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CC BY 4.0 · Eur J Dent 2023; 17(04): 1000-1011
DOI: 10.1055/s-0042-1758788
Review Article

Highlights on Drug and Ion Release and Recharge Capacity of Antimicrobial Removable Prostheses

Reem Abualsaud 
1   Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
,
Mohammed M. Gad 
1   Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
› Author Affiliations
Funding This review article received no grant from any funding agency in the public, commercial, or not-for-profit sectors.
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Abstract

This article aimed to review the ion and drug release, recharge abilities, and antimicrobial properties of drug/ion-releasing removable prostheses, and to assess their capability in preventing and inhibiting denture stomatitis as well preventing caries and reversing carious lesions. Data was collected from published scientific papers listed in PubMed database from January 1975 to December 2021. English full-text articles, involving clinical or in vitro studies, focusing on removable prostheses and are concerned with drug/ion release and rechargeability as a way to prevent or inhibit denture stomatitis or dental caries were included. The relevant articles reported that ion- or drug-modified polymethylmethacrylate acts as a reservoir for these ions and drugs and is capable of releasing significant amounts with sustained release effect. Recharging of modified resin resulted in greater sustainability of ion and drug release, thus improving the long-term effects of protection against demineralization and reducing the adhesion of Streptococcus mutans and Candida albicans. Modifications of removable prostheses with rechargeable ions and drugs enhance remineralization, hinder demineralization, and reduce microbial adhesion in difficult-to-access areas. Selection of denture base for clinical use will consider its ability to act as an ion/drug reservoir that is capable of release and recharge.

Keywords

removable dental prostheses - PMMA - candidiasis - mineralization - recharge - dental caries - fluoride release - caries prevention - antimicrobial effect - denture stomatitis


Publication History

Article published online:
27 December 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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  • References

  • 1 Friel T, Waia S. Removable partial dentures for older adults. Prim Dent J 2020; 9 (03) 34-39
    CrossrefPubMedSearch in Google Scholar
  • 2 Gad MM, Fouda SM. Current perspectives and the future of Candida albicans-associated denture stomatitis treatment. Dent Med Probl 2020; 57 (01) 95-102
    CrossrefPubMedSearch in Google Scholar
  • 3 Al-Bakri IA, Harty D, Al-Omari WM, Swain MV, Chrzanowski W, Ellakwa A. Surface characteristics and microbial adherence ability of modified polymethylmethacrylate by fluoridated glass fillers. Aust Dent J 2014; 59 (04) 482-489
    CrossrefPubMedSearch in Google Scholar
  • 4 Clemons KV, Stevens DA. Efficacy of ravuconazole in treatment of mucosal candidosis in SCID mice. Antimicrob Agents Chemother 2001; 45 (12) 3433-3436
    CrossrefPubMedSearch in Google Scholar
  • 5 Kamijo K, Mukai Y, Tominaga T. et al. Fluoride release and recharge characteristics of denture base resins containing surface pre-reacted glass-ionomer filler. Dent Mater J 2009; 28 (02) 227-233
    CrossrefPubMedSearch in Google Scholar
  • 6 Margolis HC, Moreno EC, Murphy BJ. Effect of low levels of fluoride in solution on enamel demineralization in vitro. J Dent Res 1986; 65 (01) 23-29
    CrossrefPubMedSearch in Google Scholar
  • 7 Raszewski Z, Nowakowska D, Wieckiewicz W, Nowakowska-Toporowska A. Release and recharge of fluoride ions from acrylic resin modified with bioactive glass. Polymers (Basel) 2021; 13 (07) 1054
    CrossrefPubMedSearch in Google Scholar
  • 8 Nakornchai N, Arksornnukit M, Kamonkhantikul K, Takahashi H. The pH effect of solvent in silanization on fluoride released and mechanical properties of heat-cured acrylic resin containing fluoride-releasing filler. Dent Mater J 2016; 35 (03) 440-446
    CrossrefPubMedSearch in Google Scholar
  • 9 Han L, Cv E, Li M. et al. Effect of fluoride mouth rinse on fluoride releasing and recharging from aesthetic dental materials. Dent Mater J 2002; 21 (04) 285-295
    CrossrefPubMedSearch in Google Scholar
  • 10 Mukai Y, Kamijo K, Fujino F, Hirata Y, Teranaka T, ten Cate JM. Effect of denture base-resin with prereacted glass-ionomer filler on dentin demineralization. Eur J Oral Sci 2009; 117 (06) 750-754
    CrossrefPubMedSearch in Google Scholar
  • 11 Al-Bakri IA, Swain MV, Naoum SJ, Al-Omari WM, Martin E, Ellakwa A. Fluoride release, recharge and flexural properties of polymethylmethacrylate containing fluoridated glass fillers. Aust Dent J 2014; 59 (02) 208-214
    CrossrefPubMedSearch in Google Scholar
  • 12 Salerno C, Pascale M, Contaldo M. et al. Candida-associated denture stomatitis. Med Oral Patol Oral Cir Bucal 2011; 16 (02) e139-e143
    CrossrefPubMedSearch in Google Scholar
  • 13 Tamura M, Cueno ME, Abe K, Kamio N, Ochiai K, Imai K. Ions released from a S-PRG filler induces oxidative stress in Candida albicans inhibiting its growth and pathogenicity. Cell Stress Chaperones 2018; 23 (06) 1337-1343
    CrossrefPubMedSearch in Google Scholar
  • 14 Lee JH, El-Fiqi A, Jo JK. et al. Development of long-term antimicrobial poly(methyl methacrylate) by incorporating mesoporous silica nanocarriers. Dent Mater 2016; 32 (12) 1564-1574
    CrossrefPubMedSearch in Google Scholar
  • 15 ten Cate JM, Damen JJM, Buijs MJ. Inhibition of dentin demineralization by fluoride in vitro. Caries Res 1998; 32 (02) 141-147
    CrossrefPubMedSearch in Google Scholar
  • 16 Buzalaf MAR, Pessan JP, Honório HM, Ten Cate JM. Mechanisms of action of fluoride for caries control. Monogr Oral Sci 2011; 22: 97-114
    CrossrefPubMedSearch in Google Scholar
  • 17 Koo H. Strategies to enhance the biological effects of fluoride on dental biofilms. Adv Dent Res 2008; 20 (01) 17-21
    CrossrefPubMedSearch in Google Scholar
  • 18 Kiatsirirote K, Sitthisettapong T, Phantumvanit P, Chan DCN. Fluoride-releasing effect of a modified resin denture containing S-PRG fillers on salivary fluoride retention: a randomized clinical study. Caries Res 2019; 53 (02) 137-144
    CrossrefPubMedSearch in Google Scholar
  • 19 Fujimoto Y, Iwasa M, Murayama R, Miyazaki M, Nagafuji A, Nakatsuka T. Detection of ions released from S-PRG fillers and their modulation effect. Dent Mater J 2010; 29 (04) 392-397
    CrossrefPubMedSearch in Google Scholar
  • 20 Basso GR, Della Bona A, Gobbi DL, Cecchetti D. Fluoride release from restorative materials. Braz Dent J 2011; 22 (05) 355-358
    CrossrefPubMedSearch in Google Scholar
  • 21 Gad MM, Abualsaud R, Khan SQ. Hydrophobicity of denture base resins: a systematic review and meta-analysis. J Int Soc Prev Community Dent 2022; 12 (02) 139-159
    CrossrefPubMedSearch in Google Scholar
  • 22 Elboraey AN, Abo-Almaged HH, El-Ashmawy AAE. et al. Biological and mechanical properties of denture base material as a vehicle for novel hydroxyapatite nanoparticles loaded with drug. Adv Pharm Bull 2021; 11 (01) 86-95
    CrossrefPubMedSearch in Google Scholar
  • 23 Tsutsumi C, Takakuda K, Wakabayashi N. Reduction of Candida biofilm adhesion by incorporation of prereacted glass ionomer filler in denture base resin. J Dent 2016; 44: 37-43
    CrossrefPubMedSearch in Google Scholar
  • 24 Kiesow A, Sarembe S, Pizzey RL, Axe AS, Bradshaw DJ. Material compatibility and antimicrobial activity of consumer products commonly used to clean dentures. J Prosthet Dent 2016; 115 (02) 189-198.e8
    CrossrefPubMedSearch in Google Scholar
  • 25 Webb BC, Thomas CJ, Willcox MD, Harty DW, Knox KW. Candida-associated denture stomatitis. Aetiology and management: a review. Part 1. Factors influencing distribution of Candida species in the oral cavity. Aust Dent J 1998; 43 (01) 45-50
    CrossrefPubMedSearch in Google Scholar
  • 26 Pavarina AC, Pizzolitto AC, Machado AL, Vergani CE, Giampaolo ET. An infection control protocol: effectiveness of immersion solutions to reduce the microbial growth on dental prostheses. J Oral Rehabil 2003; 30 (05) 532-536
    CrossrefPubMedSearch in Google Scholar
  • 27 Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence 2013; 4 (02) 119-128
    CrossrefPubMedSearch in Google Scholar
  • 28 Mayahara M, Kataoka R, Arimoto T. et al. Effects of surface roughness and dimorphism on the adhesion of Candida albicans to the surface of resins: scanning electron microscope analyses of mode and number of adhesions. J Investig Clin Dent 2014; 5 (04) 307-312
    CrossrefPubMedSearch in Google Scholar
  • 29 Whiteway M, Bachewich C. Morphogenesis in Candida albicans. Annu Rev Microbiol 2007; 61: 529-553
    CrossrefPubMedSearch in Google Scholar
  • 30 Takakusaki K, Fueki K, Tsutsumi C. et al. Effect of incorporation of surface pre-reacted glass ionomer filler in tissue conditioner on the inhibition of Candida albicans adhesion. Dent Mater J 2018; 37 (03) 453-459
    CrossrefPubMedSearch in Google Scholar
  • 31 Jackson S, Coulthwaite L, Loewy Z, Scallan A, Verran J. Biofilm development by blastospores and hyphae of Candida albicans on abraded denture acrylic resin surfaces. J Prosthet Dent 2014; 112 (04) 988-993
    CrossrefPubMedSearch in Google Scholar
  • 32 Ueno Y, Fukumatsu M, Ogasawara A, Watanabe T, Mikami T, Matsumoto T. Hyphae formation of Candida albicans is regulated by polyamines. Biol Pharm Bull 2004; 27 (06) 890-892
    CrossrefPubMedSearch in Google Scholar
  • 33 Flisfisch S, Meyer J, Meurman JH, Waltimo T. Effects of fluorides on Candida albicans. Oral Dis 2008; 14 (04) 296-301
    CrossrefPubMedSearch in Google Scholar
  • 34 Bergman B, Hugoson A, Olsson CO. Caries and periodontal status in patients fitted with removable partial dentures. J Clin Periodontol 1977; 4 (02) 134-146
    CrossrefPubMedSearch in Google Scholar
  • 35 Naoum S, Ellakwa A, Martin F, Swain M. Fluoride release, recharge and mechanical property stability of various fluoride-containing resin composites. Oper Dent 2011; 36 (04) 422-432
    CrossrefPubMedSearch in Google Scholar
  • 36 Harhash AY, ElSayad II, Zaghloul AGS. A comparative in vitro study on fluoride release and water sorption of different flowable esthetic restorative materials. Eur J Dent 2017; 11 (02) 174-179
    Thieme ConnectPubMedSearch in Google Scholar
  • 37 Meurman JH, Kari K, Waltimo T, Kotiranta A, Inkeri J, Samaranayake LP. In vitro antifungal effect of amine fluoride-stannous fluoride combination on oral Candida species. Oral Dis 2006; 12 (01) 45-50
    CrossrefPubMedSearch in Google Scholar
  • 38 Yamauchi M, Nigauri A, Yamamoto K, Nakazato G, Kawano J, Kimura K. Antibacterial actions of denture base resin on oral bacteria [in Japanese]. Nippon Hotetsu Shika Gakkai Zasshi 1989; 33 (03) 571-576
    CrossrefPubMedSearch in Google Scholar
  • 39 Sun X, Cao Z, Yeh CK, Sun Y. Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials. Colloids Surf B Biointerfaces 2013; 110 (110) 96-104
    CrossrefPubMedSearch in Google Scholar
  • 40 Malakhov A, Wen J, Zhang BX. et al. Rechargeable anticandidal denture material with sustained release in saliva. Oral Dis 2016; 22 (05) 391-398
    CrossrefPubMedSearch in Google Scholar
  • 41 Lin DM, Kalachandra S, Valiyaparambil J, Offenbacher S. A polymeric device for delivery of anti-microbial and anti-fungal drugs in the oral environment: effect of temperature and medium on the rate of drug release. Dent Mater 2003; 19 (07) 589-596
    CrossrefPubMedSearch in Google Scholar
  • 42 Jo JK, El-Fiqi A, Lee JH, Kim DA, Kim HW, Lee HH. Rechargeable microbial anti-adhesive polymethyl methacrylate incorporating silver sulfadiazine-loaded mesoporous silica nanocarriers. Dent Mater 2017; 33 (10) e361-e372
    CrossrefPubMedSearch in Google Scholar
  • 43 Mohamed Hamouda I. Current perspectives of nanoparticles in medical and dental biomaterials. J Biomed Res 2012; 26 (03) 143-151
    CrossrefPubMedSearch in Google Scholar
  • 44 Gad MM, Fouda SM, Al-Harbi FA, Näpänkangas R, Raustia A. PMMA denture base material enhancement: a review of fiber, filler, and nanofiller addition. Int J Nanomedicine 2017; 12: 3801-3812
    CrossrefPubMedSearch in Google Scholar
  • 45 Amin WM, Al-Ali MH, Salim NA, Al-Tarawneh SK. A new form of intraoral delivery of antifungal drugs for the treatment of denture-induced oral candidosis. Eur J Dent 2009; 3 (04) 257-266
    Thieme ConnectPubMedSearch in Google Scholar
  • 46 Itota T, Carrick TE, Yoshiyama M, McCabe JF. Fluoride release and recharge in giomer, compomer and resin composite. Dent Mater 2004; 20 (09) 789-795
    CrossrefPubMedSearch in Google Scholar
  • 47 Bayrak S, Tunc ES, Aksoy A, Ertas E, Guvenc D, Ozer S. Fluoride release and recharge from different materials used as fissure sealants. Eur J Dent 2010; 4 (03) 245-250
    Thieme ConnectPubMedSearch in Google Scholar
  • 48 Zitz A, Gedalia I, Grajower R. Addition of fluoride compounds to acrylic resin plates: bending strength and fluoride release. J Oral Rehabil 1981; 8 (01) 37-41
    CrossrefPubMedSearch in Google Scholar
  • 49 Panácek A, Kolár M, Vecerová R. et al. Antifungal activity of silver nanoparticles against Candida spp. Biomaterials 2009; 30 (31) 6333-6340
    CrossrefPubMedSearch in Google Scholar
  • 50 Maluf CV, Peroni LV, Menezes LR, Coutinho W, Lourenço EJV, Telles DM. Evaluation of the physical and antifungal effects of chlorhexidine diacetate incorporated into polymethyl methacrylate. J Appl Oral Sci 2020; 28: e20190039
    CrossrefPubMedSearch in Google Scholar
  • 51 Xu X, Burgess JO. Compressive strength, fluoride release and recharge of fluoride-releasing materials. Biomaterials 2003; 24 (14) 2451-2461
    CrossrefPubMedSearch in Google Scholar
  • 52 Sjögren K. Toothpaste technique. Studies on fluoride delivery and caries prevention. Swed Dent J Suppl 1995; 110: 1-44
    PubMedSearch in Google Scholar
  • 53 Zhang JF, Wu R, Fan Y. et al. Antibacterial dental composites with chlorhexidine and mesoporous silica. J Dent Res 2014; 93 (12) 1283-1289
    CrossrefPubMedSearch in Google Scholar
  • 54 Shao W, Liu H, Liu X. et al. Development of silver sulfadiazine loaded bacterial cellulose/sodium alginate composite films with enhanced antibacterial property. Carbohydr Polym 2015; 132 (05) 351-358
    CrossrefPubMedSearch in Google Scholar
  • 55 Nakagawa M, Matsuya S, Udoh K. Effects of fluoride and dissolved oxygen concentrations on the corrosion behavior of pure titanium and titanium alloys. Dent Mater J 2002; 21 (02) 83-92
    CrossrefPubMedSearch in Google Scholar
  • 56 Watanabe I, Watanabe E. Surface changes induced by fluoride prophylactic agents on titanium-based orthodontic wires. Am J Orthod Dentofacial Orthop 2003; 123 (06) 653-656
    CrossrefPubMedSearch in Google Scholar
  • 57 Anusavice KJ, Zhang NZ, Shen C. Effect of CaF2 content on rate of fluoride release from filled resins. J Dent Res 2005; 84 (05) 440-444
    CrossrefPubMedSearch in Google Scholar
  • 58 Benton JB, Zimmerman BF, Zimmerman KL, Rawls HR. In vivo biocompatibility of an acrylic, fluoride-releasing, anion-exchange resin. J Appl Biomater 1993; 4 (01) 97-101
    CrossrefPubMedSearch in Google Scholar