Subscribe to RSS
A Novel Model of Perifascial Areolar Tissue Transplant in RatsFunding The authors disclose receipt of the following partial financial support for the research, authorship, and/or publication of this article: JSPS Kakenhi, grant number 18K09475.
Background Perifascial areolar tissue (PAT) transplant is a method of transplanting loose connective tissue harvested in a sheet form from above the fascia to the wound bed and is effective for wounds with exposed ischemic tissue. However, the engraftment mechanism is unknown, and no animal models of PAT transplant for wound healing exist.
Methods In this study, we harvested connective tissue from the backs of Wistar rats in a sheet form to simulate a human PAT transplant. The PAT was affixed to exposed bone of the head.
Results In the PAT(+) group, the wound areas gradually decreased due to epithelialization and contraction. The wound area of the PAT(+) group was significantly smaller than that of the PAT(−) group.
Conclusions This clinically relevant rat model is useful for elucidating the mechanism of the PAT transplant and establishing a reliable surgical method.
Research Ethics and Patient Consent
All the study procedures were performed in accordance with the guidelines of our institutional animal care and use committee (approval number 2019-401).
Article published online:
25 September 2022
© 2022. Association of Plastic Surgeons of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
- 1 Kouraba S, Sakamoto T, Kimura C. et al. Perifascial areolar tissue (PAT) graft. ANZ J Surg 2003; 73 (Suppl.): A260
- 2 Koga Y, Komuro Y, Yamato M. et al. Recovery course of full-thickness skin defects with exposed bone: an evaluation by a quantitative examination of new blood vessels. J Surg Res 2007; 137 (01) 30-37
- 3 Miyanaga T, Haseda Y, Daizo H. et al. A perifascial areolar tissue graft with topical administration of basic fibroblast growth factor for treatment of complex wounds with exposed tendons and/or bones. J Foot Ankle Surg 2018; 57 (01) 104-110
- 4 Koizumi T, Nakagawa M, Nagamatsu S, Kayano S, Akazawa S. Perifascial areolar tissue graft as a nonvascularized alternative to flaps. Plast Reconstr Surg 2010; 126 (04) 182e-183e
- 5 Koizumi T, Nakagawa M, Nagamatsu S. et al. The versatile perifascial areolar tissue graft: adaptability to a variety of defects. J Plast Surg Hand Surg 2013; 47 (04) 276-280
- 6 Hayashi A, Komoto M, Tanaka R. et al. The availability of perifascial areolar tissue graft for deep cutaneous ulcer coverage. J Plast Reconstr Aesthet Surg 2015; 68 (12) 1743-1749
- 7 Abe Y, Hashimoto I, Ishida S, Mineda K, Yoshimoto S. The perifascial areolar tissue and negative pressure wound therapy for one-stage skin grafting on exposed bone and tendon. J Med Invest. 2018; 65 (1.2) 96-102
- 8 Ito T, Akazawa S, Ichikawa Y. et al. Exposed artificial plate covered with perifascial areolar tissue as a nonvascularized graft. Plast Reconstr Surg Glob Open. 2019; 7 (02) e2109
- 9 Nakajima H, Imanishi N, Minabe T, Kishi K, Aiso S. Anatomical study of subcutaneous adipofascial tissue: a concept of the protective adipofascial system (PAFS) and lubricant adipofascial system (LAFS). Scand J Plast Reconstr Surg Hand Surg 2004; 38 (05) 261-266
- 10 van Wingerden JJ, Lapid O, van der Horst CM. Bridging phenomenon—simplifying complex ear reconstructions. Head Neck 2014; 36 (05) 735-738