Subscribe to RSS
DOI: 10.1055/s-0042-1755545
Pulmonary Aspergillosis Silently Presenting as Pneumothorax in Children with Leukemia: A Report of Three Cases.
Funding None.
Abstract
Aspergillosis causes invasive pulmonary disease in patients with hematological malignancies. Children with invasive pulmonary aspergillosis (IPA) usually have nonspecific radiographic findings unlike cavitary lesions commonly seen in adults. Pneumothorax due to rupture of peripheral fungal lesion may be a severe complication in patients with neutropenia. Here, we describe three children during induction chemotherapy for B-lymphoblastic leukemia with pneumothorax as a presenting feature of pulmonary aspergillosis.
Note
The manuscript has been read and approved by all the authors, and the requirements for authorship have been met, and each author believes that the manuscript represents honest work.
Declaration of Patient Consent
The authors certify that they have obtained all appropriate patient consent forms.
Publication History
Article published online:
20 October 2022
© 2022. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Groll AH, Pana D, Lanternier F. et al; 8th European Conference on Infections in Leukaemia. 8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation. Lancet Oncol 2021; 22 (06) e254-e269
- 2 Pappas PG, Alexander BD, Andes DR. et al. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis 2010; 50 (08) 1101-1111
- 3 Abbasi S, Shenep JL, Hughes WT, Flynn PM. Aspergillosis in children with cancer: A 34-year experience. Clin Infect Dis 1999; 29 (05) 1210-1219
- 4 Das N, Banavali S, Bakhshi S. et al. Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India. Trials 2022; 23 (01) 102
- 5 Pana ZD, Roilides E, Warris A, Groll AH, Zaoutis T. Epidemiology of invasive fungal disease in children. J Pediatric Infect Dis Soc 2017; 6 (suppl_1): S3-S11
- 6 Tragiannidis A, Kattamis A, Vyzantiadis TA. Invasive fungal infections in children with haematological malignancies: diagnostic and therapeutic challenges. J Fungi (Basel) 2021; 7 (07) 516
- 7 Donnelly JP, Chen SC, Kauffman CA. et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for research and Treatment of cancer and the Mycoses Study Group education and research consortium. Clin Infect Dis 2020; 71 (06) 1367-1376
- 8 Grigull L, Beier R, Schrauder A. et al. Invasive fungal infections are responsible for one-fifth of the infectious deaths in children with ALL. Mycoses 2003; 46 (11,12): 441-446
- 9 Denning DW, Marinus A, Cohen J. et al; EORTC Invasive Fungal Infections Cooperative Group. An EORTC multicentre prospective survey of invasive aspergillosis in haematological patients: diagnosis and therapeutic outcome. J Infect 1998; 37 (02) 173-180
- 10 Cornillet A, Camus C, Nimubona S. et al. Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis 2006; 43 (05) 577-584
- 11 Thomas KE, Owens CM, Veys PA, Novelli V, Costoli V. The radiological spectrum of invasive aspergillosis in children: a 10-year review. Pediatr Radiol 2003; 33 (07) 453-460
- 12 Burgos A, Zaoutis TE, Dvorak CC. et al. Pediatric invasive aspergillosis: a multicenter retrospective analysis of 139 contemporary cases. Pediatrics 2008; 121 (05) e1286-e1294
- 13 Ödev K, Çaliskan U, Emlik D, Koç H, Koç S. Pneumomediastinum and pneumopericardium due to intracavitary aspergilloma: an unusual complication of fungal pneumonia. Pediatr Radiol 2002; 32 (02) 143-145
- 14 Todeschini G, Murari C, Bonesi R. et al. Invasive aspergillosis in neutropenic patients: rapid neutrophil recovery is a risk factor for severe pulmonary complications. Eur J Clin Invest 1999; 29 (05) 453-457
- 15 Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ. Role of molecular biomarkers in the diagnosis of invasive fungal diseases in children. J Pediatric Infect Dis Soc 2017; 6 (suppl_1): S32-S44