received: 09 December 2021

Accepted: 23 March 2022

Article published online:
19 October 2022

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  • References

  • 1 Benabid AL, Pollak P, Louveau A, Henry S, de Rougemont J. Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 1987; 50 (1–6): 344-346
  • 2 Benabid AL, Pollak P, Gross C. et al. Acute and long-term effects of subthalamic nucleus stimulation in Parkinson's disease. Stereotact Funct Neurosurg 1994; 62 (1–4): 76-84
  • 3 Volkmann J, Wolters A, Kupsch A. et al; DBS study group for dystonia. Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial. Lancet Neurol 2012; 11 (12) 1029-10388
  • 4 Zhang K, Bhatia S, Oh MY, Cohen D, Angle C, Whiting D. Long-term results of thalamic deep brain stimulation for essential tremor. J Neurosurg 2010; 112 (06) 1271-1276
  • 5 Servello D, Sassi M, Gaeta M, Ricci C, Porta M. Tourette syndrome (TS) bears a higher rate of inflammatory complications at the implanted hardware in deep brain stimulation (DBS). Acta Neurochir (Wien) 2011; 153 (03) 629-632
  • 6 de Koning PP, Figee M, van den Munckhof P, Schuurman PR, Denys D. Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets. Curr Psychiatry Rep 2011; 13 (04) 274-282
  • 7 Paluzzi A, Bain PG, Liu X, Yianni J, Kumarendran K, Aziz TZ. Pregnancy in dystonic women with in situ deep brain stimulators. Mov Disord 2006; 21 (05) 695-698
  • 8 Lefaucheur R, Derrey S, Borden A, Verspyck E, Tourrel F, Maltête D. Patient with perinatal brain injury dystonia treated by deep brain stimulation: management during pregnancy. Rev Neurol (Paris) 2015; 171 (01) 90-91
  • 9 Scelzo E, Mehrkens JH, Bötzel K. et al. Deep brain stimulation during pregnancy and delivery: experience from a series of “DBS babies.”. Front Neurol 2015; 6: 191
  • 10 Ziman N, Coleman RR, Starr PA. et al. Pregnancy in a series of dystonia patients treated with deep brain stimulation: outcomes and management recommendation. Stereotact Funct Neurosurg 2016; 94 (01) 60-65
  • 11 Park HR, Lee JM, Park H. et al. Pregnancy and delivery in a generalized dystonia patient treated with internal globus pallidal deep brain stimulation: a case report. J Korean Med Sci 2017; 32 (01) 155-159
  • 12 Bóné B, Kovács N, Balás I, Horváth RA, Dóczi T, Janszky J. Pregnancy and deep brain stimulation therapy for epilepsy. Epileptic Disord 2021; 23 (04) 633-638
  • 13 House PM, Herzer A, Lorenzi I. et al. Deep brain stimulation (DBS) of anterior nucleus thalami (ANT) in female epilepsy patients during pregnancy and delivery: experience from two cases. Epileptic Disord 2021; 23 (06) 933-936
  • 14 Kestenbaum M, Robakis D, Ford B, Alcalay RN, Louis ED. Clinical characteristics of patients with Parkinson's disease and essential tremor undergoing deep brain stimulation surgery at Columbia university medical center, 2009–2016. Isr Med Assoc J 2016; 18 (07) 386-390
  • 15 Routiot T, Lurel S, Denis E, Barbarino-Monnier P. Parkinson's disease and pregnancy: case report and literature review. J Gynecol Obstet Biol Reprod (Paris) 2000; 29 (05) 454-457
  • 16 Hagell P, Odin P, Vinge E. Pregnancy in Parkinson's disease: a review of the literature and a case report. Mov Disord 1998; 13 (01) 34-38
  • 17 Dronacharya Lamichhane NS. Narayanan, Pedro Gonzalez-Alegre. Two cases of pregnancy in Parkinson's disease. Parkinsonism Relat Disord 2014; 20: 239-240
  • 18 Mucchiut M, Belgrado E, Cutuli D, Antonini A, Bergonzi P. Pramipexole-treated Parkinson's disease during pregnancy. Mov Disord 2004; 19 (09) 1114-1115
  • 19 Shulman LM, Minagar A, Weiner WJ. The effect of pregnancy in Parkinson's disease. Mov Disord 2000; 15 (01) 132-135
  • 20 Campos-Sousa RN, Almeida KJ, Dos Santos AR, Lopes-Costa PV, da Silva BB. Multiparity after an initial diagnosis of Parkinson's disease: a report on a rare case. Fertil Steril 2008; 90 (05) 2005.e1-2005.e2
  • 21 Zhu L, Cairns NJ, Tabbal SD, Racette BA. Pregnancy in multiple system atrophy: a case report. J Med Case Reports 2011; 5: 599
  • 22 Petrou I, Momjian S, Modaressi A. Submammary placement of neurostimulation device: broadening the spectrum of cosmetic techniques. Eur J Plast Surg 2021; 44: 143-146
  • 23 Bhatia S, Zhang K, Oh M, Angle C, Whiting D. Infections and hardware salvage after deep brain stimulation surgery: a single-center study and review of the literature. Stereotact Funct Neurosurg 2010; 88 (03) 147-155
  • 24 Garg A, Mohan AL, Garell PC. Placement of the internal pulse generator for deep brain stimulation in the upper bacl to prezent fracture of the extension wire due to generator rotation: case report. Parkinsons Dis 2010; 2010: 189371