PDF herunterladen
CC BY-NC-ND 4.0 · South Asian J Cancer 2023; 12(03): 256-262
DOI: 10.1055/s-0042-1758682
Original Article
Head and Neck Cancer

Treatment Outcomes of Adenoid Cystic Carcinomas of the Head and Neck Region—A Single-Institution Experience

Malu Rafi
1   Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
,
Rejnish Kumar
1   Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
,
Kainickal Cessal Thomas
1   Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
,
Nebu Abraham George 
2   Department of Surgical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
,
Preethi Sara George 
3   Department of Cancer Epidemiology and Biostatistics, Regional Cancer Centre, Trivandrum, Kerala, India
,
Kunnambath Ramadas
1   Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
› Institutsangaben
Funding None.
› Weitere Informationen
Auch verfügbar auf
  Lizenzen und Reprints

Abstract

Zoom Image
Malu Rafi

Objectives This study was undertaken to evaluate the characteristics and treatment outcomes of patients with adenoid cystic carcinomas of the head and neck region treated at a tertiary cancer center in south India.

Materials and Methods This was a retrospective study done on patients treated at the institute between 2004 and 2011. Clinicopathological details and treatment outcomes were captured from the treatment records to estimate the treatment outcomes and factors affecting them.

Results There were a total of 140 patients with mean age of presentation of 46 years and a median follow-up of 65 months. The most common single site of presentation was the oral cavity. One-hundred eighteen patients (84.3%) underwent primary surgical resection in which 38% had negative surgical margins. Ninety-nine patients were given adjuvant radiotherapy and 18 patients received radical radiotherapy, mostly for surgically inaccessible and inoperable tumors.

Median time to recurrence and distant metastasis was 37 and 34 months, respectively. The overall survival and disease-free survival estimate using the Kaplan–Meier method were 92.3 and 71.9%, respectively, at 5 years. Surgical removal of the primary tumor and the nodal stage had the most significant impact on the overall survival outcomes of these patients.

Conclusion Surgery remains the most impactful treatment modality in the management of these rare epithelial tumors. The use of adjuvant radiotherapy may help to tackle the issues of perineural spread and inadequate surgical margins in technically difficult sites. Radical radiotherapy also has impressive response rates.

Keywords

Adenoid Cystic Carcinoma of head and neck region - treatment outcomes - role of surgery - adjuvant radiotherapy - radical radiotherapy - factors affecting outcomes


Publikationsverlauf

Artikel online veröffentlicht:
31. Dezember 2022

© 2022. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 

  • References

  • 1 Billroth T. Observations on tumors of the salivary glands. Arch Path Anat 1859; 17: 357-375
    Suche in Google Scholar
  • 2 Jones AS, Beasley NJ, Houghton DJ, Helliwell TR, Husband DJ. Tumours of the minor salivary glands. Clin Otolaryngol Allied Sci 1998; 23 (01) 27-33
    CrossrefPubMedSuche in Google Scholar
  • 3 Sultan I, Rodriguez-Galindo C, Al-Sharabati S, Guzzo M, Casanova M, Ferrari A. Salivary gland carcinomas in children and adolescents: a population-based study, with comparison to adult cases. Head Neck 2011; 33 (10) 1476-1481
    CrossrefPubMedSuche in Google Scholar
  • 4 Larson DL, Rodin AE, Roberts DK, O'Steen WK, Rapperport AS, Lewis SR. Perineural lymphatics: myth or fact. Am J Surg 1966; 112 (04) 488-492
    CrossrefPubMedSuche in Google Scholar
  • 5 Ciccolallo L, Licitra L, Cantú G, Gatta G. EUROCARE Working Group. Survival from salivary glands adenoid cystic carcinoma in European populations. Oral Oncol 2009; 45 (08) 669-674
    CrossrefPubMedSuche in Google Scholar
  • 6 da Cruz Perez DE, de Abreu Alves F, Nishimoto IN, de Almeida OP, Kowalski LP. Prognostic factors in head and neck adenoid cystic carcinoma. Oral Oncol 2006; 42: 139-146
    CrossrefPubMedSuche in Google Scholar
  • 7 Agarwal JP, Jain S, Gupta T. et al. Intraoral adenoid cystic carcinoma: prognostic factors and outcome. Oral Oncol 2008; 44 (10) 986-993
    CrossrefPubMedSuche in Google Scholar
  • 8 Matsuba HM, Simpson JR, Mauney M, Thawley SE. Adenoid cystic salivary gland carcinoma: a clinicopathologic correlation. Head Neck Surg 1986; 8 (03) 200-204
    CrossrefPubMedSuche in Google Scholar
  • 9 Gomez DR, Hoppe BS, Wolden SL. et al. Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. Int J Radiat Oncol Biol Phys 2008; 70 (05) 1365-1372
    CrossrefPubMedSuche in Google Scholar
  • 10 Chen AM, Bucci MK, Weinberg V. et al. Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: prognostic features of recurrence. Int J Radiat Oncol Biol Phys 2006; 66 (01) 152-159
    CrossrefPubMedSuche in Google Scholar
  • 11 Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB. Radiotherapy alone or combined with surgery for salivary gland carcinoma. Cancer 2005; 103 (12) 2544-2550
    CrossrefPubMedSuche in Google Scholar
  • 12 Parsons JT, Mendenhall WM, Stringer SP, Cassisi NJ, Million RR. Management of minor salivary gland carcinomas. Int J Radiat Oncol Biol Phys 1996; 35 (03) 443-454
    CrossrefPubMedSuche in Google Scholar
  • 13 Chen AM, Bucci MK, Quivey JM, Garcia J, Eisele DW, Fu KK. Long-term outcome of patients treated by radiation therapy alone for salivary gland carcinomas. Int J Radiat Oncol Biol Phys 2006; 66 (04) 1044-1050
    CrossrefPubMedSuche in Google Scholar
  • 14 Rapidis AD, Givalos N, Gakiopoulou H. et al. Adenoid cystic carcinoma of the head and neck. Clinicopathological analysis of 23 patients and review of the literature. Oral Oncol 2005; 41 (03) 328-335
    CrossrefPubMedSuche in Google Scholar
  • 15 Kokemueller H, Eckardt A, Brachvogel P, Hausamen JE. Adenoid cystic carcinoma of the head and neck–a 20 years experience. Int J Oral Maxillofac Surg 2004; 33 (01) 25-31
    CrossrefPubMedSuche in Google Scholar