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CC BY 4.0 · Semin Thromb Hemost 2023; 49(03): 279-283
DOI: 10.1055/s-0042-1756705
Review Article

The Pathophysiological Role of Platelet-Derived Extracellular Vesicles

Meryem Mabrouk
1   Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco
2   Department of Biology, Faculty of Sciences, Immunology and Biodiversity Laboratory, Hassan II University, Casablanca, Morocco
,
Fadila Guessous
3   Research of Center, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco
,
Abdallah Naya
2   Department of Biology, Faculty of Sciences, Immunology and Biodiversity Laboratory, Hassan II University, Casablanca, Morocco
,
Yahye Merhi
4   Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Research Center, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada
,
Younes Zaid
1   Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco
2   Department of Biology, Faculty of Sciences, Immunology and Biodiversity Laboratory, Hassan II University, Casablanca, Morocco
› Author Affiliations Funding Y.Z. and M.M. are supported by Balvi Filantropic Fund (PR-BLV-20220527).
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Abstract

Platelets are very abundant in the blood, where they play a role in hemostasis, inflammation, and immunity. When activated, platelets undergo a conformational change that allows the release of numerous effector molecules as well as the production of extracellular vesicles, which are circulating submicron vesicles (10 to 1,000 nm in diameter) released into the extracellular space. Extracellular vesicles are formed by the budding of platelet and they carry some of its contents, including nucleic acids, surface proteins, and organelles. While platelets cannot cross tissue barriers, platelet-derived extracellular vesicles can enter the lymph, bone marrow, and synovial fluid. This allows the transfer of diverse contents carried by these platelet-derived vesicles to cell recipients and organs inaccessible to platelets where they can perform many functions. This review highlights the importance of these platelet-derived extracellular vesicles under different physiological and pathophysiological conditions.

Keywords

extracellular vesicles - platelets - coagulation - platelet-derived extracellular vesicles

Authors' Contributions

M.M., F.G., A.N., and Y.Z. contributed to literature search and writing of this review. Y.M. and Y.Z. designed the structure and content of this review. Y.Z. provided the figure. All authors approved the submitted version of the manuscript.




Publication History

Article published online:
29 September 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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