Download PDF
Int J Angiol
DOI: 10.1055/s-0042-1756216
Case Report

Upper-Extremity Deep Venous Thrombosis after Whole Blood Donation—A Case Report

Oluseyi Abidoye
1   Internal Medicine Department, Northeast Georgia Medical Center, Gainesville, Georgia
,
Andrew Johnson
2   Longstreet Clinic Cancer Center, Gainesville, Georgia
,
Young Min Cho 
1   Internal Medicine Department, Northeast Georgia Medical Center, Gainesville, Georgia
,
Henry Ogbuagu
1   Internal Medicine Department, Northeast Georgia Medical Center, Gainesville, Georgia
,
Hasan Choudhury
1   Internal Medicine Department, Northeast Georgia Medical Center, Gainesville, Georgia
,
Ryosuke Takegawa
3   Feinstein Institutes for Medical Research, Manhasset, New York
4   Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York
,
Kei Hayashida
3   Feinstein Institutes for Medical Research, Manhasset, New York
4   Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York
,
Koichiro Shinozaki
3   Feinstein Institutes for Medical Research, Manhasset, New York
4   Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York
,
Tomoaki Aoki
3   Feinstein Institutes for Medical Research, Manhasset, New York
4   Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York
,
Yu Okuma
3   Feinstein Institutes for Medical Research, Manhasset, New York
5   Department of Neurological Surgery, Sonoda Daiichi Hospital, Tokyo, Japan
,
Stavros Zanos
3   Feinstein Institutes for Medical Research, Manhasset, New York
6   Elmezzi Graduate School of Molecular Medicine, Manhasset, New York
,
Stefanos Zafeiropoulos
3   Feinstein Institutes for Medical Research, Manhasset, New York
6   Elmezzi Graduate School of Molecular Medicine, Manhasset, New York
,
Dimitrios Giannis
7   Department of Surgery, North Shore University Hospital, Manhasset, New York
,
Derek O. Pipolo
7   Department of Surgery, North Shore University Hospital, Manhasset, New York
,
Lance B. Becker
3   Feinstein Institutes for Medical Research, Manhasset, New York
4   Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York
8   Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York
,
Santiago J. Miyara 
9   Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
,
Sara Guevara
8   Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York
10   Department of Family Medicine, Glen Cove Hospital, Glen Cove, New York
,
Ernesto P. Molmenti
7   Department of Surgery, North Shore University Hospital, Manhasset, New York
10   Department of Family Medicine, Glen Cove Hospital, Glen Cove, New York
› Author Affiliations
› Further Information
    Permissions and Reprints

Abstract

Upper-extremity deep venous thrombosis (UEDVT) after whole blood donation is rarely reported. Blood donation has a low rate of complications and is typically safe. A small percentage of blood donors experience donation-related events such as UEDVT, which are extremely rare. We are reporting a rare case of a UEDVT following blood donation. This is an extremely rare event; only five cases were reported to our knowledge. A 22-year-old Caucasian woman with a past medical history of provoked pulmonary embolism completed 6 months of apixaban and negative thrombophilia workup presented to the hospital with complaints of progressive pain and swelling in her right arm. The patient reports donating blood using her right arm in January 2021. Phlebotomy duration for blood donation was approximately 10minutes. She reported pain and swelling several days after blood donation. Subsequently, a duplex ultrasound showed a thrombus in the right brachial vein. The patient was started on apixaban for 6 months. Although most whole blood donors do not experience complications, DVT is a rare complication from whole blood donation with severe consequences. It should be considered in a donor with worsening pain and swelling.

Keyword

upper-extremity deep venous thrombosis - whole blood donation - phlebotomy - Virchow's triad - venous duplex - apixaban - warfarin


Publication History

Article published online:
13 September 2022

© 2022. International College of Angiology. This article is published by Thieme.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Newman BH. Donor reactions and injuries from whole blood donation. Transfus Med Rev 1997; 11 (01) 64-75
    CrossrefPubMedGoogle Scholar
  • 2 Newman B. Arm complications after manual whole blood donation and their impact. Transfus Med Rev 2013; 27 (01) 44-49
    CrossrefPubMedGoogle Scholar
  • 3 Covin RB, Rich NL, Aysola A. Upper-extremity deep venous thrombosis complicating whole-blood donation. Transfusion 2004; 44 (04) 586-590
    CrossrefPubMedGoogle Scholar
  • 4 Featherstone T, Bayliss AP. Deep venous thrombosis of the upper extremity–a case report. Angiology 1987; 38 (10) 793-796
    CrossrefPubMedGoogle Scholar
  • 5 Newman B, Rajpurkar M, Ozgonenel B, Lal A, Kuriakose P. Upper-extremity deep venous thrombosis after whole blood donation: report of three cases from a single blood center. Transfusion 2015; 55 (06) 1290-1293
    CrossrefPubMedGoogle Scholar
  • 6 Yazer MH, Vassallo R, Delaney M. et al; Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Trends in age and red blood cell donation habits among several racial/ethnic minority groups in the United States. Transfusion 2017; 57 (07) 1644-1655
    CrossrefPubMedGoogle Scholar
  • 7 Newman BH, Pichette S, Pichette D, Dzaka E. Adverse effects in blood donors after whole-blood donation: a study of 1000 blood donors interviewed 3 weeks after whole-blood donation. Transfusion 2003; 43 (05) 598-603
    CrossrefPubMedGoogle Scholar
  • 8 Popovsky MA, Whitaker B, Arnold NL. Severe outcomes of allogeneic and autologous blood donation: frequency and characterization. Transfusion 1995; 35 (09) 734-737
    CrossrefPubMedGoogle Scholar
  • 9 Kumar S, Agnihotri SK, Khanna SK. Brachial artery pseudoaneurysm following blood donation. Transfusion 1995; 35 (09) 791-791
    CrossrefPubMedGoogle Scholar
  • 10 Mustafa J, Asher I, Sthoeger Z. Upper extremity deep vein thrombosis: symptoms, diagnosis, and treatment. Isr Med Assoc J 2018; 20 (01) 53-57
    PubMedGoogle Scholar
  • 11 Cote LP, Greenberg S, Caprini JA. et al; RIETE Investigators. Comparisons between upper and lower extremity deep vein thrombosis: a review of the RIETE registry. Clin Appl Thromb Hemost 2017; 23 (07) 748-754
    CrossrefPubMedGoogle Scholar
  • 12 Khan O, Marmaro A, Cohen DA. A review of upper extremity deep vein thrombosis. Postgrad Med 2021; 133 (sup1): 3-10
    CrossrefPubMedGoogle Scholar
  • 13 Delluc A, Le Mao R, Tromeur C. et al. Incidence of upper-extremity deep vein thrombosis in western France: a community-based study. Haematologica 2019; 104 (01) e29-e31
    CrossrefPubMedGoogle Scholar
  • 14 Hughes SF, Hendricks BD, Edwards DR, Bastawrous SS, Roberts GE, Middleton JF. Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. J Inflamm (Lond) 2007; 4 (01) 1-8
    CrossrefPubMedGoogle Scholar
  • 15 Rasmussen K, Møller J, Lyngbak M. Within-person variation of plasma homocysteine and effects of posture and tourniquet application. Clin Chem 1999; 45 (10) 1850-1855
    CrossrefPubMedGoogle Scholar
  • 16 Prandoni P, Polistena P, Bernardi E. et al. Upper-extremity deep vein thrombosis. Risk factors, diagnosis, and complications. Arch Intern Med 1997; 157 (01) 57-62
    CrossrefPubMedGoogle Scholar
  • 17 Joffe HV, Kucher N, Tapson VF, Goldhaber SZ. Deep Vein Thrombosis (DVT) FREE Steering Committee. Upper-extremity deep vein thrombosis: a prospective registry of 592 patients. Circulation 2004; 110 (12) 1605-1611
    CrossrefPubMedGoogle Scholar